Publications of 2019

Absolute and Relative Changes in Ultra-processed Food Consumption and Dietary Antioxidants in Severely Obese Adults 3 Months After Roux-en-Y Gastric Bypass

Sônia Lopes Pinto, Danielle Cristina Guimarães da Silva, Josefina Bressan
Obesity Surgery, v.29, p. 756-766
Impact factor: 3.947

Abstract: Introduction Patients that undergo Roux-en-Y gastric bypass (RYGB) experience a dramatic change in food consumption; however, it is unknown whether food consumption changes in relation to the level of food processing. Objective The aim of this work was to evaluate the relationship between ultra-processed food intake, dietary antioxidant capacity, and cardiometabolic risk factors in patients who underwent RYGB. Methods This study included 58 obese patients who underwent RYGB bariatric surgery. Data collection was done pre-operatively and at 3 months post-surgery. The foods consumed were documented using a 3-day 24-h dietary recall, and food intake was classified based on NOVA and dietary total antioxidant capacity (TAC). Anthropometric and biochemical data as well as information on body composition were also collected. Metabolic syndrome (MS) was classified in accordance with the International Diabetes Federation. Results Ultra-processed foods amounted to 27.2% and 19.7% of the total calories consumed during pre- and post-surgery periods, respectively. Regarding post-surgery, the caloric contribution of unprocessed or minimally processed foods increased, from 55.7 to 70.2% (p = 0.000). The TAC of foods consumed is inversely proportional to that of ultra-processed foods. Obvious changes were observed in all the anthropometric variables, lipid profile, glycemia, insulin resistance, and MS. Conclusion Our results indicate that bariatric surgery is able to promote improvement in the diet quality of patients, reducing the consumption of ultra-processed foods and increasing the intake of unprocessed foods. The TAC of foods consumed is inversely proportional to that of ultra-processed ones.

Abundance of Gut Microbiota, Concentration of Short-Chain Fatty Acids, and Inflammatory Markers Associated with Elevated Body Fat, Overweight, and Obesity in Female Adolescents

Valter Paulo Neves Miranda , Paulo Roberto dos Santos Amorim, Ronaldo Rocha Bastos
Eliane Rodrigues de Faria, Maria Eliza de Castro Moreira, Sylvia do Carmo Castro Franceschini, Maria do Carmo Gouveia Peluzio, Célia Lucia de Luces Fortes Ferreira, Silvia Eloiza Priore
Mediators of Inflammation, 2019, p. 1-11
Impact factor: 3.545

Abstract: Background and Aims. Overweight is ever more prevalent in the pediatric population, and this cardiometabolic factor can be associated with inflammatory markers, gut microbiota composition, and short-chain fatty acid (SCFA) concentrations. The aim of this study is to evaluate to what extent the abundance of gut microbiota phyla, SCFA concentrations, and inflammatory markers are associated with elevated body fat percentage (BF%), overweight, and obesity in female adolescents. Methods. An experimental and comparative study was conducted with 96 girls 14 to 19 years old. They were divided into 3 groups: G1—eutrophic (EUT) and adequate BF%; G2—EUT and high BF%; and G3—overweight (OW) or obese (OB) and high BF%. Waist circumference (WC), waist to height ratio (WtHR), and neck circumference (NC) were analyzed as indicators of central visceral adiposity. The BF% was evaluated by DEXA equipment. A food frequency questionnaire was used to evaluate the main types of food consumed in a week. The abundance of the Firmicutes, Bacteroidetes, and Proteobacteria phyla was measured by real-time polymerase chain reaction (RT-qPCR), and the SFCA concentrations (acetic, butyric, and propionic) were determined by high-performance liquid chromatography (HPLC). The inflammatory markers leptin, tumor necrosis factor-alpha, interleukin-6, and high-sensitivity C-reactive protein (hs-CRP) were assessed. Results. Female adolescents in groups G2 and G3 had greater central visceral adiposity and leptin concentration than those in group G1. No association was found between gut microbiota phyla abundance and SFCA concentrations in any of the groups. WC and frequency of consumption of oily and fatty foods were associated with Firmicutes abundance and SFCA concentrations. Girls with high WC also had the greatest leptin (p < 0:001) and hs-CRP (p = 0:035) concentrations. Conclusions. Inflammatory markers showed association with increased BMI and high BF% in female adolescents. The abundance of Firmicutes was associated with WC and NC, but not with BMI classification or BF%. Specifically, WC and the consumption of oils and fats showed correlation with SCFA concentrations. Different anthropometric indicators, such as NC and WC, should be incorporated into the clinical evaluation of the nutritional status of individuals in the adolescent population.

Acute treatment with Mangifera indica L. leaf extract attenuates liver inflammation in rats fed a cafeteria diet.

Renata Celi Lopes Toledo, Larissa Froede Brito, Mônica Maria Magalhães Caetano, Vânia Mayumi Nakajima, Bárbara Pereira da Silva, Filippe Elias de Freitas Soares, Hércia Stampini Duarte Martinoa and José Humberto de Queiroz
Food e Function, v. 10, n.8 p. 4861-4867
Impact factor: 3.947

Abstract: This study investigates the acute anti-inflammatory activity of Mangifera indica L. leaf extract and mangiferin in the liver of rats fed a cafeteria diet. This study was a randomized longitudinal experimental study. The animals were divided into three groups – Control: cafeteria diet (CD); Extract: CD + leaf extract (250 mg kg−1); and Mangiferin: CD + mangiferin (40 mg kg−1). Body weight and food intake were measured every week. On day eight, mRNA and protein expression of inflammatory markers were evaluated in the liver. Also, liver weight, SOD activity and malondialdehyde concentration were measured. Treatment for only eight days with mango leaf extract and mangiferin increased SOD activity. Mangiferin intake increased the mRNA expression of PPAR-α and HSP72. The leaf extract treatment enhanced PPAR-α mRNA expression. Mangiferin and leaf extract consumption caused a lower concentration of NFκB (p65) in nuclear extracts, and greater IL-10 mRNA and protein levels. This study highlights the potential of acute treatment with mango leaf extract and mangiferin to prevent liver inflammation caused by fat-rich diets. These results indicate a new use for a product that has low cost, is found in great amounts, and is not routinely used.

Agreement of body adiposity index (BAI) and paediatric body adiposity index (baip) in determining body fat in brazilian children and adolescents

Mariana de Santis Filgueiras, Roberta Stofeles Cecon, Eliane Rodrigues de Faria, Franciane Rocha de Faria, Patrícia Feliciano Pereira, Andreia Queiroz Ribeiro, Silvia Eloisa Priore
Public Health Nutrition, v 22, p 132-139
Impact factor: 2.326

Abstract: Objective: To evaluate agreement of the body adiposity index (BAI) and paediatric body adiposity index (BAIp) in estimating body fat compared with dual-energy X-ray absorptiometry (DXA) and to propose cut-off points for these indices to classify excess adiposity in Brazilian children and adolescents. Design: Cross-sectional study. Measures of weight, height, hip circumference, BMI and body fat percentage (%BF) assessed by DXA were taken, and BAI and BAIp were calculated. The Bland–Altman plot was used to estimate agreement between the methods, and the receiver-operating characteristic curve to determine the cut-off points for BAI and BAIp per age and sex in comparison with DXA. Setting: Viçosa, Minas Gerais, Brazil. Subjects: Children and adolescents aged 8–19 years (n 1049). Results: Of the children and adolescents, 52·4 % were girls. BAI and BAIp had satisfactory performance by the receiver-operating characteristic curve, except for the 18–19 years age group, whose BAIp had better predictive capacity than BAI. The agreement analysis showed that BAI overestimated %BF by 2·64 %, on average, using DXA; while BAIp underestimated %BF by 3·37 %. Conclusions: BAI and BAIp showed low agreement with the body fat obtained by obesity requiring caution when interpreting body composition data in children and adolescents.

Answer to the letter “TyG in insulin resistance prediction”

Sarah aparecida Vieira Ribeiro, Poliana Cristina de Almeida Fonseca, Cristiana Santos Andreoli, Andreia Queiroz Ribeiro, Helen Hermana Miranda Hermsdorff, Patricia Feliciano Pereira, Silvia Eloiza Priore, Sylvia do Carmo Castro Franceschini
Jornal de Pediatria, v. 2019, p.1-2

No abstract

Antiobesity effects of anthocyanins on mitochondrial biogenesis, inflammation and oxidative stress: a systematic review

Jaqueline Vieira Piovezana Gomes, Thaís Caroline Buttow Rigolon, Mariane Sampaio da Silveira Souza, Jacqueline Isaura Alvarez-Leite, Ceres Mattos Della Lucia, Hércia Stampini Duarte Martino, Carla de Oliveira Barbosa Rosa
Nutrition, v.66, p.192-202
Impact factor: 1.703

Abstract: Studies have shown that anthocyanins attenuate obesity. In this review, we confirm these effects and explain the possible mechanisms underlying them. A systematic search was conducted in electronic databases using obesity as the main term along with anthocyanins and the main anthocyanidins, including articles in Portuguese, English, and Spanish without any restriction as to year. The review was carried out by peers following PRISMA recommendations: 1980 studies were identified, and 19 articles were analyzed. The studies varied in relation to time, pathways, cells used, and anthocyanin types. The positive effects were observed in 50 adenosine monophosphate-activated protein kinase pathways and mitochondrial biogenesis and in a reduction in inflammation and oxidative stress. Anthocyanins can improve the metabolic control involved in obesity by reducing lipogenesis, oxidative stress, and inflammation. This can boost the speed of lipolysis and thermogenesis, regulate satiety, and reduce body fat accumulation. In addition, anthocyanins have shown promising effects on controlling obesity compared with the standard of care

Association of Dietary Patterns with Excess Weight and Body Adiposity in Brazilian Children: The Pase-Brasil Study

Naruna Pereira Rocha, Luana Cupertino Milagres, Mariana de santis Filgueiras, Lara Gomes Suhett, Mariane Alves Silva, Fernanda Martins Albuquerque, Andréia Queiroz Ribeiro, Sarah Aparecida Vieira, Juliana Farias de Novaes
Arquivo Brasileiro de Cardiologia, v. 113, p. 52-59
Impact factor: 1.679

Abstract: Background: Obesity is a multifactorial disease and a serious public health problem. Some of the associated factors are modifiable and, among them, the diet is highlighted. Objective: To evaluate the association of dietary patterns of schoolchildren with obesity and body adiposity. Methods: A cross-sectional study was carried out with 378 children aged 8 and 9 years, enrolled in urban schools in the
city of Viçosa, Minas Gerais, Brazil. A semi-structured questionnaire was applied to the children and their caregivers on sociodemographic characteristics and life habits. Three 24‑hour food recalls were used to identify dietary patterns; the Principal Component Analysis was employed. Weight and height were measured for the calculation of the body mass index (BMI) of the children and their mothers, waist circumference and neck circumference. Body composition was also evaluated through dual-energy X-ray absorptiometry (DXA). For all performed tests, the level of significance was set at 5%. Results: Five dietary patterns (DP) were identified: “unhealthy”, “snacks”, “traditional”, “industrialized” and healthy”.
There was an association between excess weight (prevalence ratio [PR]: 1.38, 95% confidence interval [95%CI]: 1.02 to 1.87) and body fat (PR: 1.32, 95%CI : 1.07 to 1.64) with industrialized DP. There was an association between excess body fat (PR: 1.31, 95%CI: 1.01 to 1.74) and lower adherence to traditional DP. The other patterns were not associated with obesity and body adiposity. Conclusion: Children with excess weight and body adiposity showed greater adherence to the industrialized DP and lower adherence to the traditional DP. We suggest that early assessments of dietary habits should be  undertaken for monitoring and modifying these habits when necessary.

Bacupari (Garcinia brasiliensis) extract modulates intestinal microbiota and reduces oxidative stress and inflammtion in obese rats

Fernanda de Oliveira Araújo, Maria Eliza de Castro Moreira, Renata Celi Lopes Toledo, Andressa Rodrigues de Souza, Marcelo Henrique dos Santos, Eliana Carla Gomes de Souza, Hilario Cuqueto Mantovani, Hércia Stampini Duarte Martino
Food Research International, v.122, p. 199-208
Impact factor: 3.086

Abstract: The objective of this study was to evaluate the effects of an ethanolic extract of the bark of bacupari (Garcinia brasiliensis – EEB) on the abundance of intestinal microbiota, concentration of short-chain fatty acids (SCFAs), oxidative stress, and inflammation in obese rats fed a high-fat diet (HFD). Male Wistar rats were divided into three groups: an HFD-fed obese control group, a group fed HFD plus EEB (BHFD) at a dose of 300 mg per animal per day (42 mg 7-epiclusianone and 10.76 mg morelloflavone), and a lean control group fed an AIN-93 M diet for 8 weeks. EEB decreased (p < 0.05) the abundance of organisms belonging to the phyla Firmicutes and Proteobacteria, and increased (p < 0.05) the concentration of propionic acid. Liver concentrations of malondialdehyde, nitric oxide, resistin, and p65 nuclear factor-kappa B p65(NF-κB) decreased (p < 0.05), while the expression of heat shock protein (HSP)72 and catalase increased (p < 0.05) with the consumption of EEB. Moreover, computational molecular modeling studies involving molecular docking between the main constituents of EEB, 7-epiclusianone and morelloflavone, and NF-κB suggested its inhibitory activity, thus corroborating the experimental results. The consumption of EEB may therefore be a promising strategy for the beneficial dietary modulation of the intestinal ecosystem, thereby countering oxidative stress and inflammation in obese rats. This activity is attributable to the presence of bioactive compounds that act individually or synergistically in the scavenging of free radicals or in the inflammatory process

Body composition indices in brazilian adults: age-specific and sex-specific percentile curves

Cristiane Junqueira de Carvalho, Giana Zarbato Longo, Leidjaira Juvanhol Lopes, Patrícia Feliciano Pereira, Kátia Josiany Segueto, Brunnella Alcantar Chagas de Freitas, Andreia Queiroz Ribeiro
Archives of endocrinology and metabolism, v. 25, p. 1-11
Cites per doc/2: 1.194

Abstract: Objective: To establish percentile curves for measures and indices of body composition by age and sex and compare them with data from other ethnic groups. Subjects and methods: Cross-sectional, population-based study with adults aged 20-59 years (n = 689). Percentile curves adjusted by a third degree polynomial function were constructed for skeletal mass index (SMI), fat mass index, body fat, and load-capacity metabolic indices (LCMI) based on dual-energy X-ray absorptiometry (DXA). Results: SMI weight and SMI BMI showed decline from the third decade of life in both sexes, whereas SMI height was not able to identify lean mass loss over the ages studied. There was a slight drop at the end of the fifth decade (50-59 years) in men. Among Americans and Chinese, the 50th percentile curve of SMI height showed an earlier decline. The estimates of adiposity and LCMI curves peaked between 40-49 years and Americans and Chinese maintained an upward curve throughout adulthood. Conclusion: The data and curves showed that the SMI adjusted for BMI and body weight were more adequate in detecting the decline of lean mass in adults due to aging. In contrast, SMI height had a positive correlation with age and its curve increased throughout the evaluated age groups. The results contribute to the evaluation to the nutritional status of adults and to the prevention and treatment of outcomes related to adiposity and deficit lean mass.

