Publications of 2018

Blood pressure is associated with body adiposity indicators in children aged 4 to 7 years

Sarah Aparecida Veira, Poliana Cristina de Almeida Fonseca, Cristiane Santos Andreoli, Patrícia Feliciano Pereira, Helen Hermana Miranda Hermsodrff, Andreia Queiroz Ribeiro, Silvia Eloísa Priore, Sylvia do Carmo Castro Fracneschni
Revista Portuguesa de Cardiologia, v.37, n.5, p. 425-432
Impact factor: 1.19

Abstract: Introduction and Objective: Studies in adults have shown an association between increased adiposity and hypertension, but few studies have analyzed this association in childhood. The aim of this study was to investigate the association between blood pressure (BP) and body adiposity indicators in children, controlling for the variables of birth conditions, sociodemographics, lifestyle and diet. Methods: In this cross-sectional study of 399 children aged 4 to 7 years, the dependent variable was BP, measured according to the protocol established by the 7th Brazilian Guidelines on Hypertension. The explanatory variables of the study were waist-to-height ratio (WHtR) and body mass index (BMI). Multiple linear regression was used to assess the independent association between adiposity and BP indicators adjusted for the variables of birth conditions, sociodemographics, lifestyle and diet. Statistical significance was set as =5%. Results: BMI for age and WHtR correlated positively with systolic (SBP) and diastolic blood
pressure (DBP). After multivariate analysis, higher values of BMI (model 1) and WHtR (model 2)
were associated with increased SBP and DBP. Conclusion: Increased body adiposity, as assessed by BMI and WHtR, was associated with increased SBP and DBP among the children studied. Thus, we suggest the use of BMI and WHtR in the nutritional assessment of children to detect changes in BP and other cardiometabolic risk factors in this population.

Acute consumption of yacon shake did not affect glycemic response in euglycemic, normal weight, healthy adults

Daniela Mayumi Usuda Prado Rocha, Priscila Vaz de Melo Ribeiro, Ana Paula Silva Caldas, Bárbara Pereira da Silva, Alessandra da Silva, Alinne Paula de Almeida, Nayara Benedito Martins da Silva, Adriane Moreira Machado, Rita de Cássia Gonçalves Alfenas
Journal of Functional Foods, v. 44, p. 58-64.
Impact factor: 3,144

Abstract: Yacon (Smallanthus sonchifolius (Poepp.) H. Rob) is a natural source of fructooligosaccharides (FOS) studied for its potential as a functional food for prevention and management of chronic diseases, in part associated with its positive impact on glycemic response and body weight. However, yacon beneficial effect on glucose response and food intake control are still controversial. We investigated the acute effect of yacon consumption on glycemic response, subjective appetitive sensations, and food intake in a crossover trial. Fifteen healthy adults consumed 350 mL of yacon (21 g of yacon flour with 7.4 g of FOS) or control shake, on two non-consecutive days (washout). Yacon shake did not affect glycemic response, appetite or food intake. However, it is possible that positive effects of yacon consumption may turn evident only after its chronic consumption. Further studies are needed to assess the long-term effect of yacon consumption on glucose response and body weight control.

Addition of pooled pumpkin seed to mixed meals reduced postprandial glycemia: A randomized placebo-controlled clinical trial.

Flávia G. Cândido, Fernanda C.E. de Oliveira, Mário Flávio C. Lima, Carina A. Pinto, Letícia L. da Silva, Hércia S.D. Martino, Marcelo H. dos Santos, Rita de Cássia G. Alfenas
Nutrition Research, v.2018, p.1-8
Impact factor: 2,727

Abstract: We investigated if pumpkin and flaxseeds could improve postprandial glycemic, food intake, and appetitive responses. Herein, we hypothesize based on the literature that pumpkin seed has potential to lower postprandial glycemic effects. Therefore, we conducted a randomized, singleblind, placebo-controlled, crossover design study involving normoglycemic adults (food intake: n = 25; glycemia: n = 15). Three high-carbohydrate mixed meals presenting no seed (control [C]) or 65 g of the tested seeds (pumpkin seed [P] or flaxseed [F]) were consumed in 3 nonconsecutive days. Test meals had similar nutritional composition. Blood glucose was measured by capillary finger blood at 0 (immediately before), 15, 30, 45, 60, 90, and 120 minutes after the ingestion of each meal, and the incremental area under glycemic response curves (iAUC) were calculated. Appetitive responses were assessed, and dietary records were used to evaluate food intake on testing days. Glucose iAUC was significantly lower in P compared with C (reduction of ~35%, P = .025). There was no significant differences in glucose iAUC between F and C (P = .257). Glycemic response at each time point did not differ between C, P, and F (Pgroup × time = .238). Fiber consumption was higher in F (P = .009) than in C, but there were no differences in appetitive responses, energy, or macronutrient consumptions between dietary interventions. Acute consumption of 65 g of pumpkin seed markedly reduced postprandial glycemia. Pumpkin seed has potential as a hypoglycemic food, which now deserves to be confirmed in long-term studies.