Built urban environment and functional incapacity: enabling healthy aging

Aline Siqueira Fogal, Milene Cristina Pessoa, Elpídio Inácio Fernandes Filho, Andréia Queiroz Ribeiro
Journal of Transport & Health, v. 14, p 1-6
Impact factor: 2.583

Abstract: Background: This study aimed to assess the associations among neighborhood walkability and functional disability in older adults. Methods: The study included a community-based, random sample of 410 community-dwelling adults aged≥60 years old in Viçosa, Minas Gerais, Brazil. The dependent variable was functional disability, which was assessed by investigating the difficulty in performing or the requirement of help to perform the activities of daily living (ADLs) and instrumental activities of daily living (IADLs). Older adults with functional disability were those who reported difficulty in performing six or more activities or a complete inability to perform at least three activities. The environmental are also evaluated. Confounding variables were selected using directed acyclic graphs, and multilevel logistic regression models were used to test the associations between the variables. Results: Older adults living in areas with higher walkability had lower odds ratios for functional disability, even after adjustment for possible confounding variables. Conclusions: While additional research is required to evaluate these neighborhood features in more detail and determine the causality, promoting simple changes in the built environment may be more effective in minimizing disability as the population ages than the efforts to change risk factors at the individual level.

Changes in oxidative stress markers and cardiometabolic risk factors among Roux-en-Y Gastric Bypass patients after 3 and 12 months post-surgery follow-up.

Sônia Lopes Pinto, Leidjaira Juvanhol Lopes, Leandro Licursi de Oliveira, Rodolfo Castilho Clemente, Josefina Bressan
Surgery for Obesity and Related Diseases v.2019, p. 1-8
Impact Factor: 3.758

Abstract: Background: Evidence shows potential reduction in oxidative stress after Roux-en-Y gastric bypass. However, this outcome can vary, with postsurgery time, type of markers significantly altered, and possible relation with cardiometabolic risk markers, thus indicating the need for more studies. Objective: To evaluate changes in oxidative stress and its relation with cardiometabolic risk markers in Roux-en-Y gastric bypass patients after 3 and 12 months postsurgery. Setting: Federal University of Viçosa, Brazil. Methods: All data were collected before surgery and after 3 and 12 months postsurgery. Biochemical data were collected, and insulin resistance was determined by homeostasis model assessment of insulin resistance, triglyceride/glucose index, and triglycerides/high-density lipoprotein cholesterol. Additionally, catalase, superoxide dismutase, ferric-reducing antioxidant power, nitric oxide, carbonylated protein, and malondialdehyde were analyzed. Results: After 3 months postsurgery, excess weight loss was 46%. It increased to 82% after 12 months. We observed a significant reduction in levels of serum insulin, triglycerides, homeostasis model assessment of insulin resistance, triglyceride/glucose index, and triglycerides/high-density lipoprotein cholesterol indices and nitric oxide, throughout the entire study period. Also, reduced levels of total cholesterol, low-density lipoprotein, serum glucose, malondialdehyde, and superoxide dismutase were observed at 3 and 12 months postsurgery compared with baseline. On the other hand, reduction in ferric-reducing antioxidant power occurred only at 3 months postsurgery. We also observed that nitric oxide was positively correlated with triglycerides, percent excess weight loss, total cholesterol/high-density lipoprotein cholesterol, and triglyceride/glucose index. Conclusion: Roux-en-Y gastric bypass is able to reduce oxidative stress, insulin resistance, and improve lipid profile after 3 and 12 months postsurgery. Furthermore, changes in oxidative stress and cardiometabolic risk markers are correlated.

Chia Seed (Salvia hispanica L.) as a Source of Proteins and Biactive Peptides with Health Benefits: a review

Mariana Granciere, Hércia Stampini Duarte Martino, Elvira Gonzales de Mejia
Comprehensive Reviews In Food Science And Food Safety, v 18, p. 480-499
Impact factor: 5.974

Abstract: The consumption of chia seed (Salvia hispanica L.) has increased in recent years due its high content of omega-3 fatty acids and dietary fiber. This seed also has a high concentration of proteins and essential amino acids, becoming a promising source of bioactive peptides. The objective of this review was to identify the composition and the beneficial effects of chia seeds (S. hispanica L.), their proteins, peptides, and their potential impact on human health. The UniProt database was used to identify the chia proteins and their amino acid sequences. The BIOPEP database was used to analyze the peptides’s bioactive potential. A total of 20 proteins were cataloged in chia seed, 12 of those were involved in the regular metabolic processes of the plant cells. However, eight proteins were specifically related to production and storage of plant lipids, thus explaining the high concentration of lipids in chia seeds (around 30%), especially omega-3 fatty acids (around 20%). The analyses of amino acid sequences showed peptides with bioactive potential, including dipeptidyl peptidase-IV inhibitors, angiotensin-converting enzyme inhibitors, and antioxidant capacity. These results correlated with the main health benefits of whole chia seed in humans such as antioxidant capacity, and hypotensive, hypoglycemic, and anticholesterolemic effects. Such relation can be associated with chia protein and peptide compositions and therefore needs further investigation in vitro and in vivo.

Chia (Salvia hispanica L.) Seed Total Protein and Protein Fractions Digests Reduce Biomarkers of Inflammation and Atherosclerosis in Macrophages In Vitro.

Mariana Grancieri, Hercia Stampini Duarte Martino, and Elvira Gonzalez de Mejia
Molecular Nutrition & Food Research, v.2019, p.1-15
Impact Factor: 4.653

Abstract: Scope: The objectives are to evaluate the anti-inflammatory and anti-atherosclerotic effects of digested total protein and digested protein fractions from chia seed in macrophages in vitro. Methods and results: Total protein and protein fractions (albumin, globulin, glutelin, and prolamin) are isolated from chia seed and digested using simulated gastrointestinal conditions, resulting in digested total protein (DTP) and igested protein fractions (DPF). DTP and DPF are applied (1.0 mg mL−1) in RAW 264.4  macrophages stimulated with LPS (1 μg mL−1) for inflammation or ox-LDL (80 μg mL−1) for atherosclerosis. In the inflammatory process, DTP and DPF reduce p-NF-κB, iNOS, p-JNK, and AP-1. Digested glutelin reduces the secretion of nitric oxide (65.1%), reactive oxygen species (19.7%), prostaglandins (34.6%), TNF-α (24.1%), MCP-1 (18.9%), IL-6 (39.6%), and IL-10 (68.7%). DTP and DPF reduce the NF-κB translocation to nuclei. DTP and digested glutelin reduce iCAM expression (86.4%, 80.8%), LOX-1 (37.3%, 35.7%), iNOS (67.0%, 42.2%), and NF-κB (57.5%, 71.1%). DTP is effective in reducing secretion of nitric oxide (43.4%), lipid accumulation (41.9%), prostaglandins (41.9%), TNF-α (43.3%), MCP-1 (47.6%), and IL-6 (50.5%). Peptides from chia DTP and DPF are also characterized. Conclusion: DTP and digested glutelin from chia seed reduce expression and secretion of markers related to inflammation and atherosclerosis pathways.

Common bean protein hydrolysate modulates lipid metabolism and preventsendothelial dysfunction in BALB/c mice fed an atherogenic diet

Mariana Juste Contim Gomes, Sâmara Letícia Silva Lima, Natália Elizabeth Galdino Alves, Andressa Assis, Maria Eliza Castro Moreira, Renata Celi Lopes Toledo, Carla Oliveira Barbosa Rosa, Olívia Teixeira, Priscila Z.Bassinello, Elvira Gonzales de Mejía, Hércia Stampini Daurte Martino
NMCD Nutrition, Metabolism and Cardiovascular Diseases, v.2019, p 1-32.
Impact factor: 3.340

Abstract: Common beans (Phaseolus vulgaris L.) protein hydrolysate is a source of bioactive peptides with known health benefits. The aim of this study was to evaluate the effect of common bean protein hydrolysate on lipid metabolism and endothelial function in male adult BALB/c mice fed an atherogenic diet for nine weeks. Male adult mice were divided into three experimental groups (n = 12) and fed with normal control diet; atherogenic diet and atherogenic diet added with bean protein hydrolysate (700 mg/kg/day) for nine weeks. Food intake, weight gain, lipid profile, Atherogenic Index of Plasma, inflammation biomarkers and endothelial function were evaluated. APH group presented reduced feed intake, weight gain, lipid profile, tumor necrosis factor-α, angiotensin II (94% and 79%, respectively) and increased endothelial nitric oxide synthase (62%). Protein hydrolysate showed hypocholesterolemic activity preventing inflammation and dysfunction of vascular endothelium, in addition to decreasing oxidative stress, indicating an adjuvant effect on reducing atherogenic risk.

Comparison of different household food security assessment methods in the rural area of a Brazilian city

Luiza Veloso Dutra, Dayane de Castro Moraes, Ricardo Henrique Santos, Sylvia do Carmo Castro Franceschini, Silvia Eloiza Piore
Revista Brasileira de Estudos de População, v.35, p.1-17

Abstract: Aim: To evaluate and compare household food security situations in the rural area of a Brazilian city by three different methods: Availability of food energy at home, nutritional status and Perception of food insecurity. Methods: Cross-sectional study of 79 families living in 19 rural communities in a small city in Minas Gerais, Brazil, including a total of 272 residents. Families were selected by drawing lots, respecting the proportionality of families per community. The inclusion criteria included living in rural areas, inhabiting a selected household, and using food products available for consumption, by purchase and production. During family visits, nutritional status was analyzed by anthropometry, the perception of food insecurity by Food Insecurity Scale (EBIA) and availability of food energy at household for 30 days. Results: Of the 79 families of family farmers, 12.7% were considered to be unsafe for availability of food energy at household, 24.0% due to the presence of low weight at the household and 49.5% by EBIA. There was a low correlation among the methods, with differences between them (Kendall W 0.162 p <0.001). Food insecurity was associated to the presence of at least one individual aged less than 18 years old in the household. Food security classified according to EBIA was associated with an increase in the number of people living in the household, the production of vegetables and fruits. Conclusions: No single indicator can cover several dimensions of food security. Food Security involves a broad and multifaceted approach; therefore, its thorough evaluation requires different classification methods.

Concomitant exercise training attenuates the cardioprotective effects of pharmacological therapy in a murine model of acute infectious myocarditis

Andréa A.S. Mendonça, Reggiani V. Gonçalves, Thaiany G. Souza-Silva, Izabel R.S.C. Maldonado, André Talvani, Antônio J. Natali, Rômulo D. Novaes
Life Sciences, v.230, p.141-149
Impact factor: 3.448

Abstract: When administered alone, preinfection exercise training and benznidazole-based chemotherapy induce cardioprotection in Chagas disease. However, the effect of concomitant exercise and benznidazole treatment is unknown. We investigated whether exercise and specific chemotherapy could interact to modulate parasitemia, inflammation, redox status and heart damage in a murine model of T. cruzi infection. Wistar rats were randomized into an uninfected control group (CNT) and four groups infected with T. cruzi: sedentary untreated (SUN) and treated (STR), and trained untreated (TUN) and treated (TTR). Running training was administered 5 days/week for 4 weeks. Treated animals concomitantly received 100 mg/kg/day benznidazole. Heart inflammation and reactive damage were not detected in CNT animals. Compared to SUN, TUN animals presented increased levels of parasitemia, myocarditis, nitric oxide, hydrogen peroxide, protein carbonyl, malondialdehyde, cytokines (IFN-γ, TNF-α, IL-4, IL-6, IL-10 and IL-17), catalase, superoxide dismutase and glutathione reductase activity, as well as reduced heart non-protein antioxidant levels (P < 0.05). TTR animals exhibited higher levels of parasitemia, myocarditis, hydrogen peroxide, malondialdehyde, IFN-γ, TNF-α and IL-6 than STR animals (P < 0.05), which showed the lowest levels of all analyzed parameters compared to the other groups (P < 0.05). Our findings indicate that exercise aggravates acute infection. When concomitantly administered with benznidazole, exercise training impaired parasitic control and chemotherapy-induced cardioprotection in T. cruzi-infected rats. Considering that exercise training and T. cruzi infection constitute independent metabolic challenges, the negative effects of concomitant treatment are potentially related to the overlapping oxidative and immunoinflammatory demands of exercise and the infection itself

Consumption of sweetened beverages and associated factors in adults

Danielle Cristina Guimarães da Silva, Wellington Segheto, Ninive de Almeida Reis, Milene Cristine Pessoa, Juliana farias de Novaes, Giana Zarbato Longo
Ciência e saúde Coletiva, v. 24, p. 899-906
Impact Factor: 0.78o

abstract: The aim of this study was to evaluate the regular consumption of sweetened beverages and its association with sociodemographic and behavioral aspects in a city in the southwest of Brazil. It involves is a population-based study of 1,226 adults aged 20 to 59 living in the urban area of the municipality of Viçosa in the state of Minas Gerais. A structured questionnaire to measure sociodemographic and behavioral conditions was applied. The consumption of sweetened beverages was considered regular when the frequency of consumption was five or more times a week. Regular consumption of sweetened beverages was higher in men and women aged between 20 and 29 years
(p < 0.01). Men with the habit of eating meals in front of the television (p = 0.03) and women dissatisfied with their weight (p = 0.03) consumed greater regular amounts of sweetened beverages. The conclusion reached is that older individuals showed less regular consumption of sweetened beverages and that the consumption of same was associated with obesogenic behaviors, such as the habit of eating meals in front of the television and among individuals dissatisfied with their body weight.