Agreement of body adiposity index (BAI) and paediatric body adiposity index (BAIp) in determining body fat in Brazilian children and adolescents

Mariana De Santis Filgueiras, Roberta Stofeles Cecon, Eliane Rodrigues de Faria, Franciane Rocha de Faria, Patrícia Feliciano Pereira, Andréia Queiroz Ribeiro, Silvia Eloiza Priore and Juliana Farias de Novaes
Public Health Nutrition 22(1), 132–139
Impact factor: 2,326

Abstract: Objective: To evaluate agreement of the body adiposity index (BAI) and paediatric body adiposity index (BAIp) in estimating body fat compared with dual-energy X-ray absorptiometry (DXA) and to propose cut-off points for these indices to classify excess adiposity in Brazilian children and adolescents. Design: Cross-sectional study. Measures of weight, height, hip circumference, BMI and body fat percentage (%BF) assessed by DXA were taken, and BAI and BAIp were calculated. The Bland–Altman plot was used to estimate agreement between the methods, and the receiver-operating characteristic curve to determine the cutoff points for BAI and BAIp per age and sex in comparison with DXA. Setting: Viçosa, Minas Gerais, Brazil. Subjects: Children and adolescents aged 8–19 years (n 1049). Results: Of the children and adolescents, 52·4 % were girls. BAI and BAIp had satisfactory performance by the receiver-operating characteristic curve, except for the 18–19 years age group, whose BAIp had better predictive capacity than BAI. The agreement analysis showed that BAI overestimated %BF by 2·64 %, on average, using DXA; while BAIp underestimated %BF by 3·37 %. Conclusions: BAI and BAIp showed low agreement with the body fat obtained by DXA, requiring caution when interpreting body composition data in children and adolescents.

Analysis of the national school feeding program in the municipality of Viçosa, state of Minas Gerais, MG, Brasil

Naruna Pereira Rocha, Mariana De Santis Filgueiras, Fernanda Martins de Albuquerque, Luana Cupertino Milagres, Ana Paula Pereira Castro, Mariane Alves Silva, Glauce Dias da Costa, Silvia Eloiza Priore, Juliana Farias de Novaes
Revista de Saúde Pública. 2018;52:16

Abstract: OBJECTIVE: To analyze the implementation of the Brazilian National School Feeding Program as a food and nutritional security policy in public schools. METHODS: This a cross-sectional study, with a quantitative and qualitative approach, carried
out with 268 schoolchildren aged eight to nine years from the public school system of Viçosa, state of Minas Gerais, Brazil, in 2015. Interviews were carried out using semi-structured questionnaires with the children, parents, cooks, nutritionists, trainer of the Technical Assistance and Rural Extension Company, and president of the School Feeding Council. In order to analyze the implementation of the National School Feeding Program in Viçosa, we evaluated the direct weighing of the food served in the schools using mechanical balances with a capacity of up to 10 kg and the perception of the social players involved in the implementation of the National School Feeding Program. The children were questioned about the acceptance of and adherence to the food offered, in addition to the habit of bringing food from home. Parents reported knowledge about the School Feeding Program and Council. The qualitative analysis consisted of content analysis and quantitative analysis using the chi-square test, Fisher’s exact test, and Mann-Whitney test. We adopted the statistical significance of 5% for quantitative analysis. RESULTS: Children reported low adherence to the school feeding program and most of them used to bring food from home. Irregularities were identified in the implementation of the National School Feeding Program, such as: inadequate number of nutritionists, suspension of Council meetings, inadequate infrastructure in the areas of preparation and distribution of meals, lack of training of cooks, lack of nutritional adequacy of the food offered, and lack of actions on food and nutritional education. The Program complied with the recommendations for purchasing food from family farms. CONCLUSIONS: The National School Feeding Program presented many irregularities in Viçosa. It is important to monitor the problems identified for better reformulation and planning

Anthropometric patterns of adiposity, hypertension and diabetes mellitus in older adults of Viçosa, Brazil: A population-based study

Fabiane AC Rezende, Andréia Q Ribeiro, Sueli A Mingoti, Patrícia F Pereira, João CB Marins, Silvia E Priore, Sylvia CC Franceschini
Geriatrics & Gerontology International. 2018.
Impact factor: 2,351

Abstract: Aim: To identify anthropometric patterns of adiposity and estimate their association with hypertension and diabetes mellitus (DM) in older adults. Methods: A cross-sectional study with 537 older adults aged ≥60 years was carried out. Weight, height, and waist, hip and calf circumference were measured. The following indices were calculated: a body shape index, body roundness index, conicity index, body adiposity index, body mass index, waist-to-height ratio, waist-to-calf ratio, waist-to- hip ratio and waist-to-hip-to-height ratio. The anthropometric patterns of adiposity were obtained by factor analysis of principal components, and their association with hypertension and DM was identified by multiple Poisson regression with robust variance. Results: Two anthropometric patterns of adiposity were identified. Pattern 1 and 2 explained approximately 53% and 33% of the total variance, respectively, in both sexes. Pattern 1 indicated of global adiposity, and weight, body mass index and hip circumference were the variables most strongly correlated with this pattern in both sexes. Pattern 2 represented the body fat distribution, being a body shape index the most important variable in this factor. After adjustment by confounding factors, only the pattern 2 remained significantly associated with DM in women. Conclusions: Only the anthropometric pattern of adiposity central was associated with DM in older women.

Antioxidant and antimicrobial activities of crude extracts and fractions of cashew 3 (Anacardium occidentale L.), cajui (Anacardium microcarpum) and pequi (Caryocar 4 brasiliense C). A systematic review

Anderson Baptista, Reggiani Gonçalves, Josefina Bressan, Maria do Carmo Gouveia Peluzio
Oxidative Medicine and Cellular Longevity, 2018.
Impact factor: 4,593

Abstract: The accentuated increase in the use of medicinal plants by the population to treat diseases makes it necessary to carry out pharmacological studies in order to contribute to the scientific knowledge and clarify the mechanisms involved in the main compounds present in these plants. Due to the difficulty of combating antimicrobial-resistant microorganisms, plants become a low-cost and effective alternative. The stem, fruit and leaves of plants are used to measure antioxidant and antimicrobial capacity and to combat the oxidative degradation of free radicals produced in the presence of xenobiotics. A systematic review is a powerful tool that incorporates the variability among the studies, providing an overall estimate of the use of plant extracts as antioxidants and antimicrobial activities. In view of the controversies in the literature regarding the use of compounds from plants or the isolation and purification of the main substances for the prevention of bacterial various therapeutic actions, the aim of this was to present a systematic review on the antimicrobial and antioxidant properties of cashew (Anacardium occidentale), cajui (Anacardium microcarpum) and pequi (Caryocar brasiliense). The following databases were analyzed: Pubmed/Medline, Virtual Health library (LILACS and Scielo) and Science Direct. Out of 425 articles, 33 articles have been used in this study, which were also represented in the The Prisma Statement. In vitro antioxidant tests were conducted in 28 studies using different methodologies. Most of the tests involving the studied species demonstrated positive antioxidant potential and antimicrobial properties. The results provide important data and perspectives into the use of natural products that can contribute to the treatment of various diseases.

Association between serum zinc level and hypercholesterolemia and insulin resistance in Brazilian children

Fernanda Martins de Albuquerque, Mariana De Santis Filgueiras, Naruna Pereira Rocha, Ana Paula Pereira Castro, Luana Cupertino Milagres, Milene Cristine Pessoa, Sylvia do Carmo Castro Fransceschini, Juliana Farias de Novaes
Cadernos de Saúde Pública 2018; 34(1):e00175016
Impact factor: 1,113

Abstract: The objective of the study was to assess the association between serum zinc level and cardiometabolic factors in prepubertal Brazilian children. This was a cross-sectional study in a representative sample of schoolchildren 8 to 9 years of age in public and private urban schools in Viçosa, Minas Gerais State, Brazil. Body composition was assessed with dual-energy x-ray absorptiometry. The study measured serum glucose, insulin, total cholesterol, high and low density lipoprotein cholesterol, triglycerides, apolipoproteins A (Apo A) and B, uric acid, leptin, homocysteine, ultrasenstive C-reactive protein, and serum zinc. Arterial pressure was measured with automatic inflation equipment. Zinc deficiency was observed in 1.3% of the children. Girls showed the worst cardiometabolic profile, with higher prevalence of increased android fat, triglycerides, insulin resistance, leptin, zinc, and Apo A. In the first tertile of serum zinc concentration, prevalence of insulin resistance was 96% higher (PR = 1.96; 95%CI: 1.04-3.66) and hypercholesterolemia was 23% lower (PR = 0.77; 95%CI: 0.61-0.96) than in the reference category (grouped 2nd and 3rd tertiles of serum zinc concentration). Despite the low prevalence of zinc deficiency, insulin resistance was more prevalent in children in the lowest third of serum zinc concentration. It is important to prevent cardiometabolic alterations in childhood, especially insulin resistance, with an emphasis on serum zinc level.

Association between demand-control model components and blood pressure in the elsa-brasil study: exploring heterogeneity using quantile regression analyses.

Leidjaira Juvanhol Lopes
Journal of Work Environment & Health, v. 44,p. 1-18.
Impact factor: 4,071

Abstract: Objectives This study aimed to investigate which components of the demand-control model (DCM) are associated with blood pressure (BP) and ascertain whether these associations vary over the BP distribution. Methods We evaluated the baseline date of 11 647 current workers enrolled in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) (2008-2010), a multicenter cohort study of 35-74-year-old civil servants. Job demands, skill discretion and decision authority were measured using the Brazilian version of the Demand-Control-Support Questionnaire. The associations between DCM components and systolic and diastolic BP (SBP and DBP, respectively) were examined by gamma regression, indicated for modelling skewed continuous variables, and quantile regression. Tests were conducted for interaction with gender and use of antihypertensives. Results In the adjusted gamma models, no association was observed between DCM components and BP in the total study population. Among non-users of antihypertensives, high decision authority was marginally associated with an increase of 0.59 mmHg (95% CI 0.00-1.18) in SBP. In the quantile models, this association was found to be significant from quantiles 35-60. Further significant but inconsistent positive associations were observed between decision authority and DBP among users of antihypertensives (quantiles 5 and 10) and between skill discretion and SBP in the total study population (quantile 5). The results did not differ by gender. Conclusions Decision authority associates positively with SBP, but only in the central portion of the SBP distribution and among non-users of antihypertensives. No consistent associations were observed for skill discretion or job demands

Association between dietary total antioxidant capacity and hepatocellular ballooning in nonalcoholic steatohepatitis: a cross-sectional study.

Daiane Gonçalves de Oliveira, Fabiana de Faria Ghetti, Ana Paula Boroni Moreira, Helen Hermana Miranda Hermsdorff, Juliano Machado de Oliveira, Lincoln Eduardo Villela Vieira de Castro Ferreira
European Journal Nutrition, v.2018, p.1-8.
Impact factor: 4,370

Abstract: Purpose Nonalcoholic steatohepatitis (NASH) is characterized by steatosis, lobular inflammation, ballooning, and in some cases, fibrosis, which can progress to cirrhosis and carcinoma. The progression of NASH is closely related to oxidative stress. Dietary intake of antioxidants has been suggested in protection against oxidative damage and related clinical complications. Thus, we evaluated the potential association of dietary total antioxidant capacity (TAC) with disease severity in NASH patients, as well as with anthropometric and body composition markers and biochemical parameters. Methods Thirty-three outpatients with a mean age of 48.4±1.9 years were evaluated. Dietary TAC was estimated from a quantitative food frequency questionnaire. NASH severity, determined by liver biopsy, lifestyle characteristics, occurrence of comorbidities, anthropometry, body composition, and biochemical parameters were assessed. Results NASH patients who had a higher dietary TAC had fewer ballooned hepatocytes compared to those with a lower TAC (p=0.024). The patients with the highest dietary TAC had a reduction of approximately 20% in the risk of having many ballooned hepatocytes (OR 0.791; 95% CI 0.643–0.974; p=0.027). There was no association of steatosis, lobular inflammation, and fibrosis with dietary TAC. The same occurred for lifestyle characteristics, occurrence of comorbidities, anthropometry, body composition, and biochemical parameters. Conclusion Dietary TAC is higher in patients with lower hepatic injury (ballooning), suggesting a possible role of food intake naturally high in its antioxidant capacity in reducing free radical production and, consequently, oxidative stress.