Dietary folate intake is negatively associated with excess body weight in brazilian graduates and postgraduates (CUME PROJECT)

Gabriela Amorim Pereira, Josefina Bressan, Fernando Luiz Oliveira, Helena Maria Pinheira Sant’Ana, Adriano Marçal Pimenta, Lilian Lelis Lopes, Helen Hermana Miranda Hermsdorff
Nutrients, v.11, p. 518-529
Impact factor: 3.550

Abstract: Folate, vitamin B6, and vitamin B12 intake can be important regulators for obesity development. Thus, we investigated the possible association between the intake of these vitamins and the excess body weight or obesity prevalence in the participants of the Cohort of Universities in Minas Gerais (CUME project). This study analyzed cross-sectional data of 2695 graduates and postgraduates from universities in the state of Minas Gerais (801 men, 1894 women, ages 36.2 ± 9.4). The first step consisted of collecting data online, and the second step consisted of blood collecting in the subsample living in the city of Viçosa and its region (Minas Gerais). Excess body weight and obesity prevalence were 38.1% and 10.1%, respectively. Inadequate intake of folate, B6, and B12 were 12, 6.3, and 11.1%, respectively. Beans/lentils and French bread presented the highest contribution to folate intake (23.45% and 10.01%, respectively). Those individuals in the third tertile for folate intake ( ≥ 511.12 μg/d) had a lower excess body weight [prevalence ratio (PR): 0.79, confidence interval (CI): 0.71–0.8] and obesity prevalence (PR: 0.60, CI: 0.45–0.78). These associations were maintained when the sample was categorized by sex. In addition, serum folate was positively associated with dietary folate (p for trend = 0.032) and negatively associated with serum homocysteine (p for trend = 0.003) in the subsample. Dietary folate intake was negatively associated with excess body weight and obesity in CUME participants, indicating the relevance of this vitamin dietary assessment.

Dietary inflammatory index and prevalence of overweight and obesityin Brazilian graduates from the Cohort of Universities of Minas Gerais (CUME project).

Thatianne Moreira Silva Oliveira, Josefina Bressan, Adriano Marçal Pimenta, Miguel-Angel Martınez-Gonzalez, Helen Hermana Miranda Hermsdorff
Nutrition, v. 2019, p. 1-33
Impact factor: 1.703

Abstract: Objectives: to evaluate the independent association of Dietary Inflammatory Index (DII®) score with overweight and obesity in Brazilians participants of the Cohort of Universities of Minas Gerais (CUME project). Research Methods & Procedures: cross-sectional study with 3,151 graduates and postgraduates (2,197 women) with a mean (SD) age of 36.3 (± 9.4) years. Sociodemographic characteristics, lifestyle and anthropometric data were assessed by online self-reported questionnaire. In addition, a validated food frequency questionnaire (FFQ) with 144 food items was used to generate Energy-adjusted DII (E-DII) scores, which evaluated the inflammatory potential of the diet. Results: the prevalence of overweight and obesity were 28.2% and 11%, respectively. Participants in the highest E-DII quartile (most pro-inflammatory diet) were more likely
to be smokers/ex-smokers; sedentary; and consumers of fat, red and ultraprocessed meats, fats and oils (excluding olive oil), bottled fruit juices and soft drinks, sugars, sweets and higher overall caloric intake, when compared to the first quartile of E-DII. Both men and women in the fourth E-DII quartile had the highest prevalence of overweight and obesity (PR = 1.35;95% CI: 1.14-1.59 and PR = 1.97; CI: 1.20-3.22, respectively, in men; PR = 1.38; 95% CI: 1.17-1.65 and PR = 1.95; CI: 1.31-2.90, respectively, in women). Conclusion: the most pro-inflammatory dietary pattern was associated with a higher prevalence of overweight and obesity, as well as other unhealthy lifestyles, including sedentariness, smoking, and obesogenic diet.

Dietary inflammatory index is associated with excessive body weight and dietary patterns in subjects with cardiometabolic risk

Talitha Silva Meneguelli , Jéssica Viana Hinkelmann, Juliana Farias de Novaes, Carla de Oliveira Barbosa Rosa, Mariana De Santis Filgueiras, Brenda Kelly Souza Silveir, Nitin Shivappa, James R Hebert, Helen Hermana Miranda Hermsdorff
Journal of Food and Nutrition Research, v. 7, p. 491-499
Impact factor: 0.927

Abstract: Unhealthy eating habits can trigger chronic inflammation in organs and tissues, and subsequent cardiovascular risk. Thus, this study aimed to evaluate the potential association of Dietary Inflammatory Index (DII™) score with cardiometabolic risk factors and a priori and a posteriori dietary patterns in adults and elderly Brazilians (42 ± 16 years) from a health care program. This cross-sectional study was carried out with 248 individuals (138 women and 110 men) from a Cardiovascular Health Care Program of the Universidade Federal de Viçosa (PROCARDIO-UFV, ReBEC ID number: RBR-5n4y2g). Sociodemographic and clinical characteristics, lifestyle and anthropometric data were assessed by standardized protocols. DII scores were calculated from a 24 h-recall, and dietary patterns were determined by a posteriori method, as Principal Component Analysis (PAC), and a priori method, as Healthy Eating Index (HEI). The mean DII was 0.15 ± 0.84. The subjects included in the most pro-inflammatory category(3rd tertile) were more likely to be individuals with excessive body weight, increased waist-to-hip ratio and lower quality diet assessed by PAC and HEI. The most pro-inflammatory diet was associated with excessive body weight as well as other worse dietary patterns

Dietary intake as a predictor for all-cause mortality in hemodialysis subjects (NUGE-HD study).

Karla Pereira Balbino, Leidjaira Juvanhol Lopes, Andreza de Paula Santos Epifânio, Luciane Domingos Marota, Josefina Bressan, Helen Hermana Miranda Hermsdorff
Plos One, v. 14, p.1-12
Impact factor: 2.776

Abstact: This study aimed to identify the factors capable of mortality prediction in patients on hemodialysis, using a prospective cohort with three years of follow-up. We hypothesized that lack of clinical-metabolic control, impairment of nutritional status, and inadequate food consumption are risk factors for mortality in this population. This is a longitudinal study on a non-probabilistic sample of 85 adults and elderly patients undergoing hemodialysis, aged � 18 years (66.0% male, 61.6±13.7 years). Data on anthropometric, biomarkers, body composition and food intake were obtained. Predictors of mortality were evaluated using Cox regression analysis. During the three years follow-up, 16 patients (18.8%) died. We observed that age (HR = 1.319, CI 95% = 1.131–1.538), calcium-phosphorus product (HR = 1.114, CI 95% = 1.031–1.205), ferritin (HR = 1.001, CI 95% = 1.001–1.002), nitric oxide (HR = 1.082, CI 95% = 1.006–1.164), and vitamin C intake (HR = 1.005, CI 95% = 1.001–1.009) were positively associated with mortality. Serum iron (HR = 0.717, CI 95% = 0.567–0.907), triceps skinfold thickness (HR = 0.704, CI 95% = 0.519–0.954), lean mass (HR = 0.863, CI 95% = 0.787–0.945), and the ratio of dietary monounsaturated/polyunsaturated fat (HR = 0.022, CI 95% = 0.001–0.549) were independent negative predictors of mortality. Our results suggest that dietary intake is also a predictor of mortality in patients on hemodialysis, besides nutritional status, body composition, oxidative stress, inflammation, and bone metabolism, indicating the importance of evaluation of these factors altogether for better prognosis

Dietary non-nutrients in the prevention of non-communicable diseases: potentially related mechanisms.

Priscila Vaz de Melo Ribeiro, Patricia Amaro Andrade, Helen Hermana Miranda Hermsdorff, Rosângela Minardi Mitre Cotta, Carla de Oliveira Barbosa Rosa
Nutrition, v.2019, p 1-24.
Impact factor: 3.420

Abstract: Among the ten leading causes of death in developed countries are chronic non-communicable diseases (NCD). The impact of these multifactorial diseases on public health has stimulated considerable research aimed at investigating the primary risk factors associated with these diseases (genetic factors, stress, food intake, and amount of physical exercise). Thus, healthful foods (e.g., fruits, vegetables, oils, grains, and seeds) are sources of bioactive compounds that promote good health and disease prevention. Among them, non-nutrients (polyphenols, phytosterols, saponins, and phytates) are non-caloric substances capable of modulating metabolic pathways, maintaining health, and preventing NCD.The performance of some non-nutrients isdemonstrated and reviewed in this work, such as theirantioxidant and anti-inflammatory action, modulationof the anti-atherogenic lipid profile (higher HDL-c, lower ox-LDL and triacilglycerols), reduction of glucose and fat intestinal absorption, increase in insulin sensitivity, and stimulation of NO synthesis.

Dietary patterns and body adiposity in children in brazil: a cross-sectional study.

Sarah Aparecida Vieira Queiroz, Cristiana Santos Andreoli, Poliana Cristina de Almeida Fonseca, Helen Hermana Miranda Hermsdorff, Patricia Feliciano Pereira, Andreia Queiroz Ribeiro, Silvia Eloiza Priore, Sylvia do Carmo Castro Franceschini
Public Health, v. 166, p. 140-147
Impact factor: 1.538

Abstract: Objectives: Many factors are associated with the increase in total and central body adiposity in children, especially eating habits. This has led to an increasing number of studies analysing food patterns, which consider the synergistic effect of food and nutrient intake on the nutritional status. The objective of this study was to identify the dietary patterns of children aged 4–7 years and associate these with different indicators of total and central body adiposity. Study design: Cross-sectional study- Methods: The study consisted of 403 children from a retrospective cohort in Minas Geraes, Brazil. Four indicators of body adiposity were evaluated: body mass index (BMI), waist-to-height ratio (WHtR) and percentages of total and central body fat (assessed by dual-energy X-ray absorptiometry). The dietary habits of the children were evaluated by identifying the dietary patterns using principal component analysis. The adjustment predictor variables were related to the socio-economic characteristics, lifestyle and duration of exclusive breastfeeding. Food patterns were identified by factor analysis. Linear regression was used to estimate the regression coefficient and the confidence interval, considering statistical significance of α = 5%. Results: Five dietary patterns were identified, which explained 42.3% of the data variance: ‘Traditional’, ‘Unhealthy’, ‘Milk and chocolate’, ‘Snack’ and ‘Healthy’. The multiple linear regression model showed that a greater adherence to the ‘Traditional’ and ‘Unhealthy’ patterns was related to higher BMI, WHtR, and total and central body adiposity. Conclusion: Children with a higher intake of food from the ‘Traditional’ and ‘Unhealthy’ patterns showed an increase in total and central body adiposity.

Dietary patterns and metabolic phenotypes in brazilian adults: a population-based cross-sectional study.

Dayana Ladeira Macedo Pereira, Giana Zarbato Longo, Danielle Cristina Guimarães da Silva, Leidjaira Juvanhol Lopes
Public Health Nutrition, v. 22, p.1-7
Impact factor: 2.526

Abstract: Objective: Dietary patterns have been pointed out as useful diet quality indicators, but evidence about their relationship to metabolic phenotypes is still scarce. Thus, the present study aimed to verify the relationship between dietary patterns and metabolic phenotypes in Brazilian adults. Design: Cross-sectional study. A food consumption frequency questionnaire assessed food consumption profiles. Metabolic phenotypes were defined based on the criteria of the National Health and Nutrition Examination Survey: overweight or normal weight and metabolically healthy (MHOW and MHNW) or unhealthy (MUOW and MUNW). Dietary patterns were established through exploratory factor analysis and principal component analysis. The associations were tested using multinomial logistic regression. Setting: Viçosa, Minas Gerais, Brazil. Participants: Individuals (n 896) aged 20–59 years of both sexes, selected using probabilistic sampling. Results: Three dietary patterns were identified: Unhealthy pattern (alcoholic beverages, oils and fats, condiments, soda and juice, sugars and sweets, snacks, and meat and derivatives), Traditional pattern (culinary preparations, beans, milk and dairy products, and coffee and tea) and Healthy pattern (vegetables and fruits, whole grains, chicken and fish, and skimmed milk). Unhealthy pattern was positively associated with the MHOW and MUOW phenotypes in the fourth quartile (OR = 1·84; 95 % CI 1·06, 3·22) and in the third (OR = 1·94; 95 % CI 1·11, 3·39) and fourth (OR = 2·56; 95 % CI 1·41, 4·64) quartiles of consumption, respectively. Healthy pattern was also associated with these phenotypes. Conclusions: Both the pattern comprising energy-dense foods and the healthier pattern were associated with overweight phenotypes among Brazilian adults

Dietary total antioxidant capacity is positively associated with muscular strength in cirrhotic outpatients: a cross-sectional study.

L. de Freitas Lima, F. de Faria Ghetti, Helen Hermana Miranda Hermsdorff,2 D. G. de Oliveira, G. Teixeira, L. E. V. Castro Ferreira1 & Ana Paula Boroni Moreira
Journal of Human Nutrition and Dietetics, v. 2019, p.1-8
Impact factor: 3.088

Abstract: Background: Cirrhosis is the end-stage of progressive fibrosis, in which oxidative stress and inflammation-related pathways can modulate the cellular and tissue events involved in the pathogenesis of liver fibrosis. Dietary intake of antioxidants has been suggested to protect against oxidative damage and related clinical complications. The present study aimed to investigate the potential association of the dietary total antioxidant capacity (dTAC) with anthropometric, functional and biochemical markers, as well as the severity of the disease, in cirrhotic outpatients. Methods: Sixty-two outpatients (38 men and 24 women) with a mean (SD) age of 59.1 (9.9) years were evaluated. Dietary TAC was estimated from a food frequency questionnaire. Aetiology and severity of liver cirrhosis, lifestyle characteristics, occurrence of comorbidities and oedema, and anthropometric, functional and biochemical markers were all assessed. Results: Cirrhotic outpatients with higher dTAC also had higher values of the hand-grip strength (P = 0.029) and arm muscle area (P = 0.027). After adjusting by sex, age, smoking and alcohol intake, the addition of 1 mmol day 1 of dTAC contributed to increase 0.552 kg f 1 in hand-grip strength (P < 0.05). The addition of one mmol day 1 of dTAC contributed to an arm muscle area increase 0.565 cm2 (P < 0.05) on average. Conclusions: The dTAC was positively associated with hand-grip strength and arm muscle area in cirrhotic outpatients. The implications of the present study are important in clinical practice because a diet rich in antioxidants may be an ally in the control of excessive reactive oxygen species production

Digested total protein and protein fractions from chia seed (Salvia hispanica L.) had high scavenging capacity and inhibited 5-lox, cox-1-2, and inos enzymes.

Mariana Granciere, Hércia Stampini Duarte Martino, Elvira Gonzales de Mejia
Food chemistry, v.289, p. 204-214
Impact factor: 4.529

Abstract: The objective was to identify and characterize peptides from digested total protein (DTP) and isolated proteinfractions (DPF), and their potential antioxidant, anti-inflammatory and anti-atherosclerotic effects, from chiaseed (Salvia hispanica L.). Total protein and protein fractions from chia seed underwent simulated gastrointestinal digestion. The sequence, physicochemical properties, and biological potential of peptides were determined using chemical, in silico, and biochemical assays. Peptides from DTP (n = 9) and DPF albumin (n = 12), globulin (n = 11), prolamin (n = 5) and glutelin (n = 17) had interaction with cyclooxygenase-2 (COX-2), p65- nuclear factor kappa B, lipoxygenase-1 (LOX-1) and toll-like receptor 4 (p < 0.05). DTP, and digested albumin, globulin, and glutelin showed scavenging capacity for superoxide, hydrogen peroxide, nitric oxide and DPPH (1,1-diphenyl-2-picrylhydrazyl), and inhibition of 5-LOX, COX-1-2, and inducible nitric oxide synthase (iNOS) enzymes (p < 0.05). Chia seed proteins has peptides with potential beneficial health effects highlighting the importance of chia consumption.

Discriminatory ability of new and traditional anthropometric indices for hypertension and diabetes in the elderly

Fabiane Aparecida Cannan Rezende, Andreia Queiroz Ribeiro, Patricia Feliciano Pereira, Silvia Eloiza Priore, João Carlos Bouzas Marins, Sylvia do Carmo Castro Franceschini
Journal of Gerontology & Geriatric Medicine, v. 5, p. 1-6

Abstract: Purpose: To investigate the association and discriminatory ability of new and traditional anthropometric indices for diabetes and hypertension in elderly. Materials and methods: We conducted a cross-sectional population-based study of 62 elderly aged 60 years or more. Body Mass Index (BMI), Waist Circumference (WC), Hip Circumference (HC), Waist to Hip Ratio (WHR), Waist to Height Ratio (WHtR), Conicity Index (CI), Waist to Calf Ratio (WCR), Waist to Hip to Height Ratio (WHHR), Body Adiposity Index (BAI), A Body Shape Index (ABSI) and Body Roundness Index (BRI) were obtained. The outcomes were hypertension and diabetes. Poisson regression with robust variance estimator was used to estimate the prevalence ratios. Adjustors were age, sex, income, level educational, alcohol consumption, smoking status, physical activity and diet quality score. To assess discriminatory ability was used receiver operating characteristic curve. Results: Most of the anthropometric indices were positively associated with both diabetes and hypertension. The prevalence of diabetes were increased more than 1.5-fold per SD increase for WCR and WHR (P <0.0001). Hip circumference showed an inverse association with diabetes. The areas under the curve were significantly greater than 0.5 (P <0.05). WCR (AUC: 0.67, 95% CI: 0.62-0.72), WHtR (AUC: 0.66, 95% CI: 0.61-0.72) and BRI (AUC: 0.66, 95% CI: 0.6z-0.72) showed discriminatory ability slightly higher for diabetes. Conclusion: New anthropometric indices did not show stronger associations or better discriminatory ability than the traditional anthropometric indices for hypertension or diabetes in elderly individuals.

Does aerobic exercise associated with tryptophan supplementation attenuates hyperalgesia and inflammation in female rats with experimental fibromyalgia?

Rafael Marins Rezende, Maria do Carmo Gouveia Peluzio, Hércia Stampini Duarte Martino, Antônio José Natali
Plos One, v.14, p.1-14
Impact factor: 2.806

Abstract: The objective of this study was to verify the effects of aerobic exercise associated with tryptophan (TRP) supplementation on hyperalgesia, as well as on cortisol, IL-6 and TNF concentrations in female rats with experimental fibromyalgia (FM). Female Wistar rats (initial body weight: ~ 350 g; age: 12 months) were randomly divided into 5 groups: CON (Control); F (Fibromyalgia induced); FE (Fibromyalgia induced plus exercise); FES (Fibromyalgia induced plus exercise and TRP supplementation) and FS (Fibromyalgia induced plus TRP supplementation). Fibromyalgia was induced with two injections (20 μL) of acidic saline (pH 4.0) into the right gastrocnemius muscle with a 3-day interval. Control animals received the same doses of neutral saline (pH 7.4). The exercised animals underwent progressive lowintensity aerobic exercise (LIAE) on a treadmill (10–12 m/min, 30–45 min/day, 5 days/week) for three weeks. During this period, the supplemented animals received a TRP supplemented diet (210 g/week), while the others received a control diet. Mechanical hyperalgesia was evaluated weekly and serum cortisol and muscle IL-6 and TNF concentrations were assessed after three weeks of interventions. Experimental FM caused bilateral hind paw hyperalgesia and augmented serum cortisol and muscle IL-6 concentrations. After 3 weeks of interventions, LIAE alone reduced hyperalgesia (151%) and reduced serum cortisol concentrations (72%). Tryptophan supplementation itself diminished hyperalgesia (57%) and reduced serum cortisol concentrations (67%). Adding TRP supplementation to LIAE did not further reduce hyperalgesia significantly (11%), which was followed by an important decrease in muscle IL-6 concentrations (68%), though reduction in serum cortisol pulled back to 45%. Muscle TNF concentrations were not affected. In conclusion, the association of TRP supplementation to LIAE does not potentiate significantly the reduction of bilateral mechanical hyperalgesia promoted by LIAE in female rats with experimental FM, however an important decrease in IL-6 is evident.

Eating habits, lifestyle and intestinal constipation in children aged four to seven years

Cristiana Santos Andreoli, Sarah Aparecida Vieira Ribeiro, Poliana Cristina Almeida Fonseca, Sonia Machado Rocha Ribeiro, Sylvia do Carmo Castro Franceschni
Nutrición Hospitalaria, v. 36, p. 25-31
Impact factor: 0.759

Abstract: Objective: to investigate the association between intestinal constipation, lifestyle and eating habits in four to seven year old children. Methods: a cross-sectional study with a sample of 152 children aged four to seven years old. Intestinal constipation was characterized according to the Rome IV criteria. Excess weight was classified by the body mass index. Variables that could be associated with constipation, such as maternal constipation, lifestyle, food and water intake, were selected. In the analysis, the prevalence ratio using Poisson regression, with a robust variance and statistical significance was set at p < 0.05. Results: the prevalence of intestinal constipation was 32.2% (n = 49), of which 34.7% (n = 17) of the children were overweight. As for lifestyle, 73% of the children did not practice any regular physical activities and approximately 60% spent more than two hours a day in sedentary activities, such as watching television or playing electronic games. A statistically significant association was found between constipation and daily school time equal to or greater than 4.5 hours (p = 0.007), non-consumption of fruits (p = 0.003) and greens (p = 0.007) and regular intake of fried food (p = 0.003). Conclusion: an association between intestinal constipation and unhealthy habits, such as non-consumption of fruits and vegetables, and regular consumption of fried food was observed. Preventing intestinal constipation requires changes in the lifestyle and eating habits of the children and family.

Effect of combined physical exercise on anthropometric and biochemical indicators of cardiometabolic risk in university students

Lucimar Aguiar da Silva, Deyliane Aparecida de Almeida Pereira, Silvia Eloiza Priore
Revista Brasileira de Nutrição Esportiva, v.13, p.1-6

Abstract: Coming into university can influence the habits of young people, contributing to the increased risk of disease. The objective of the study was to verify the effect of combined physical exercise on anthropometric measurements, body composition and biochemical tests. A study of 61 female students (18-25 years old) from a public university. Anthropometric evaluation, body composition and biochemical examinations were performed before and after participating in the activities of a combined exercise program. The data obtained in the two moments were compared to each other. There was a reduction in the values of perimeter of the neck and waist, in the neck/thigh ratios, waist/hip, waist/height and waist/thigh, in the glucose values, HDL, in the cholesterol/HDL ratio, and in adipose tissue, and increase in muscle tissue. The present study demonstrates the importance of offering physical activity programs in the academic environment, aiming at improving physical activity patterns and promoting current and future health.

Effects of aerobic exercise on the inflammatory cytokine profile and expression of lipolytic and thermogenic genes in Β1-AR−/− mice adipose tissue

Aurora Correa Rodrigues, Helen Hermana Miranda Hermsdorff, Maria do Carmo Gouveia Peluzio, Thales Nicolau Primola, Antônio José Natali
Life Science, v.221, p. 224-232
Impact factor: 2.936

Abstract: Aim: Investigate the effects of moderate continuous aerobic exercise (MCAE) on the inflammatory cytokine profile and expression of lipolytic and thermogenic genes in β 1 -AR −/− mice adipose tissue. Main methods: Four- to five-month-old male wild type (WT) and β 1 -AR −/− mice were divided into groups: WT control (WTc) and trained (WTt); and β 1 -AR −/− control (β 1 -AR −/− c) and trained (β 1 -AR −/− t). Animals from trained groups were submitted to a MCAE regimen (60 min/day; 60% of maximal speed, 5 days/week) on a treadmill, for 8 weeks. After euthanasia, white epididymal (eWAT) and inguinal (iWAT) and brown (BAT) adipose tissues were dissected and used to determine: adiposity index; adipocyte histomorphometry; cytokine concentration; and gene expression. The content of fat, protein and water of the empty carcass was determined. Key findings: MCAE reduced body weight, fat mass as well as iWAT and BAT adipocyte area in β 1 -AR −/− animals. Aerobic exercise also diminished the concentrations of pro-inflammatory (IL-12p70, TNF-α, IL-6) and anti-inflammatory (IL-10) cytokines in adipose tissue (iWAT, eWAT or BAT) of β 1 -AR −/− mice. However, MCAE hadno effect on the expression lipolytic and thermogenic genes in β 1 -AR −/− mice adipose tissue. Significance: Alongside reductions in body weight, fat mass and adipocyte area eight weeks of MCAE improves the profile of inflammatory cytokines in β 1 -AR −/− mice adipose tissue, despite no change in Lipolytic and thermogenic gene expression.

Effect of reducing dietary advanced glycation end products on obesity-associated complications: a systematic review

Priscila Vaz de Melo Ribeiro, Juliana Ferreira Tavares, Mirian Aparecida de Campos Costa, Jéssica Bevenuto Mattar, Rita de Cássia Gonçalves Alfenas
Nutrition Reviews, v. 2019, p.1-10
Impact factor: 5.779

Abstract: Context: Consumption of dietary advanced glycation end products (AGEs) is associated with oxidative stress, inflammation, and other chronic conditions commonly associated with obesity. Objective: To analyze the effects of dietary AGEs on complications associated with obesity. Data sources: This systematic review was conducted and reported according to PRISMA guidelines. The PubMed, Cochrane, and Scopus databases were searched, using the terms “advanced glycation end products,” “overweight,” and “obesity.” The last search was performed in October 2018. Data extraction: Six studies that evaluated the effects of low-AGE and high-AGE diets were included in the review. The duration of the studies ranged from 1 day to 12 weeks. A comparison of all the compiled data was conducted by the authors. Data analysis: Circulating and urinary AGE markers, besides soluble receptor for AGEs, were considered as the primary outcomes. The secondary outcomes were cardiometabolic, inflammatory, glycemic, anthropometric, and renal markers. Conclusions: AGE-RAGE interactions can activate the NF-κB (nuclear factor kappa B) signaling pathway and inhibit the PI3K-AKT pathway in adipocytes, which may explain their association with chronic diseases. This interaction can be considered as a novel explanation for the pathogenesis of obesity. AGEs can also be used as a biomarker for monitoring responses to dietary interventions in overweight and obese people

Effects of chia (Salvia hispanica L.) on calcium bioavailability and inflammation in Wistar rats.

Bárbara Pereira da Silva, Renata Celi Lopes Toledo, Mariana Grancieri, Maria Eliza Castro Moreira, Natalia Medina Ramirez, Neuza Maria Brunoro Costa, Hércia Stampini Duarte Martino
Food Research International, v. 116, p. 592-599
Impact factor: 3.086

Abstract: hia is a good source of calcium, however it is not been previously reported its bioavailability associated with an inflammatory condition. Thus, the present study evaluated the effect of chia on calcium bioavailability, inflammation, and oxidative stress in Wistar rats fed a high-fat diet or standard diet for 35 days. Chia consumption resulted in lower calcium balance and calcium absorption and retention rates. In addition, the urinary calcium concentration was lower in groups that were fed chia. The bone resistance of animals feed chia was lower than that in rats fed the standard diet receiving calcium carbonate. Animals that were fed chia showed lower total, very low-density lipoprotein, and low-density lipoprotein cholesterol levels than animalsfed calcium carbonate. Animals fed standard diet showed higher superoxide dismutase plasma concentrations than animals in the high fat calcium carbonate group. PPAR-α protein levels were higher in animals fed chia whereas TNF-α and IL-10 were lower in these animals. NFκB mRNA expression and protein levels were lower in the groups that received chia compared with HFD + CC. Chia intake presented low calcium bioavailability regardless of the type of diet
consumed and was able to improved inflammation and the lipid profile in young Wistar rat. Besides this, the consumption of this seed increased the activity of antioxidants enzymes.

Effects of chia (Salvia hispanica L.) on oxidative stress and inflammation in ovariectomized adult female in Wistar rats

Bárbara Pereira da Silva, Renata Celi Lopes Toledo, Marcela Duarte Villas Mischima, Maria Eliza Castro Moreira, Neuza Maria Brunoro Costa, Hércia Stampini Duarte Martino
Food & Function, v.10
Impact factor: 3.241

Abstract: The present study investigated the influence of chia consumption on inflammation, oxidative stress, and lipid profiles in adult female ovariectomized rats fed a high-fat diet. Forty ovariectomized and 40 intact (SHAM) rats were allocated into 8 groups (n = 10), and each rat received one of the following four diets: standard diet (ST); standard diet + chia (STC); high-fat diet (HF); and high-fat diet + chia (HFC) for 126 days. Biochemical parameters and biomarkers of lipid peroxidation, inflammation, and oxidative stress were evaluated. The mRNA expression levels of PPAR-α, NFκB, TNF-α and Zn-SOD1 were analyzed, as well as those of TNF-α and IL-1β. Chia intake increased HDL cholesterol (HDL-c) and reduced LDL cholesterol (LDL-c) levels. Plasma catalase activity was elevated in the STC group. Concentrations of TBARS were higher in all groups fed HF. PPAR-α mRNA expression was elevated, and levels of NFκB mRNA expression were reduced in the STC group. mRNA expression and protein levels of TNF-α were lower in rats fed the standard diet. Protein levels of IL-1β were reduced in rats fed the standard diet, and the high fat diet with chia. In general, ovariectomy did not influence the inflammatory and oxidative stress parameters. Chia intake improved antioxidant activity by increasing SOD expression, PPAR-α expression, catalase activity, and HDL-c levels. In addition, chia consumption decreased the concentrations of the inflammatory markers IL-1β and LDL-c.