Association between perceived racial discrimination and hypertension: findings from the ELSA-Brasil study.

Patrícia Miranda Mendes, Aline Araújo Nobre, Rosane Härter Griep, Joanna Miguez Nery Guimarães, Leidjaira Lopes Juvanhol, Sandhi Maria Barreto, Alexandre Pereira, Dóra Chor
Caderno de Saúde Pública, v. 34, p. 1-12
Impact factor: 1,133

Abstract: “Pardos” and blacks in Brazil and blacks in the USA are at greater risk of developing arterial hypertension than whites, and the causes of this inequality are still little understood. Psychosocial and contextual factors, including racial discrimination, are indicated as conditions associated with this inequality. The aim of this study was to identify the association between perceived racial discrimination and hypertension. The study evaluated 14,012 workers from the ELSA-Brazil baseline population. Perceived discrimination was measured by the Lifetime Major Events Scale, adapted to Portuguese. Classification by race/color followed the categories proposed by Brazilian Institute of Geography and Statistics (IBGE). Hypertension was defined by standard criteria. The association between the compound variable – race/racial discrimination – and hypertension was estimated by Poisson regression with robust variance and stratified by the categories of body mass index (BMI) and sex. Choosing white women as the reference group, in the BMI < 25kg/ m2 stratum, “pardo” women showed adjusted OR for arterial hypertension of 1.98 (95%CI: 1.17-3.36) and 1.3 (95%CI: 1.13-1.65), respectively, whether or not they experienced racial discrimination. For black women, ORs were 1.9 (95%CI: 1.42-2.62) and 1.72 (95%CI: 1.36-2.18), respectively, for the same categories. Among women with BMI > 25kg/m2 and men in any BMI category, no effect of racial discrimination was identified. Despite the differences in point estimates of prevalence of hypertension between “pardo” women who reported and those who did not report discrimination, our results are insufficient to assert that an association exists between racial discrimination and hypertension.

Association of exclusive breastfeeding duration with consumption of ultra-processed foods, fruit and vegetables in brazilian children

Poliana Cristina de Almeida Fonseca, Sarah Aparecida Vieira Ribeiro2, Cristiana Santos Andreoli, Carolina Abreu de Carvalho, Milene Cristine Pessoa, Juliana Farias de Novaes, Silvia Eloisa Priore6 e Sylvia do Carmo Castro Franceschini
European Journal of Nutrition 2018, p.1-8
Impact factor: 4,370

Abstract: Background There has been little evidence of the influence of breastfeeding on childhood eating habits. Aim To evaluate the association between duration of exclusive breastfeeding (EB) and consumption of ultra-processed foods, fruits and vegetables by Brazilian children. Methods This is a cross-sectional study nested in a cohort of 403 children age 4–7 years. Food consumption was evaluated by three food records and the foods were grouped by the amount of processing involved (minimal, including fruit and vegetables to ultra-processed foods). Adjusted linear and multinomial regression models were proposed to evaluate the association of EB with children’s food intake. Median duration of EB was 4.0 (2.0–6.0) months and the prevalence of EB of 4 months or more was 60.9%. Results Mean energy consumption was 1536 kcal/day, 38% of energy was from ultra-processed foods. Mean intake of fruit and vegetables was 130 g/day. For each 1-month increase in duration of EB there was a 0.7% decrease in energy from ultraprocessed foods (β: −0.7; 95% CI: −1.3 to 0.1; p=0.038). EB of less than 4 months was associated with the child being in the lowest tercile for consumption of fruit and vegetables (Adjusted OR: 1.8; 95% CI: 1.1–3.0; p=0.030) and the highest for consumption of ultra-processed foods (adjusted OR: 1.7; 95% CI: 1.1–2.9; p=0.040). Conclusions In addition to other benefits of EB, we emphasize its importance for the formation of healthy eating habits, contributing to a higher consumption of fruit and vegetables and lower consumption of ultra-processed foods in childhood.

Bacupari peel extracts ( GARCINIA BRASILIENSIS ) Reduces the biometry, lipogenesis and hepatic steatosis in obese rats.

Maria Eliza de Castro Moreira, Fernanda de Oliveira Araújo, Andressa Rodrigues de Sousa, Renata Celi Lopes Toledo, Laércio dos Anjos Benjamin, Marcia Paranho Veloso, Kassius de Souza Reis, Marcelo Henrique dos Santos, Hercia Stampini Duarte Martino
Food Research International, v.114, p 169-177
Impact factor: 3,086

Abstract: The aim was to evaluate the effect of the ethanol extract of bacupari peel (EEB) on biometric measurements, hepatic lipogenesis and progression of non-alcoholic fatty liver disease (NAFLD) in obese Wistar rats. Chemical analysis of the bacupari peel extract identified 7-epiclusianone as the major constituent (140.02 mg/g) followed by morelloflavone (35.86 mg/g). Animals treated with high fat diet plus EEB (BHFD) reduced body mass index (BMI), liver weight and hepatosomatic index in relation to the obese control. The food intake was similar between hyperlipid group (HFD) groups with or without EEB. However, the normal control group (AIN-93 M) presented higher food intake and lower final weight compared to the obese control (HFD). The PPAR-α, CPT-1a and the ADIPOR2 genes expressions, and the concentration of the PPAR-α and the adiponectin protein level increased in the BHFD group in relation to the obese control. The EEB promoted reduction of the SREBP-1c gene expression and the percentage of hepatic fat and the degree of steatosis in relation to HFD. It was concluded that EEB showed a protective effect on NAFLD, as it promoted a reduction in BMI, induced lipid oxidation, reduced lipogenesis and hepatic steatosis. Moreover, our results suggest an interaction that can lead to an agonist activity of the EEB to the PPAR-α receptor.

Baseline pro-inflammatory diet is inversely associated with change in weight and body fat 6 months following-up to bariatric surgery.

Patrícia Amaro Andrade, Helen Hermana M. Hermsdorff, Jacqueline Isaura Alvarez Leite, Nitin Shivappa, James R. Hébert, Hirla Karen Fialho Henriques e Carla de Oliveira Barbosa Rosa
Obesity surgery, v. 2018, p.1-7
Impact factor: 3,947

Abstract: Objective To evaluate whether the baseline Dietary Inflammatory Index (DII®) was associated with weight loss and body composition change after bariatric surgery. Methodology This longitudinal study included 132 women with obesity (BMI ≥ 35 kg/m2 , 43.0 ± 9.7 years), followed up for 6 months after bariatric surgery. The DII® was calculated from dietary data collected using 24-h dietary recall interviews. Anthropometric variables, socio demographic variables, health-related habits, history of disease, as well as gastrointestinal symptoms, both in the preoperative period (baseline) and 6 months after bariatric surgery were collected from the patients’ medical records. Results Individuals with a more pro-inflammatory diet (DII > 0.35 median value) preoperatively experienced smaller weight loss (− 22.7% vs. − 25.3%, p = 0.02) and fat mass loss (− 31.9 vs. − 36.2%, p = 0.026), with no difference in lean mass (p = 0.14). In a linear regression model, the baseline DII score was negatively associated with percentage change in weight and fat mass and positively associated with weight and fat mass in the sixth month after surgery. In addition, a pro-inflammatory baseline DII score was correlated with a lower intake of fruit (r = − 0.26, p = 0.006), vegetables (r = − 0.47, p = 0.001), and legumes (r = − 0.21, p = 0.003) in the postoperative period. Conclusion In this longitudinal study, a pro-inflammatory diet at baseline was associated with smaller reductions in weight and body fat and poorer dietary quality (reduced consumption of fruits, vegetables, and legumes) 6 months after bariatric surgery.

Behavioral patterns that increase or decrease risk of abdominal adiposity in adults

Danielle Cristina Guimarães da Silva, Kelly Aparecida da Cunha, Wellington Segheto, Vanessa Guimarães Reis, France Araújo Coelho, Sílvia Helena O. Morais, Milene Cristine Pessoa and Giana Zarbato Longo
Nutricion Hospitalaria, v. 35, p.90-97
Impact factor: 0,747

Abstract: Introduction: The identification of risk or protective behavioral patterns associated with abdominal adiposity may aid in prevention and health promotion measures. Objective: To identify and to associate behavioral patterns of risk and protection to abdominal adiposity in adults in a Brazilian city. Material and methods: A population-based cross-sectional study was carried out in Viçosa, Brazil, with 1,226 adults of both sexes. Information on social-demographic characteristics, food intake, level of physical activity, alcohol consumption and smoking were collected by using a questionnaire. The anthropometric measurement of waist circumference and anthropometric indices waist/hip ratio and waist/height ratio were indicators of abdominal adiposity. To identify behavioral patterns, exploratory factor analysis was applied for the variables considered as risk or protective factors. The association of the identified patterns with abdominal adiposity was estimated by multiple linear regression, adjusted for gender, age and social economical class. Results: Two patterns were obtained, “healthy” and “risk”. The “healthy” pattern, comprised of the clustering of the variables food consumption, fruits, fresh fruit juices, raw and cooked vegetables and the appropriate level of physical activity, was negatively associated with abdominal adiposity identified by waist circumference (p = 0.048), waist/hip (p = 0.013) and waist/height (p = 0.018) indices. The “risk” pattern, composed of smoking, alcohol beverage abuse and habit of consuming visible fat in fat-rich red meat or poultry skin, was positively associated with abdominal adiposity identified by waist circumference (p = 0.002) and waist/hip (p = 0.007) and waist/height indices (p = 0.006). Conclusions: Two behavioral patterns were identified, a risk pattern and a protective pattern for abdominal adiposity in the assessed population. The study shows the importance of conducting clustering of multiple risk and protective factors to better explain the health conditions of a group.