Efect of vitamin A suplementation: a systematic review

Marcela Martins Soares, Mariane Alves Dias, Luciana Saraiva da Silva, Glauce Dias da Costa, Raquel Maria Amaral Araújo, Rosangela Minardi Mitre Cotta
Ciência e Saúde Coletiva, v. 24, p.827-838
Impact factor: 0.780

Abstract To evaluate the effect of vitamin A supplementation in postpartum infants and women on serum retinol levels and breast milk. The databases Medline, PubMed, Lilacs and SciELO were consulted. The descriptors used were vitamin A, dietary supplement, child, postpartum period, infant and nutrition programs policies. Search found 7432 articles. After elimination of duplicity and application of eligibility criteria, 8 studies remained. All evaluated the effect of vitamin A supplementation on immediate postpartum, five studies used retinyl palmitate supplementation, one with retinyl palmitate and two did not specify the form of supplementation. Six studies evaluated colostrum and two included supplementation of children. It was found that supplementation in the puerperium increases the concentrations of serum retinol and breast milk, however, this result was in the short term and was relevant when the previous concentrations of the mother were low. When maternal serum concentrations are adequate, the retinol content in milk does not change, with little relevance for children. Further studies should be performed to evaluate the effect of megadoses supplementation on serum concentrations of children

Effects of high-oleic peanuts within a hypoenergetic diet on inflammatory and oxidative status of overweight men: a randomised controlled trial

Ana Paula Silva Caldas, Raquel Duarte Moreira Alves, Helen Hermana Miranda Hermsdorff, Leandro Licursi de Oliveria, Josefina Bressan
British Journal of Nutition, v. 2019, p. 1-8
Impact factor: 3.319

Abstract: The consumption of food with MUFA has been associated with improvement of inflammation and oxidative stress in overweight individuals. In the present study, we evaluate the effect of high-oleic peanut intake within a hypoenergetic diet on inflammatory and oxidative status markers in overweight men. Sixty-four overweight men (BMI 26–35 kg/m2, 18–50 years old) participated in this randomised controlled study for 4 weeks, allocated into three groups: control (CT, n 22), conventional peanut (CVP, n 21) and high-oleic peanut (HOP, n 21). They followed a hypoenergetic diet (−250 kcal/d; −1045 kJ/d) with or without 56 g of high-oleic or conventional peanuts. After the intervention, the inflammatory markers did not show significant changes in fasting concentrations or postprandial response among the experimental groups (P > 0·05). The activity of oxidative status markers remained unchanged after the intervention. However, in the CT, malondialdehyde showed lower concentration in comparison with the baseline (P = 0·020) and among the groups (P = 0·002). In the present study, the daily intake of high-oleic peanuts within a hypoenergetic diet did not modify the inflammatory markers and oxidative status in overweight men. More studies are needed to better understand the effect of high-oleic peanut intake on health outcomes

The hidden hunger and fibromyalgia: A systematic review

Rafael Marins Rezende, Antônio José Natali, Sylvia do Carmo Castro Franceschini
Revista Chilena de Nutricion, v. 46, p. 160-167

Abstract: Recently the possibility of a causal link between fibromyalgia (FM) and micronutrient deficiency , a type of malnutrition known as “hidden hunger”, has been suggested. However, the results are controversial, which raises questions and debates on the actual influence of “hidden hunger” on the development of FM. In this review, we present and discuss scientific evidence related to micronutrient deficiencies and FM, highlighting key micronutrients involved. We searched PubMed and Science Direct databases for all observational studies published between 2000 to March 2017. We selected fourteen observational studies, eight studies aimed at linking vitamin D deficiency to the presence of FM and six studies focused on the association of mineral deficiency with FM. The association between vitamin D deficiency and increased pain sensitivity in FM is suggested, although such insufficiency is also associated with other chronic musculoskeletal disorders. It appears that mineral deficiency (e.g., iron, magnesium, manganese, zinc and calcium) plays an important role in the onset of FM and its main symptoms.

Endemic disease control agents’ perception on the fight against Aedes aegypti and the prevention of arbovirus infections in Brazil.

Cintia Pereira Donateli, Ariadne Barbosa do Nascimento Einloft, Rosângela Minardi Mitre Cotta, Glauce Dais da Costa
Plos Neglected Tropical Diseases, v.13, p.1-15
Impact Factor: 4.449

Abstract: Background Arboviruses pose a serious and constant threat to public health, and have demanded surveillance efforts worldwide. The prevention of arbovirus transmission depends on effective measures to control vectors and promote health. The objective of this study was to examine
the factors that enhance and impair the endemic disease control agents’ field work, based on their own perspective. Methodology and main findings In 2017, 65 ACE of seven municipalities participated in a series of seven focus groups in the Zona de Mata mesoregion (Minas Gerais, Brazil). The focus groups were organized aiming to broaden and deepen the discussion and analysis of ACE perception of their performance in relation to attributions, work processes, training, continuous education, and evaluation. All the workers, irrespective of municipality, recognize their role in disease prevention and health promotion, however they suffer from a reductionist stigma associated with their profession. Also, internal and external factors such as infrastructure, resources, administrative management, and the work process affect the quality of service delivered and job satisfaction.
Practice challenges include incompatible demands such as refusal by residents and high sense of insecurity related to violence. The respondents reported that success of their activities depend on the population. Conclusions/Significance The recurrence of epidemics demands effective vector control policies. Therefore, the performance of these professionals as regards surveillance needs to be reassessed. Public awareness and acknowledgement of the role of ACE in the identification of risk and health protection factors are indispensable for the improvement of this workforce.

Environmental factors associated with obesity in the adult population in a medium-sized Brazilian city

Fernanda Maria Oliveira da Silva, Taiane Gonçalves Novaes, Andreia Queiroz Ribeiro, Giana Zarbato Longo, Milene Cristine Pessoa
Cadernos de Saúde Pública, v.35, p.1-14
Impact factor: 1.170

ABSTRACT: The aim of this study was to estimate associations between environmental variables and obesity in the adult population in a medium-sized Brazilian city. This was a cross-sectional study with individual data from a population-based study and environmental data obtained by direct observation, later georeferenced by the addresses. The sample included 965 adults 20 to 59 years of age, and the study used anthropometric, socioeconomic, demographic, behavioral, and self-rated health data. The outcome variable was obesity, defined as body mass index (BMI) ≥ 30kg/m2. Retail food outlets were classified as: supermarkets and establishments with a predominance of healthy, unhealthy, and mixed foods. Settings for physical activity were categorized as public and private. Characterization of the social environment used the census tracts’ per capita income in tertiles and the crime rate. Binary logistic regression analysis was performed according to the generalized estimating equations model. An inverse association was found between density of public and private locations for physical activity and obesity (OR = 0.95, 95%CI: 0.92-0.99; OR = 0.98, 95%CI: 0.97-0.99) in models adjusted by individual and environmental variables. In all the models, the highest per capita income tertile was inversely associated with obesity (p ≤ 0.05). The food environment and crime rates were not independently associated with obesity. These findings suggest that the census tract’s income and its environment for physical activity can orient public policies to decrease obesity in this city.

Evaluation of lifestyle of female adolescents through latent class analysis approach

Valter Paulo Neves Miranda, Paulo Roberto dos Santos Amorim, Eliana Rodrigues de Faria, Sylvia do Carmo Castro Franceschini, Sílvia Eloíza Priore
BMC Public Health, v.19 p. 184-196
Impact factor: 2.265

Abstract: Background: Lack of regular physical activity, high sedentary behavior and presence of unbalanced alimentary practices are attitudes associated with an inadequate lifestyle among female adolescents. Objective: to assess the lifestyle of female adolescents based on measurements of behavioral variables. Methods: Cross-sectional study with 405 female adolescents between 14 and 19 years old, resident and attending public schools in Viçosa (state of Minas Gerais). Their lifestyle was analyzed by the Physical Activity Recall, number of steps, screen time (ST), cellphone time (CT), sitting time, food frequency questionnaire (FFQ), and alcohol and tobacco consumption. With multiple correspondence analysis it was possible to observe dispersion and approximation of the variables’ categories. Latent class analysis (LCA) was used for modeling the “lifestyle” variable, having been conducted in the poLCA (Polychromous Variable Latent Class Analysis) package of the R statistical software. Results: The mean age was 15.92 ± 1.27 years. Most of the adolescents were considered physically inactive (78%) and with low number of steps (82.57%); 41.45% reported not performing Moderate to Vigorous Physical Activities (MVPA) adequately. Sedentary behavior was found high when assessing ST (72.90%) and CT (65.31%). It was found the best fitted latent class model for the lifestyle (p-G 2 = 0.055, p-χ 2 = 0.066) featured three latent classes and one covariate (alcohol): Class 1, ‘Inactive and Sedentary’ (γ = 77.5%); Class 2, ‘Inactive and Non-sedentary lifestyle (γ=16.31%); and Class 3, ‘Active and sedentary’ (γ=6.19%). Female adolescents that had ‘never consumed alcohol’ were 2.26 times as likely (log OR = 0.8174; p = 0.033) to belong to class 3 (Active & Sedentary lifestyle) than to class 1 (Inactive & Sedentary lifestyle). Conclusion: Latent class analysis model with five manifest variable (MVPA, number of steps, ST, sitting time and number of meals) and alcohol consumption like covariate showed itself to be an accurate and objective method in the assessment of female adolescents’ lifestyle. Female adolescents that had ‘never consumed alcohol’ were more as likely to belong to class ‘Active & Sedentary lifestyle’ than to class Inactive & Sedentary lifestyle. An inactive and sedentary lifestyle is coupled to other unhealthy behaviors during adolescence, possibly carrying over into adult life.

Exclusive breast-feeding and sociodemographic characteristics are associated with dietary patterns in children aged 4-7 years

Sarah Aparecida Vieira, Poliana Cristina de Almeida Fonseca, Cristiana Santos Andreoli, Helen Hermana Miranda Hermsdorff, Andreia Queiroz Ribeiro, Patricia Feliciano Pereira, Silvia Eloisa Priore, Sylvia do Carmo castro Franceschini
Public Health Nutrition, v.22, p. 1398 – 1405
Impact factor: 2.485

Abstract: Objective: To identify the dietary patterns of children aged 4–7 years and verify their association with sociodemographic characteristics, lifestyle habits and exclusive breast-feeding (EBF). Design: A cross-sectional study nested within a cohort, performed with Brazilian children aged 4–7 years. The children were re-evaluated at age 4 to 7 years and food patterns were identified a posteriori through principal component analysis. The predictive variables were related to socio-economic characteristics, lifestyle habits and duration of EBF. Setting: Viçosa, Minas Gerais, Brazil. Participants: Representative sample of 403 children followed up by the Lactation Support Program from the Extension Program of the Universidade Federal de Viçosa during the first 6 months of life. Results: Five dietary patterns were identified: ‘Traditional’, ‘Unhealthy’, ‘Milk and chocolate’, ‘Snack’ and ‘Healthy’. Children who did not receive EBF until they were at least 4 months old had a higher adherence to the ‘Unhealthy’ and ‘Snack’ patterns, and older children also consumed more ‘Unhealthy’ foods. The highest income was associated with the highest consumption of foods of the patterns ‘Unhealthy’, ‘Milk and chocolate’ and ‘Healthy’. Conclusions: In view of the results, we emphasize the importance of providing support and encouragement towards EBF in the first months of life, as it can positively influence lifelong eating habit

Extruded sorghum (Sorghum bicolor L.) improves gut microbiota, reduces inflammation, and oxidative stress in obese rats fed a high-fat diet.

Andressa Rodrigues de Sousa, Maria Eliza de Castro Moreira, Mariana Grancieri, Renata Celi Lopes Toledo, Fernanda de Oliveira Araújo, Hilário Cuquetto Mantovani, Valéria Aparecida Vieira Queiroz, Hercia Stampini Duarte Martino
Journal of Functional Foods, v. 58, p 282-291.
Impact factor: 3.197

Abstract: The aim of this study was to investigate the effects of extruded sorghum flour (ESF) on rats fed with a high-fat diet (HFD) on gut microbiota modulation, inflammation, and oxidative stress. Male Wistar rats were fed a normal diet (AIN-93 M, n=8), HFD (n=8), or HFD plus ESF replacing 50% cellulose and 100% corn starch (HFDS50, n=8) or HFD plus ESF replacing 100% cellulose and 100% corn starch (HFDS100, n=8) for eight weeks. ESF improved the composition of intestinal microbiota by increasing the proportion of the Bacteroidetes phylum instead of the Firmicutes phylum. Furthermore, ESF reduced the concentrations of p65 NF-κB in liver, seric resistin, lipids peroxidation and increase the total antioxidant capacity of plasma, the expression of superoxide dismutase, and the heat shock protein 72. In conclusion, ESF improves the intestinal dysbiosis, inflammation and oxidative stress in obese rats fed a hyperlipid diet.

Family dyslipidemia and associated factors with changes in lipid profile in children

Natalia Aparecida de Souza, Sarah Aparecida Veira Ribeiro, Poliana Cristina de Almeida Fonseca, Cristiana Santos Andreoli, Silvia Eloisa Priore, Sylvia do Carmo Castro Franceschini
Ciência e saúde Coletiva, v. 24, p. 325-334
Impact factor: 0.780

Abstract This article aimed to assess the prevalence of dyslipidemia and associated factors in children aged from 4 to 7 years old. It is a
cross-sectional study conducted with 402 children aged from 4 to 7 years old, accompanied by a Lactation Support Program in the first six
months of life. We measured total cholesterol, triglycerides and high-density lipoprotein (HDL) and low-density lipoprotein (LDL). We selected the variables that could be associated with the lipid profile, such as the family history of dyslipidemia, nutritional status and food consumption of children. We performed Poisson regression analysis with robust variance. The level of significance adopted was p<0.05. We observed increased LDL values in 46.8% (188), total cholesterol in 37.6% (151), triglycerides in 10.4% (42) and below-desirable HDL in 33.8% (136) of the children. There was a statistically significant association between the family history of dyslipidemia with total cholesterol, LDL and triglycerides (p<0.05 and p <0.001, respectively); Early weaning with LDL (p< 0.05); Sedentarism with LDL and triglycerides
(p < 0.05 and p < 0.001, respectively); as well as HDL with candy consumption (p < 0.05). There was a significant prevalence of changes in the lipid profile of the children. Nutrition education activities and programs aimed at this group are needed.