Body dissatisfaction, physical activity, and sedentary behavior in female adolescents

Valter Paulo Neves Miranda, Núbia Sousa de Morais, Eliane Rodrigues de Faria, Paulo Roberto dos Santos Amorim, João Carlos Bouzas Marins, Sylvia do Carmo Castro Franceschini, Paula Costa Teixeira, Silvia Eloiza Priore
Revista Paulista de Pediatria, v. 2018, p.1-9
Impact factor

Abstract: Objective: To evaluate the association of body image with physical activity level, body composition, and sedentary behavior (SB) of female adolescents. Methods: Exploratory cross‑sectional study conducted with 120 female adolescents aged between 14‑19 years, from the city of Viçosa, Minas Gerais, Southeast Brazil. Body image was evaluated with a Body Silhouette Scale (BSS) and a Body Shape Questionnaire (BSQ). Weight, height, and waist circumference values were analyzed, as well as the waist‑to‑height ratio and body fat percentage. The physical activity level (PAL) was assessed by 24‑hour Physical Activity Recall and SB by screen time, that is, time spent in front of a TV, playing video game, on the computer and using tablets, and, separately, the cell phone time. Results: Mean age was 16.5±1.5 years, and most adolescents were eutrophic (77.6%), sedentary/low PAL (84.2%), with high screen time (85.2%) and cell phone time (58.7%). Body dissatisfaction was stated in 40.6% of BSQ and 45.8% of BSS evaluations. Body distortion was identified in 52.9% of participants. All body composition measures, along with cell phone time and PAL, were associated with body dissatisfaction, the more active adolescents presenting higher levels of dissatisfaction. Conclusions: This study concluded that female adolescents with higher cell phone time also present higher body dissatisfaction, as well as the most physically active ones. All body composition measurements were associated with body dissatisfaction, mainly body mass index, waist circumference, and waist‑to‑height ratio

Body image of female adolescents and its association with body composition and sedentary behavior

Núbia de Souza de Morais, Valter Paulo Neves Miranda e Silvia Eloiza Priore
Ciência & Saúde Coletiva, 23(8):2693-2703, 2018
Impact factor: 0,780

Abstract: The scope of this article is to evaluate the body image and its association with body composition, anthropometric indicators and sedentary behavior of female adolescents. It involved a cross-sectional study with female adolescents from Viçosa in the state of Minas Gerais. The body image was assessed by the Body Shape Questionnaire (BSQ) and by the Silhouette Scale. The body fat percentage (BFP) and other anthropometric parameters were measured. The sedentary behavior (SB) was evaluated by the sum of screen time (ST) and cellular time (CT). The sample consisted of 274 adolescents, the majority having an adequate BMI (81.6%), however, 53.9% had elevated BFP. More than half of the adolescents had elevated SB, 68.2% with ST and 54.7% with CT above 2h. Body dissatisfaction was expressed as 45.7% by BSQ and 50.2% wished for a silhouette different than the current silhouette. The waist circumference (WC) (OR = 11.94, CI = 2.744 – 51.728) and waist-to-height ratio (WHR) (OR = 10.535, CI = 3.109 – 35.698) were the measurements most associated with body dissatisfaction. All body composition measurements were significantly associated with body dissatisfaction, and the WC and WHR the most conditioning factors with dissatisfaction. The SB was elevated; however, it was not associated with a negative assessment of body image.

Buriti of the cerrado of minas gerais, Brazil: physical and chemical characterization and content of carotenoids and vitamins

Fabiana Rossini HAMACEK, Ceres Mattos DELLA LUCIA, Bárbara Pereira da SILVA, Ana Vládia Bandeira MOREIRA, Helena Maria PINHEIRO-SANT’ANA
Food Science and Technology, 2018, p.1-7
Impact factor: 0,833

Abstract: The fruit species of the Brazilian Cerrado, such as buriti (Mauritia vinifera), occupy a prominent position in the ecosystem since they contribute to the economic potential of the region and have high nutritional value. We aimed to evaluate the physical characteristics, chemical composition and content of vitamin C, carotenoids, vitamin E and folates in pulp of buriti from the Brazilian Cerrado of Minas Gerais, Brazil. The length, diameter, mass and fruit yield were evaluated. The titratable acidity was determined by volumetric neutralization; pH by potentiometry; soluble solids by refractometry; moisture using an oven; ash using a muffle furnace; proteins by the micro-Kjeldhal method; total dietary fiber by the gravimetric non-enzymatic method and lipids with a Soxhlet extractor. Vitamin C and carotenoids were analyzed by high performance liquid chromatography with detection by diode array (HPLC-DAD) and vitamin E and folates by HPLC with fluorescence detection. Buriti pulp showed 12.13 g.100g-1 of lipids and 74.86 g.100g-1 of moisture. Also, the fruit showed high content of dietary fiber, carotenoids, vitamin C, vitamin E and folates. Buriti can contribute to the adequate intake of fiber and vitamins and to preventing the incidence of disorders, especially those more frequent in native populations of the Cerrado.

Carotenoids in the pulp and peel of bananas from 15 cultivars in two ripening stage

César Fernandes Aquino, Luiz Carlos Chamhum Salomão, Helena Maria Pinheiro-Sant’ana, Sônia Machado Rocha Ribeiro, Dalmo Lopes De Siqueira, Paulo Roberto Cecon
Revista Ceres, v.65, n.3, p. 217-226
Impact factor

Abstract: The current study aims to evaluate the occurrence and concentration of carotenoids in the pulp and peel of 14 banana and one plantain cultivars in two ripening stages. We analyzed the occurrence and content of lutein, α- carotene, β-carotene, β-cryptoxanthin, and lycopene – by high performance liquid chromatography with UV-visible detection, the content of total carotenoids by spectrophotometry. In the unripe pulp, the ‘Ouro’ cultivar stood out with lutein concentration 13 times higher than that of the ‘Marmelo’. As for á-carotene and β-carotene, ‘Terrinha’ plantain stood out with mean concentration of 1195.30 and 1126.11 µg (100 g MF-1), respectively. Total carotenoids ranged from 159.66 to 2553.51 µg (100 g MF-1) in ‘Caipira’ and ‘Terrinha’, respectively. In the ripe pulp there was 36% increase in the lutein content in comparison to the unripe pulp and there was 7.3 and 8.5% reduction in α-carotene and β-carotene levels, respectively. The total carotenoid concentration in the ripe pulp was 17% higher than that found in the unripe pulp. The unripe peel showed lutein predominance, although ‘Terrinha’ stood out with higher α-carotene and µ- carotene concentrations than those found in the other cultivars. Lutein concentration hardly changed due to fruit ripening; however, there was slight reduction in α-carotene and β-carotene concentrations.