Food and nutritional insecurity in families in the Brazilian rural environment: a systematic review

Paula Torres Trivelato, Dayane de Castro Morais, Elisangela da Silva, Silvia Oliveira Lopes, Sylvia do Carmo Castro Franceschini, Silvia Eloisa Priore
Ciência e Saúde Coletiva, v. 24, p. 865-874.
Impact factor: 0.780

Abstract: This review sought to analyze food and nutritional insecurity in the Brazilian rural environment, and the measurement instruments used to assess this situation. A systematic review was conducted in the SciELO, PubMed and CAPES databases, using the search terms: ‘food security’ and ‘rural,’ Subsequently, a reverse search was performed in the 12 articles selected. The inclusion criteria were: original articles related to food and nutritional (in)security in the Brazilian rural population. Twelve studies were included. Most of them used the Escala Brasileira de Insegurança Alimentar – EBIA (Brazilian Scale for Food Insecurity) and socioeconomic questionnaires to assess food insecurity (FI), an association being found between them. Five studies addressed the nutritional aspect by anthropometry but found no association with FI. Food consumption was assessed by four studies and an association was detected. The results show a high prevalence of FI in rural areas in relation to the population analyzed in the Pesquisa Nacional por Amostra de Domicílio – PNAD (National Household Sample Survey) in
the years 2009 and 2013, as well as a high prevalence of severe FI. The conclusion reached is that the rural environment is vulnerable, mainly regarding food and nutritional issues and the associated socioeconomic determinants.

High calcium intake from fat-free milk, body composition and glycaemic control in adults with type 2 diabetes: a randomised crossover clinical trial

Júnia Maria Geraldo Gomes, Jorge de Assis Costa, Priscila Vaz de Melo Ribeiro, Rita de Cássia Gonçalves Alfenas
British Journal of Nutrition, v. 2019, p.1-8
Impact factor: 3.319

Abstract: We evaluated the effects of high-Ca fat-free milk v. low-Ca control diet on adiposity and on glycaemic control. Fourteen subjects with type 2 diabetes (aged 49·5 (sd 8·6) years, BMI 29·4 (sd 4·5) kg/m2, low habitual Ca consumption (<600 mg/d)) were included in this randomised, crossover clinical trial. Subjects participated in two 12-week experimental sessions (high-Ca fat-free milk (HC) or low-Ca control (LC)) separated by 8-week washout. Subjects daily consumed in the laboratory a breakfast shake containing 700 mg (HC) or 6·4 mg (LC) of Ca. Energy-restricted diets containing 800 mg of dietary Ca/d were prescribed. Dietary records data indicated the consumption of 1200 mg of Ca/d during HC and of 525 mg of Ca/d during LC. There was a greater reduction in body weight, body fat mass, waist circumference and waist:hip ratio after HC. Serum 25-hydoxyvitamin D and homeostatic model assessment-2 β-cell function (HOMA2-%B) increased, and serum uric acid, parathormone (PTH) and glycated Hb (HbA1c) concentrations reduced after HC. In addition, changes from baseline in terms of serum uric acid, glucose, HbA1c and PTH concentrations were lower, and those of HOMA2-%B, serum Ca and 25-hydoxyvitamin D were higher after the HC than after LC. The consumption of approximately three servings of fat-free milk and 1200 mg of dietary Ca/d enhanced weight loss, improved body composition and promoted glycaemic control in subjects with type 2 diabetes and low habitual Ca consumption (<600 mg/d).

Higher waist circumference is related to lower plasma polyunsaturated fatty acids in healthy participants: metabolic implications

Larissa Oliveira Chaves, Júlia Cristina Cardoso Carraro, Fernanda de Carvalho Vidigal, Josefina Bressan
Journal of the American College of Nutrition, v.38, p.1-9
Impact factor: 2.107

Abstract: Objective: We evaluated whether the relationship between waist circumference (WC) and cardiometabolic risk is related to usual diet and plasma fatty acid composition.
Methods: This cross-sectional study included 226 health professionals from 20 to 59 years old. Anthropometric features, oxidative stress, inflammatory markers, and plasma fatty acid profile were assessed. Dietary intake was evaluated with a semi-quantitative food frequency questionnaire, the quality of dietary habits by Healthy Eating Index, and insulin resistance by homeostasis model assessment–insulin resistance and triglyceride-glucose index. Results: Higher WC was associated with lower concentrations of high-density lipoprotein cholesterol (p¼0.000) and adiponectin (p¼0.000) and higher uric acid levels (p¼0.011). Plasma polyunsaturated fatty acid (PUFA) levels were negatively associated with weight (p¼0.046), systolic blood pressure (p¼0.035), fasting glucose (p¼0.000), triglyceride-glucose index (p¼0.023), and IL-1b (p¼0.037). Individuals with elevated WC consumed more calories (p¼0.002), niacin (p¼0.002), and pyridoxine (p¼0.017), but less calcium (p¼0.001), phosphorus (p¼0.016), and vitamin B2 (p¼0.011). In addition, individuals with higher WC denoted lower PUFA concentrations (p¼0.036). Conclusion: The results suggest that participants with higher WC have lower plasma PUFA concentrations and higher levels of saturated fatty acids. This could be related to metabolic and inflammatory changes that could trigger increased risk of metabolic syndrome and cardiovascular disease.

Implementation of a brazilian cardioprotective nutritional (BALANCE) program for improvement on quality of diet and secondary prevention of cardiovascular events: a randomized, multicenter trial

Bernardete Weber, Ângela C. Bersch-Ferreira, Camila R. Torreglosa,  Aline Marcadenti, Josefina Bressan et al
The American Heart Journal, v. 215, p 187-197
Impact factor: 4.023

Abstract: Background Appropriate dietary recommendations represent a key part of secondary prevention in cardiovascular disease (CVD). We evaluated the effectiveness of the implementation of a nutritional program on quality of diet, cardiovascular events, and death in patients with established CVD. Methods In this open-label, multicenter trial conducted in 35 sites in Brazil, we randomly assigned (1:1) patients aged 45 years or older to receive either the BALANCE Program (experimental group) or conventional nutrition advice (control group). The BALANCE Program included a unique nutritional education strategy to implement recommendations from guidelines, adapted to the use of affordable and regional foods. Adherence to diet was evaluated by the modified Alternative Healthy Eating Index. The primary end point was a composite of all-cause mortality, cardiovascular death, cardiac arrest, myocardial infarction, stroke, myocardial revascularization, amputation, or hospitalization for unstable angina. Secondary end points included biochemical and anthropometric data, and blood pressure levels. Results From March 5, 2013, to Abril 7, 2015, a total of 2534 eligible patients were randomly assigned to either the BALANCE Program group (n = 1,266) or the control group (n = 1,268) and were followed up for a median of 3.5 years. In total, 235 (9.3%) participants had been lost to follow-up. After 3 years of follow-up, mean modified Alternative Healthy Eating Index (scale 0-70) was only slightly higher in the BALANCE group versus the control group (26.2 ± 8.4 vs 24.7 ± 8.6, P b .01), mainly due to a 0.5-serving/d greater intake of fruits and of vegetables in the BALANCE group. Primary end point events occurred in 236 participants (18.8%) in the BALANCE group and in 207 participants (16.4%) in the control group (hazard ratio, 1.15; 95% CI 0.95-1.38; P = .15). Secondary end points did not differ between groups after follow-up. Conclusions The BALANCE Program only slightly improved adherence to a healthy diet in patients with established CVD and had no significant effect on the incidence of cardiovascular events or death. (Am Heart J 2019;215:187-97.)

Increased c-reactive protein in brazilian children: association with cardiometabolic risk and metabolic syndrome components (PASE STUDY)

Lara Gomes Suhett, Helen Hermana Miranda Hermsdorff, Naruna Pereira Rocha, Mariane Alves Silva, Mariana de Santis Filgueiras, Luana Cupertino Milagres, Maria do Carmo Gouveia Peluzio, Juliana Farias de Novaes
Cardiology Research and Practice, v. 2019, p. 1-10

Abstract: C-reactive protein (CRP) is a marker of subclinical inflammation that has been found to be associated with cardiovascular disease risk. However, few studies have investigated the relationship between CRP and cardiometabolic markers in a representative sample of prepubescent children. The objective was to evaluate the high-sensitive CRP (hs-CRP) and its association with traditional and nontraditional cardiometabolic risk factors, as well as metabolic syndrome (MetS) components in Brazilian children. This is a cross-sectional representative study, with participants of the Schoolchildren Health Assessment Survey (PASE). Children from 8 to 9 years old (n 350) enrolled in public and private schools in the municipality of Viçosa, Minas Gerais, Brazil, were evaluated. Sociodemographic evaluation was performed through a semistructured questionnaire. Anthropometric, body composition, clinical, and biochemical measures were analyzed for cardiometabolic risk assessment. The total mean of serum hs-CRP concentration was 0.62 (±1.44) mg/L. hs-CRP was significantly correlated with several anthropometric, biochemical, and clinical parameters in this population (P < 0.05). hs-CRP was positively associated with the accumulation of cardiometabolic risk factors and MetS components (P < 0.05). Children with excessive weight; abdominal obesity; increased gynoid and android body fat; low HDL-c; hyperglycemia; and elevated uric acid, homocysteine, and apoB had higher chances of presenting increased hs-CRP (P < 0.05). In this study, Brazilian children with cardiometabolic risk already presented elevated serum hs-CRP concentration. hs-CRP was associated with the increase of traditional and nontraditional cardiometabolic risk factors, as well as the accumulation of MetS components.

Increased consumption of calcium from fat-free milk, energy-restricted diet and educational activities improves metabolic control in overweight type 2 diabetic patients

Jorge de Assis Costa, Junia Maria Geraldo, Priscila Vaz de Melo Ribeiro, Rita de Cássia Gonçalves Alfenas
British Journal of Nutition, v. 2019, p. 1-11
Impact factor: 3.319

Abstract: We assessed the effects of increased Ca consumption from fat-free milk in an energy-restricted diet and educational activities in the metabolic control of overweight type 2 diabetes mellitus (T2DM) patients. Fourteen subjects with T2DM (BMI 29·4 (SD 4·5) kg/m2, low habitual Ca consumption (<600 mg/d)) were included in this randomised, crossover clinical trial. Subjects were randomly allocated to one of the two interventions: drink containing 700 mg of Ca (DAIR) or drink containing 0 mg of Ca (CONT) for ninety consecutive days each. Energy-restricted diets (–500 kcal/d; –2092 kJ/d), containing 800 mg of Ca from dietary sources/d, were prescribed for both groups. Questionnaires were applied at baseline and at the end of the study to assess the subjects’ knowledge on the disease and on self-care, biochemical variables and physical activity. Blood pressure, food intake, body composition and anthropometry were assessed at baseline, days 45 and 90. There was a higher reduction of body fat %, waist circumference, hip circumference, neck circumference, waist:hip ratio, sagittal abdominal diameter, diastolic/systolic blood pressure and an increase in fat-free mass % in DAIR than in CONT. Uric acid, fasting glucose, Hb1Ac, parathyroid hormone and alanine aminotransferase concentrations reduced and vitamin D concentration increased after 90 d in DAIR compared with CONT. The consumption of energy-restricted diet containing 1200 mg Ca/d seems to favour metabolic control in subjects with T2DM. The educational activities increased the knowledge on the disease care.

Increase in protein intake after 3 months of rygb is an independent predictor for the remission of obesity in the first year of surgery

Sônia Lopes Pinto, Leidjaira Lopes Juvanhol, Josefina Bressan
Obesity surgery, v. 29, p 1-6
Impact factor: 3.603

Abstract: Introduction Although bariatric surgery promotes dietary changes, many questions regarding their effect on weight loss remain unanswered. Objective The aim of this study was to evaluate changes in dietary intake and predictive factors of obesity remission in the first 12 months after RYGB. Methods Fifty-one patients (mean 39.34 ± 9.38 years, 68.7% women) who underwent RYGB were included in this study. Dietary intake was evaluated through a 24-h dietary recall and subsequently classified by NOVA, macronutrients and calories. The predictive factors for obesity remission within 12 months after RYGB were evaluated by Cox regression. Results At baseline, 62.7%of the patients presented severe obesity; mean excess weight loss was greater than 80%after 1 year of surgery and about 70% of the patients were no longer diagnosed with obesity. An increase in percentage of calories from protein was observed at 3 and 12 months after surgery. The caloric contribution of ultra-processed foods was low at 3 months after surgery while that of unprocessed or minimally processed foods was high at 3 and 12 months after surgery. From the Cox regression analysis, preoperative BMI (HR, 0.78; 95%CI, 0.69–0.88) and age (HR, 0.94; 95%CI, 0.89–0.99) showed an inverse association with obesity remission. Also, Δ protein (at 3 months–baseline) showed a positive association with obesity remission (HR, 1.06; 95% CI, 1.01–1.12). Conclusion Lower preoperative BMI, lower age, and higher protein intake at 3 months after surgery may favor remission of obesity in up to 12 months compared with baseline.

Insufficient iodine intake in pregnant women in different regions of the world: a systematic review

Aline Carare Candido, Nubia de Souza de Morais, Luiza Veloso Dutra, Carina Aparecida Pinto, Sylvia do Carmo Castro Franceschini, Rita de Cássia Gonçalves Alfenas
Archives Of Endocrinology And Metabolism, v. 53, n.3, p. 306-311
Impact factor: 1.571

Abstract: Objective: To determine the prevalence of insufficient iodine intake in pregnant women. Materials and methods: The search was performed in the electronic databases Medline (PubMed), Latin American and Caribbean Literature in Health Sciences (Lilacs) and Scopus. Review studies, experimental studies, those with adolescent pregnant women (< 20 years) and iodine supplementation were excluded. The selection followed the steps of identifying the articles in the databases, deleting the duplicates, and reading the titles, abstracts, and then the entire article. The search for the articles occurred in September 2017, using the descriptors “pregnant” and “iodine deficiency” NOT “supplementation” in English, Portuguese and Spanish. Results: Thirteen articles were included, the deficiency prevalence ranged from 16.1% to 84.0%, and the median of iodine intake was insufficient in 75% of the studies. There is no classification for mild, moderate or severe levels of iodine deficiency in pregnant women, which makes it impossible to know the real dimension of the problem. Conclusion: The high prevalence of insufficient iodine intake in pregnant women, observed worldwide, shows the need for a population classification in order to direct public policies

Intestinal microbiota and colorectal cancer: changes in the intestinal microenvironment and their relation to the disease.

Sandra Aparecida dos Reis, Lisiane Lopes da Conceição, Maria do Carmo Gouveia Peluzio
Journal of Functional Foods, v. 53, p. 1-6
Impact factor: 3.144

Abstract: Tools that predict the risk of colorectal cancer are important for early diagnosis, given the high mortality rate for this cancer. The composition of the intestinal microbiota is now considered to be a risk factor for the development of colorectal cancer. This discovery has motivated a growing number of studies to identify the micro-organisms responsible for the onset and/or progression of colorectal cancer. With this in mind, this review discusses the relationship between the composition of the intestinal microbiota and colorectal cancer risk. Prospective and case–control studies indicate that the intestinal microbiota of individuals with colorectal cancer usually contains a greater proportion of bacteria responsible for gastrointestinal tract inflammatory diseases, as well as bacteria that produce toxins and carcinogenic metabolites. In contrast, there tends to be a reduced presence of butyric acid-producing bacteria, probiotic bacteria and potentially probiotic bacteria. Despite these differences, the onset and development of colorectal cancer cannot be attributed to a specific micro-organism. Thus, studies focused on the formation of the intestinal microbiota and factors that modulate its composition are important for the development of approaches for colorectal cancer prevention

Kefir reduces the incidence of pre-neoplastic lesions in an animal model for colorectal cancer.

Sandra Aparecida dos Reis, Lisiane Lopes da Conceição, Mariana de Moura e Dias, Nathane Paes Siqueira, Damiana Diniz Rosa, Leandro Licursi de Oliveira, Sérgio Luiz Pinto da Mata, Maria do Carmo Gouveia Peluzio
Journal of Medical Microbiology, v. 68, p.1391-1407
Impact factor: 1.926

Abstract: This study aimed to evaluate the effect of regular consumption of milk kefir on the development of pre-neoplastic colonic lesions. Thirty Wistar rats received water Control group) or milk (Milk group) or kefir (Kefir group) during five weeks. After that, colonic lesions were chemically induced and the treatments continued for more thirteen weeks. The regular consumption of kefir was able to reduce the incidence of aberrant crypt foci by 36%. Also, the consumption of kefir increased the cecal concentration of short chain fatty acids; reduced the lactulose/mannitol ratio; promoted an increase in the colonic concentration of TNF-α and IL-1β, and the enzyme catalase in comparison with the control group. Thus, kefir reduced the development of lesions, probably by increasing the
production of short chain fatty acids; reduction of intestinal permeability; immunomodulation and improvement of colonic antioxidant activity.

LINE-1 in Obesity and Cardiometabolic Diseases: A Systematic Review

Lilian Lelis Lopes, Helen Hermana Miranda Hermsdorff, Maria do Carmo Gouveia Peluzio, Josefina Bressan
Journal of the American College of Nutrition, v. 2019, p. 1-7
Impact factor: 2.175

Abstract: Epigenetic mechanisms may play an important role in the etiology of obesity and cardiometabolic diseases, by activating or silencing the related-genes. Scientific evidence has suggested that LINE-1 methylation is associated with body composition and obesity-related diseases, including insulin resistance, type 2 diabetes mellitus, and cardiovascular disease (CVD). It also has been evaluated as predictor of weight loss. The studies’ results are still conflicting, and positive and negative associations have been found to LINE-1 methylation regarding adiposity and cardiometabolic markers. Overall, this review presents observational (cross-sectional and longitudinal) studies and interventions (diet, exercises, and bariatric surgery) that evaluated the relationship of the LINE-1 methylation with obesity, weight loss, dyslipidemias, hypertension, insulin resistance, CVD, and metabolic syndrome.

Maternal polymorphisms in the FADS1 and FADS2 genes modify theassociation between PUFA ingestion and plasma concentrations of omega-3polyunsaturated fatty acids

Gisele Queiroz de Carvalho, Leticia de Nadai Marcon, Maria do Carmo Gouveia Peluzio
Prostaglandins, Leukotrienes and Essential Fatty Acids, v.150, p. 38-46
Impact factor: 2.864

Abstract: There is a lack of studies about polymorphisms in FADS genes in pregnant women. We aimed to verify the interaction between three FADS gene polymorphisms (rs174561; rs174575; rs3834458) and dietary α-linolenic acid (ALA) or linoleic/α-linolenic acid ratio (LA/ALA) and plasma concentrations of omega-3 (n−3) PUFAs in pregnant women. Of the 250 women evaluated, the homozygous for the rs174561 and rs3834458 minor allele had high plasma ALA concentrations at the highest ALA and LA/ALA ratio tertile (p < 0.05). Plasma concentrations of EPA and DHA were not influenced by diet. For the rs174575 SNP, pregnant women who carried the minor allele presented lower proportions of plasma EPA in the second LA/ALA ratio tertile (p < 0.05). Increased dietary intake of ALA and LA/ALA ratio promoted plasma ALA accumulation in homozygotes for the minor allele rs174561 and rs3834458. Moderate intake of LA/ALA ratio may reduce plasma concentration of EPA in pregnants carrying the rs174575 minor allele.

Metabolic Syndrome Among Young Health Professionals in the Multicenter Latin America Metabolic Syndrome Study

Barbara Vizmanos, Josefina Bressan, Fernanda de Carvalho Vidigal
Metabolic Syndrome and Related Disorders, v. 2019, p.1-10
Fator de impacto: 1.597

Abstract: Background: Metabolic syndrome (MS) and its components increase the risk of a number of chronic diseases. Evidence regarding its prevalence among health professionals, particularly in Latin America, is limited. The purpose of this study was to assess the overall prevalence of MS and its components among health professionals and students from five Latin American countries. Methods: A cross-sectional multicenter study entitled LATIN America METabolic Syndrome (LATINMETS) was conducted on five groups of apparently healthy volunteer subjects. Sociodemographic factors, lifestyle variables (smoking and physical activity), anthropometric measurements (weight, height, and waist circumference), standard biochemical analyses [triglycerides, glucose, and high-density lipoprotein cholesterol (HDLC)], and blood pressure measurements were assessed. MS was diagnosed based on internationally harmonized criteria. Associations between MS components and sociodemographic, lifestyle, and anthropometric variables were analyzed using multivariate logistic regression. Results: A total of 1,032 volunteers (n = 316-Mexico, n = 285-Colombia, n = 223-Brazil, n = 132-Paraguay, and n = 76-Argentina) were recruited. The majority of them were women (71.9%), students (55.4%), and younger than 28 years (67.2%). The overall prevalence of age-standardized MS was 15.5% (23.1% men and 12.2% women). The majority (59.3%) presented at least one MS component, mainly abdominal obesity (29.7%) and low HDL-C levels (27.5%). After adjusting for age and sex, MS and its components were positively associated with being overweight or obese. Conclusions: MS prevalence in this study was similar to that generally found among young populations in Latin-American countries. More than half of the sample had at least one MS component, suggesting that preventive measures and treatments aimed at achieving low-risk health status are essential in this population.

Neck circumference cutoff points to identify excess android fat

Mariana de Santis Filgueiras, Fernanda Martins de Albuquerque, Ana Paula Pereira Castro, Naruna Pereira Rocha, Luana Cupertino Milagres, Juliana Farias de Novaes
Jornal de Pediatria, v.2019, p.1-8
Impact factor: 2.081

Abstract: Objective: To evaluate the ability of neck circumference to identify excess android fat and to propose cutoff points for Brazilian children. Method: This was a cross-sectional study with 376 children aged 8 and 9 years enrolled in public and private schools in the urban area of the municipality of Viçosa, Minas Gerais. A semi-structured questionnaire containing sociodemographic and lifestyle information was applied. The following were collected: neck circumference, weight, and height for the calculation of body mass index. The percentage of fat in the android region was determined by dual energy X-ray absorptiometry. Linear regression analysis was used to evaluate the association between neck circumference and android fat, adopting a significance level of 5%. Receiver operating characteristic curves were used to evaluate the capacity of neck circumference to determine the excess android fat, as well as to estimate the cutoff points of neck circumference according to gender. Results: Multiple linear regression showed an association between neck circumference and android fat (ˇ: 2.94, 95% CI: 2.41, 3.47). Neck circumference was able to identify excess android fat in girls (AUC: 0.909, 95% CI: 0.999, 0.945) and boys (AUC: 0.938, 95% CI: 0.892, 0.968). The proposed cutoff points showed satisfactory sensitivity, specificity, and predictive values. Conclusions: Neck circumference is capable of identifying excess android fat in children and can be used in clinical practice and in population studies to determine central adiposity. The proposed cutoff points were satisfactory, but should be validated for other populations.

Nutritional Screening Tools Used and Validated for Cancer Patients

Nélia Pinheiro Mendes, Thalita Alves de Barros, Carla de Oliveira Barbosa Rosa, Sylvia do Carmo Castro Franceschini
Nutrition and Cancer, v. 29, p. 1-10
Impact factor: 2.447

Abstract: The purpose of this systematic review was to identify validated nutritional screening tools for cancer patients. The research was conducted in the electronic databases Pubmed, Cochrane Library, Scopus, and Biblioteca Virtual de Saúde (BVS), using the descriptors “Nutrition Assessment”, “Neoplasms”, and “Validation studies”. Initially, we identified 168 articles. After assessing eligibility, we included 21 studies. In selected studies, 14 nutritional screening tools were validation objects. The Patient-Generated Subjective Global Assessment (PG-SGA) showed better sensitivity, specificity and positive and negative predictive values (98, 82, 95, and 93%, respectively), as well as predictive of overall survival in cancer patients. In many countries, in addition to PG-SGA, the Nutrition Risk Screen (NRS-2002) is recommended for these patients. We did not identify, however, manuscripts that proposed validation. Validation studies of nutritional screening tools should be performed on patients with cancer, using representative samples of these individuals for better reliability of their results.

Potential of trace elements as supplements for the metabolic control of Type 2 Diabetes Mellitus: A systematic review

Luiza de Paula dias Moreira, Jaqueline Vieira Piovezana, Jéssica Bevenuto Matar, Larissa Oliveira Chaves, Hércia Stampini Duarte Martino
Journal of Funcitonal Food, v.57, p. 317-327
Impact factor: 3.144

Abstract: The objective of this review was to understand the role of trace elements in the form of supplements in metabolic control of Type 2 Diabetes Mellitus (T2DM). A systematic research was performed following PRISMA recommendations. Although 3236 studies were identified, only 18 studies composed of nine animal studies and nine clinical studies were included in this review. The included trace elements were Chromium (Cr), Selenium
(Se), Zinc (Zn) and Vanadium (V). The time, dose and type of supplement varied among the studies. Se, Cr, Zn and V improved glycemic profile and antioxidant status while Se, Cr and Zn affected lipid profile. Se and Zn supplementation improved endothelial function. Also, Se modified inflammatory profile. In general, cautious supplementation of trace elements promotes the metabolic control of T2DM.

Potential of trace elements as supplements for the metabolic control of Type 2 Diabetes Mellitus: A systematic review

Luiza de Paula dias Moreira, Jaqueline Vieira Piovezana, Jéssica Bevenuto Matar, Larissa Oliveira Chaves, Hércia Stampini Duarte Martino
Journal of Funcitonal Food, v.57, p. 317-327
Impact factor: 3.144

Abstract: The objective of this review was to understand the role of trace elements in the form of supplements in metabolic control of Type 2 Diabetes Mellitus (T2DM). A systematic research was performed following PRISMA recommendations. Although 3236 studies were identified, only 18 studies composed of nine animal studies and nine clinical studies were included in this review. The included trace elements were Chromium (Cr), Selenium
(Se), Zinc (Zn) and Vanadium (V). The time, dose and type of supplement varied among the studies. Se, Cr, Zn and V improved glycemic profile and antioxidant status while Se, Cr and Zn affected lipid profile. Se and Zn supplementation improved endothelial function. Also, Se modified inflammatory profile. In general, cautious supplementation of trace elements promotes the metabolic control of T2DM.

Process of Accreditation of Health Promoting Schools worldwide: A Systematic Review

Meirele Rodrigues Inácio da Silva, Alinne Paula de Almeida, Juliana Costa Machado, Luciana Saraiva da Silva, Glauce Dias da Costa , Rosangela Minardi Mitre Cotta
Ciência e Saúde Coletiva, v. 24, n.2, p. 475-486.
Impact factor: 0.780

Abstract: The scope of this article is to analyze the accreditation criteria of the studies that evaluated actions of health promotion and risk factor prevention of Health Promoting Schools (HPS). A systematic review was conducted based on the recommendations proposed in the “Preferred Reporting Items for Systematic Reviews and Meta-Analyses (Prisma)” protocol of articles that assessed HPS in the following databases: SciELO, Lilacs, Medline, PubMed and Portal Capes. From the analysis of the three pillars for accreditation of HPS, three of the studies analyzed did not include all the criteria for certification as HPS on the “Planning Process” and “Health Promotion Activities Developed” pillars. The schools cited in these studies perform health education, prevention and/or health promotion activities, however, it is misleading to refer to themselves as HPS. The main challenges for implementation, development and continuity of HPS were identified as
being intersectionality and insufficient financial and qualified human resources. HPS need to be certified and submitted to an ongoing evaluation process. It is also suggested the topic of health promotion be included in the syllabuses of training courses of health education teachers and other health education professionals.

Restrictive measure for the commercialization of antimicrobials in Brazil: results achieved

Josiane Moreira da Costa, Cristiano Soares de Moura, Aline Siqueira Fogal, Andreia Queiroz Ribeiro
Revista de Saúde Pública, v.53, p. 68-78
Impact factor: 1.968

Abstract: OBJECTIVE: To assess whether the incidence of hospital infection by a resistant microorganism decreased after the implementation of the restrictive measure of the National Health Surveillance Agency for the commercialization of antimicrobials. METHODS: A historical cohort study of medical records of adult patients admitted to a general and public hospital from May 2010 to July 2011. A cohort was formed with patients admitted in the period before the restrictive measure for the commercialization of antimicrobials (Phase I) and a second cohort was formed with patients admitted after the implementation of the restrictive measure (Phase II). RESULTS: The instantaneous risk of hospital infection by a resistant microorganism was estimated at seven by 1,000 people-time (95%CI 0.006–0.008) in Phase I, and four by 1,000 people-time (95%CI 0.003–0.005) in Phase II of the study. The differences between the survival curves in the different phases of the study and stratified by age group were also significant (p < 0.05). CONCLUSIONS: The results suggest that the implementation of the restrictive measure of the commercialization of antimicrobials by the National Health Surveillance Agency reduced the incidence of hospital infection by a resistant microorganism. DESCRIPTORS: Anti-Bacterial Agents. Prescription Drug Overuse, legislation & jurisprudence. Drug Resistance, Microbial. Drug Monitoring. Pharmacovigilance

Sedentary behavior and cardiovascular risk in children: a systematic review

Karina Lucia Ribeiro Canabrava, Paulo Roberto dos Santos Amorim, Valter Paulo Neves Miranda, Silvia Eloiza Priore, Sylvia do Carmo Castro Franceschini
Revista Brasileira de Medicina do Esporte, v. 25, p.433-441
Impact factor: 0.236

Abstract: In recognition of the increasing time spent in sedentary activities in modern life, an emerging area of study linking sedentary time to health has highlighted its role in the development of chronic diseases. Therefore, the objective of this systematic review was to investigate the indicators and characteristics of sedentary behavior associated with cardiovascular risk factors in children and adolescents. The databases SciVerse Scopus, MEDLINE®/PubMed and LILACS were selected as a source of reference, using the associated terms “sedentary lifestyle” or “sedentary behavior” or “sedentary” AND “cardiovascular diseases” AND “child or adolescent” to identify studies published from January 2006 to March 2019. The methodological quality of the studies was evaluated and a score was assigned. Fifty articles were included in this review at the end. Extensive sedentary time, especially greater screen and TV exposure time, were associated with cardiovascular risk factors. In addition, the accumulation of prolonged sedentary bouts with few breaks in sedentary time tended to compromise the cardiometabolic profile. These findings highlight the importance of differentiating and considering these various indicators and characteristics of sedentary behavior. Further studies are needed to elucidate the multiple and overlapping facets of sedentary behavior and their relationship with health, and to encourage the development of evidence-based recommendations for this population

Sociodemographic and lifestyle factors are associated with diet quality in cardiometabolic risk subjects.