Chemical composition, carotenoids, vitamins and minerals in wild mustard collected in native areas

Galdino Xavier Paula Filho; Tibério F Barreira; Ricardo HS Santos; Silvia Eloiza Priore; Ceres Mattos Della Lucia; Helena Maria Pinheiro-Sant’Ana
Horticultura Brasileira, v.36, n.1, January – April 2018
Impact factor

Abstract: Wild mustard plant (Sinapis arvensis), Brassicaceae, is a wild vegetable found in forest area, domestic orchards and it is consumed by rural population. This study aimed to study chemical composition (moisture, total dietary fiber, lipids, proteins, ash, carbohydrates and total energetic value), concentration of carotenoids, vitamins (C and E) and minerals (K, Ca, Mg, Cu, Fe, Zn, Mn, Na, Cr, Se and Mo) and the contribution by this vegetable to the recommendations of daily consumption of nutrients for adult individuals. Concentrations of provitamin A (252.21 RAE μg/100 g), Se (0.04 mg/100 g) and Fe (5.91 mg/100 g) stood out, in which this vegetable was considered as an excellent source for these nutrients. In addition, wild mustard was considered a good source of K (435.65 mg/100 g), Ca (123.25 mg/100 g) and Mn (0.40 mg/100 g) and source of Total Dietary Fiber (TDF) (3.20 mg/100 g), Mg (26.82 mg/100 g) and Cu (0.07 mg/100 g). Wild mustard stood out as source, good source or excellent source of the evaluated nutrients, and they may contribute to reduce nutritional deficiency of those nutrients in the populations living in the region where this vegetable occurs.

Clinical-nutrition indicators and inflammatory and oxidative stress markers in morbidity and hemodialysis mortality: an integrative review

Andreza de Paula Santos Epifânio, Karla Pereira Balbino, Sônia Machado Rocha Ribeiro, Sylvia do Castro Franceschini and Helen Hermana Miranda Hermsdorff
Nutricion Hospitalaria, v. 35, p. 461-468
Impact factor: 0,747

Abstract:The evaluation of clinical-nutrition status is essential to increase life quality and improve clinical outcomes of patients in hemodialysis (HD). In the absence of a gold standard, the goal of this integrative review was to present and discuss the latest scientific literature on the ability of clinical-nutritional indicators and inflammatory and oxidative stress markers to predict morbidity and mortality in HD. In this context, the lean and fat mass indexes have become good predictors of mortality in HD individuals, regardless of BMI. Subjective scoring systems have been more sensitive to malnutrition, and altogether anthropometric indicators may result in an early detection of mortality risk in this population. On the other hand, inflammation in HD, as assessed by C-reactive protein, is not only related to cardiometabolic alterations, but it is also one of the key-points in the development of malnutrition, exacerbated by the state of oxidative stress, which has been identified in this group by the increase of the serum levels of gamma-glutamyl transferase and malondialdehyde.

Cohort profile: the cohort of universities of minas gerais (CUME)

Ana Luiza Gomes Domingos, Aline Elizabeth da Silva Miranda, Adriano Marçal Pimenta, Helen Hermana Miranda Hermsdorff, Fernando Luiz Pereira de Oliveira, Luana Caroline dos Santos, Aline Cristine Souza Lopes, Miguel Angel Martinez Gonzalez and Josefina Bressan
International Journal of Epidemiology, v.2018, p.1-10
Impact factor: 7,738

Abstract: CUME is an open concurrent cohort restricted to a high educational-level population group. Initiated in 2016, CUME reached graduates in all Brazilian states and the Federal District. A total of 4291 alumni were eligible for the baseline data collection, mostly women (68%), young adults (72%, 20-39 years old) and postgraduate degree holders (80%). The cohort consists of waves of evaluation that will occur every 2 years in a virtual environment. Among the participants, 40.8% reported being overweight, 22.6% had high total cholesterol, 11.6% had hypertension and 3.3% had type 2 diabetes; all of these frequencies were lower compared with the general Brazilian adult population. However, CUME baseline participants already have chronic diseases, although they are younger and have a higher educational level than the general population, demonstrating the importance of the epidemiological scenario of these groups of diseases in Brazil. The prevalence of depression (12.8%) in our study was two times higher than the national prevalence (5.8%), which could be related to the contemporary lifestyle of our participants marked by an exhausting work routine, physical inactivity, binge drinking and unhealthy eating habits (e.g. saturated fat intake), despite their greater access to information and health services

Collective portfolio: Assessment of teaching and learning in health undergraduate courses

Glauce Dias da Costa, Erik Driessen, Luciana Saraiva da Silva, Aline Aparecida de Oliveira Campos, Thiago de Melo Teixeira da Costa, Cíntia Pereira Donateli, Rosângela Minardi Mitre Cotta
Ciência e Saúde coletiva, v.23, p. 3779-3787
Impact factor: 0,780

Abstract: The potential of the reflective collective portfolio as a method of teaching, learning and assessment needs to be emphasized. The objectives is to assess and validate the quality of the collective portfolio as a method of teaching, learning and assessment in the training of health professional. Portfolio quality was analyzed using an inventory of analysis that was adapted and tested for this study. In total, 70 portfolios were analyzed. The Kappa test was used to analyze reproducibility, confirming the level of agreement between the ap-praisers. Descriptive analysis and the t-test were performed to compare results from the years the portfolios were produced. The constructs (layout and organization, comprehensive, reflective, critical and creative thought) exhibited Cronbach alpha values above 0.7, confirming the high reliability of the tool. The weighted Kappa test revealed an elevated and significant agreement (+90%) between the appraisers. Notably, certain items and constructs exhibited significant differences over the years. All of the constructs were assessed better from 2011 onwards, when the assessment and self-assessment tool was implemented. The success of the portfolio depends on strategies that provide students with greater clarity and forms of developing the method.