Brenda Kelly Souza Silveira, Juliana Farias de Novaes, Nínive de Almeida Reis, Arieta Carla Gualandi Leal, Helen Hermana Miranda Hermsdorff
Journal of Food and Nutrition Research, v. 7, n. 2, p. 141-147
Impact factor: 1.950

Abstract:We investigated the association of social and lifestyle factors with diet quality in a cardiometabolic risk population. Cross-sectional data was from 265 subjects (aged 42 ± 16 years) attended at the Cardiovascular Health Care Program – PROCARDIO UFV (ReBEC identifier: RBR-5n4y2g). A 24-hour recall was applied and the Revised Healthy Eating Index (R-HEI) was calculated. Socioeconomic and lifestyle data were collected by chart analysis. Women (PR = 1.02, 95% CI: 1.01, 1.04), elderly (PR = 1.05, 95% CI: 1.02, 1.15), and those who eventually drink alcohol (PR = 1.02, 95% CI 1.01, 1.15) presented better diet quality (R-HEI> 70.8 points). Single subjects (PR = 0.89, 95% CI: 0.82, 0.98) and those with higher educational status (PR = 0.90, 95% CI 0.82, 0.98) presented lower score. Women had better scores on milk and dairy products, fruits and sodium. The elderly (> 60 years) presented better scores for total R-HEI, total vegetables and empty calories from solid fats, sugar and alcohol (GORD_AA) (p<0.05). Socioeconomic and lifestyle factors were associated to diet quality in cardiometabolic risk population, indicating the importance of identifying and considering in nutritional education strategies.

Soluble extracts from carioca beans (Phaseolus vulgaris l.) affect the gut microbiota and iron related brush border membrane protein expression in vivo (Gallus gallus)

Desirrê Morais Dias, Nikolai Kolba, Jon J. Hart, Michelle Ma, Sybil T. Sha, Naveena Lakshmanan, Marilia Regini Nutti, Hércia Stampini Duarte Martino, Raymond P. Glahn, Elad Tako
Food Research International, v.123, p. 172-180
Impact factor: 3.086

Abstract: The effect of soluble extracts with putative prebiotic ability extracted from various bean varieties on the intestinal brush border membrane (BBM) iron related proteins, and intestinal bacterial populations were evaluated using the Gallus gallus model and by the intra-amniotic administration procedure. Eight treatment groups [(noninjected; 18MΩ H2O; 40 mg/mL Inulin; 50 mg/mL BRS Perola (carioca standard); 50 mg/mL BRS Cometa (carioca, Fe biofortified); 50 mg/mL BRS Esteio (black, standard); 50 mg/mL SMN 39 (black, Fe biofortified); 50 mg/mL BRS Artico (white, standard)] were utilized. Tested groups reduced the relative abundance of Clostridium and E. coli compared to the Inulin group (positive control) and they did not affect the relative abundance of Bifidobacterium and Lactobacillus compared to the negative control (18MΩ H2O). The relative expression of zinc transporter 1, ferroportin and amino peptidase were up-regulated in the BRS Cometa group (Fe-biofortified carioca beans). Results suggest that soluble extracts from carioca beans may improve the iron bioavailability by affecting intestinal bacterial populations, and BBM functionality

The hidden hunger and fibromyalgia: A systematic review

Rafael Marins Resende, Sylvia do Carmo Castro Franceschini, Antônio José Natali
Revista Chilena de Nutricion, v.46, p. 160-167

Abstract: Recently the possibility of a causal link between fibromyalgia (FM) and micronutrient deficiency , a type of malnutrition known as “hidden hunger”, has been suggested. However, the results are controversial, which raises questions and debates on the actual influence of “hidden hunger” on the development of FM. In this review, we present and discuss scientific evidence related to micronutrient deficiencies and FM, highlighting key micronutrients involved. We searched PubMed and Science Direct databases for all observational studies published between 2000 to March 2017. We selected fourteen observational studies, eight studies aimed at linking vitamin D deficiency to the presence of FM and six studies focused on the association of mineral deficiency with FM. The association between vitamin D deficiency and increased pain sensitivity in FM is suggested, although such insufficiency is also associated with other chronic musculoskeletal disorders. It appears that mineral deficiency (e.g., iron, magnesium, manganese, zinc and calcium) plays an important role in the onset of FM and its main symptoms. Keywords: Fibromyalgia; Hidden hunger; Micronutrient deficiency; Mineral deficiency; Vitamin deficiency.

Thermoregulation in Hypertensive Rats during Exercise: Effects of Physical Training

Luis Henrique Lobo Silame Gomes, Miguel Araújo Carneiro-Júnior, Alessandro Oliveira, Antônio José Natali
Arquivos Brasileiros de Cardiologia, v.112, p 534-542
Impact factor: 1.679

Abstract: Background: Spontaneously hypertensive rats (SHR) show deficit in thermal balance during physical exercise. Objective: To assess the effects of low-intensity physical exercise training on thermal balance of hypertensive rats undergoing an acute exercise protocol. Methods: Sixteen-week-old male Wistar rats and SHR were allocated into four groups: control Wistar rats (C-WIS), trained Wistar (T-WIS), control SHR (C-SHR) and trained SHR (T-SHR). Treadmill exercise training was performed for 12 weeks. Blood pressure, resting heart rate and total exercise time was measured before and after the physical exercise program. After the exercise program, a temperature sensor was implanted in the abdominal cavity, and the animals subjected to an acute exercise protocol, during which core temperature, tail skin temperature and oxygen consumption until fatigue were continuously recorded. Mechanical efficiency (ME), work, heat dissipation threshold and sensitivity were calculated. Statistical significance was set at 5%. Results: Physical training and hypertension had no effect on thermal balance during physical exercise. Compared with C-WIS, the T-WIS group showed higher heat production, which was counterbalanced by higher heat dissipation. Hypertensive rats showed lower ME than normotensive rats, which was not reversed by the physical training. Conclusion: Low-intensity physical training did not affect thermal balance in SHR subjected to acute exercise.

Triglyceride-glucose index is associated with symptomatic coronary artery disease in patients in secondary care

Alessandra da Silva, Ana Paula Silva Caldas, Helen Hermana Miranda Hermsdorff, Josefina Bressan
Cardiovascular Diabetology, v18, p. 1-8
Impact factor: 5.948

Abstract: Background: The triglyceride-glucose index (TyG index) is a tool for insulin resistance evaluation, however, little is known about its association with coronary artery disease (CAD), which is the major cardiovascular death cause, and what factors may be associated with TyG index. Objective: To evaluate the association between the TyG index and the prevalence of CAD phases, as well as cardio‑vascular risk factors. Methods: The baseline data of patients in secondary care in cardiology from Brazilian Cardioprotective Nutritional Program Trial (BALANCE Program Trial) were analyzed. Anthropometric, clinical, socio-demographic and food consumption data were collected by trained professionals. The TyG index was calculated by the formula: Ln (fasting triglycerides (mg/dl)×fasting blood glucose (mg/dl)/2) and regression models were used to evaluate the associations. Results: We evaluated 2330 patients, which the majority was male (58.1%) and elderly (62.1%). The prevalence of symptomatic CAD was 1.16 times higher in patients classifed in the last tertile of the TyG index (9.9±0.5) compared to those in the frst tertile (8.3±0.3). Cardiometabolic risk factors were associated with TyG index, with the highlight for higher carbohydrate and lower lipid consumption in relation to recommendations that reduced the chance of being in the last TyG index tertile. Conclusion: The TyG index was positively associated with a higher prevalence of symptomatic CAD, with metabolic and behavioral risk factors, and could be used as a marker for atherosclerosis.

Waist circumference, waist-to-height ratio and conicity index to evaluate android fat excess in brazilian children

Mariana De Santis Filgueiras, Sarah Aparecida Vieira, Poliana Cristina de Almeida Fonseca, Patrícia Feliciano Pereira, Andréia Queiroz Ribeiro, Silvia Eloiza Priore, Sylvia do Carmo Castro Franceschini, Juliana Farias de Novaes
Public Health Nutrition, v.22, p.140-146
Impact factor: 2.526

Abstract: Objective: To evaluate the ability of anthropometric measurements to identify excess android fat and to propose cut-off points for excess central adiposity in children, according to age and sex. Design: A cross-sectional study with children from a municipality of Minas Gerais, Brazil. Receiver-operating characteristic curve analyses were performed to evaluate waist circumference (WC), waist-to-height ratio (WHtR) and conicity index (C-index) in estimating excess android fat by dual energy X-ray absorptiometry (DXA). Setting: Viçosa, Minas Gerais, Brazil. Subjects: Children aged 4–9 years (n 788). Results: Overweight prevalence was 29·1 % and android fat percentage was higher among girls. All central fat measurements were able to discriminate excess android fat in the age groups evaluated, especially WC and WHtR, with cut-off points showing good sensitivity and specificity overall. Conclusions: Because these methods are easy to obtain and inexpensive, it is possible to use WC, WHtR and C-index in population surveys to evaluate central obesity. The proposed cut-off points showed satisfactory values of sensitivity and specificity and can be used in epidemiological studies.

Waist-to-height ratio and the conicity index are associated to cardiometabolic risk factors in the elderly population

Luana Cupertino Milagres, Karina Oliveira Martinho, Fernanda Silva Franco, Andreia Queiroz Ribeiro, Juliana Farias de Novaes
Ciência e Saúde Coletiva. V,24, p. 1451-1461
Impact factor: 0.780

Abstract The purpose of this study was to determine and compare a magnitude of the association between anthropometric indicators with risk of cardiometabolic risk in the elderly. This is a cross-sectional study with 402 elderly people attended by the Family Health Strategy in the city of Viçosa-MG. Risk factors for excess body fat, hypertension, blood glucose and serum lipid changes. An association between conicity index (CI) and waist-to-height ratio (WtHR) with cardiometabolic risk factors was assessed by multiple linear regression analysis. Sample was composed of 60.4% of women and 36.3% of overweight elderly. The connectivity index and a waist-to-height ratio were higher in 57.2% and 88.1% in the elderly, respectively. The results showed that the increase in body fat, diastolic blood pressure, triglycerides, glycemia and reduction of HDL-cholesterol are related to higher values of anthropometric indices evaluated. However, the waist-to-height ratio presented a greater magnitude of association with the cardiometabolic risk factors than the connectivity index

Whole flour and protein hydrolysate from common beans reduce the inflammation in balb/c mice fed with high fat high cholesterol diet

Samara Leticia Lima, Marian Juste Condim Gomes, Barbara Pereira da Silva, Natalia Elizabeth Galdino Alves, Renata Celi Lopes Toledo, Jaqueline Vieira Piovezana, Maria Eliza de Castro Moreira, Sérgio Luiz Pinto da Mata, Elvira Gonzales de Mejia, Hércia Stampini Duarte Martino
Food Research International, v. 122, p. 330-339
Impact factor: 3.086

Abstract: Common bean (Phaseolus vulgaris L.) is a source of bioactive peptides, but little is known about its effects on hypercholesterolemia, oxidative stress, and the inflammatory process. Therefore, the aim of this study was to evaluate the effect of whole flour and bean protein hydrolysate of common bean variety Carioca on inflammation and oxidative stress in BALB/c mice. Four experimental groups were included in the study: standard diet (SD), high fat high cholesterol diet (HFC), high fat high cholesterol diet and whole bean flour (HFC-F); and high fat high cholesterol diet and bean protein hydrolysate (HFC-PH). Animals fed with bean protein hydrolysate showed lower weight gain and food intake. Animals fed with whole bean flour showed lower alanine aminotransferase and low-density lipoprotein cholesterol levels than animals fed with bean protein hydrolysate. SOD mRNA was lower in HFC, HFC-F and HFC-PH groups whereas SOD concentration was higher in HFC-F and HFC-PH groups. HSP72 mRNA expression was lower in the HFC-F group in relation to HFC-PH. IL-10 and PPARα mRNA expression was lower in HFC-F and HFC-PH groups in comparison with SD. The whole bean flour and bean protein hydrolysate reduced inflammation and the risk factors for cardiovascular diseases in BALB/c mice.

Yacon (Smallanthus sonchifolius)-based product increases fecal short-chain fatty acids and enhances regulatory T cells by downregulating RORγt in the colon of BALB/c mice.

Leticia de Nadai Marcon, Luis Fernando de Sousa Morais, Bruna Cristina dos Santos Cruz, Celia Lucia de Luces Fortes, Maria do Carmo Gouveia Peluzio
Journal of Functional Foods, v.55, p. 333-342
Impact factor: 3.144

Abstract: Although yacon (Smallanthus sonchifolius) is a known source of prebiotics (fructooligosaccharides (FOS) and inulin) and phenolic compounds beneficial to gut microbiota and intestinal immune response modulation, its regulatory mechanisms still remain unclear. Therefore, we investigated whether the consumption of a yacon-based product (PBY) modulates the population of intestinal lymphocytes as well as transcription factors that drive host adaptive immune responses. For this purpose, BALB/c male mice were fed either a standard AIN-93M diet or AIN-93M diet supplemented with PBY (6.0% FOS + Inulin) for 8 weeks. We found that PBY consumption in mice reduced food intake, improved fecal humidity and viscosity, intensified fecal short-chain fatty acid production, increased the number of regulatory T cells, and downregulated the expression of RORγt transcription factor in the colon. Thus, it can be inferred from the findings that PBY consumption improves satiety and mucosal integrity, and possibly favors anti-inflammatory immune responses in the colon.


Secretaria da Pós Graduação em Ciência da Nutrição
Departamento de Nutrição e Saúde / CCBII
Campus Universitário
CEP: 36570-900 Viçosa MG – Brazil
Telephone: + 55 31 3612-5186
FAX: + 55 31 3612-5187

© 2020 Universidade Federal de Viçosa - Todos os Direitos Reservados