Comparative analysis between anthropometry and subjective methods in nutritional evaluation in cancer: a systematic rewiew

Thalita Alves de Barros, Nélia Pinheiro Mendes, Solange Silveira Pereira, Carla de Oliveira Barbosa Rosa, Sylvia do Carmo Castro Franceschini
Journal of Food and Nutrition Research, v.6, p. 570-575
Impact factor: 1,950

Abstract: This study aims to evaluate the anthropometric indicators used in cancer patients, comparing them with one another and with the subjective methods of nutritional assessment. Methodology: A search was made in January 2018 in the databases Medline (PubMed), Latin American and Caribbean Literature in Health Sciences (Lilacs) and Scientific Electronic Library Online (Scielo), with the descriptors oncology, cancer, evaluation, anthropometry, adults, elderly and malnutrition. Results: A total of 10 articles were included in this review. All of them used body mass index (BMI) to diagnose malnutrition; however, fewer malnourished individuals were identified by this method. In addition to BMI, the most used anthropometric indicators were arm muscle circumference, tricipital skinfold and arm perimeter, used in most articles, being the most malnourished identified by it. As for subjective methods, fewer malnourished patients were tracked when compared to perimeters and folds. Conclusion: It is concluded that the arm perimeter is the most anthropometric indicator use in tracking of malnutrition in cancer patients, considering the prevalence

Conditioning factors for exclusive breastfeeding from the mother’s perspective

Gabriele Pereira Rocha, Maria do Carmo Fontes Oliveira, Luciana Beatriz Bastos Ávila, Giana Zarbato Longo, Rosângela Minardi Mitre Cotta, Raquel Maria Amaral Araújo
Cadernos de Saúde Pública, v. 34, p.1-13
Impact factor 1,133

Abstract: The study aimed to explore the positive and negative experiences of mothers with exclusive breastfeeding. A descriptive, qualitative study enrolled 18 breastfeeding mothers of infants (≤ 1 year) recruited in the Municipal Immunization Service in Viçosa, Minas Gerais State, Brazil. Data were obtained from taped, transcribed interviews and submitted to content analysis to verify the thematic units related to positive and negative experiences, after which two texts were drafted, one for each situation. These texts were submitted to similarity analysis with the IRAMUTEQ software, generating two similarity trees. Interpretation of the similarity trees used concordance lines produced by the AntConc software. The principal negative breastfeeding experiences were the infant’s constant demand for the breast, the impossibility of leaving the infant alone, painful breasts, and insecurity concerning the capacity to produce enough milk. The main positive experiences were the biological benefits of breastmilk, practicality, and lower cost. The study allowed grasping the positive and negative dimensions of exclusive breastfeeding and suggests the importance of professional assistance for the woman in the initial phase of breastfeeding, plus social network support to mitigate the woman’s overburdened feeling.

Consumption of virgin coconut oil in wistar rats increases saturated fatty acids in the liver and adipose tissue, as well as adipose tissue inflammation

Mariana de Moura e Dias, Nathane Pais Siqueira, Lisiane Lopes da Conceição, Sandra Aparecida dos Reis, Flávia Xavier Valente, Manoela Maciel dos Santos Dias, Carla de Oliveira Barbosa Rosa, Sérgio Oliveira de Paula, Sérgio Luís Pinto da Matta, Leandro Licursi de Oliveira, Josefina Bressan, Maria do Carmo Gouveia Peluzio
Journal of Functional Food, v.48, p. 472-480
Impact factor: 3,144

Abstract: The recommended amount of intake of virgin coconut oil (VCO) for health benefits has not been defined. This study aims to evaluate the effects of partial dietary substitution of lipid source by VCO in the health of Wistar rats. The animals were divided as: G1, 100% of soybean oil; G2, 10.4% of VCO; G3, 50% of VCO; and G4, 95% of VCO. Weight and body measurements were not affected by substitution, as well as morphometry of adipocytes, food intake and hepatic expression of PPAR-α and CPT-1 genes. VCO consumption affected the serum lipid profile in a dose-dependent way, just like the tissue incorporation of saturated fatty acids, the inflammation in adipose tissue, and the antioxidant and antimicrobial effects. Since, it was not possible to establish the best dose of VCO to be consumed, the current recommendations for the consumption of satured fatty acids should be followed.

Contribution of the production for self-consumption to food availability and food security in households of the rural area of a Brazilian city.pdf

Luiza Veloso Dutra, Dayane de Castro Morais, Ricardo Henrique Silva Santos, Sylvia do Carmo Castro Franceschini e Silvia Eloiza Priore
Ecology of food and nutrition v. 2018, p.1-19
Impact factor: 0,922

Abstract: Production for self-consumption can meet the principles of food safety such as respect for food habits and diversity. The participation of production for self-consumption in food availability was compared to the purchase of food for 30 days in 79 households (272 inhabitants) of the rural area of a Brazilian city in 2012. The food security was evaluated by the method “Food energy deficiency in the domicile” that classified 12.7% of the households as insecure. In all households, staple foods (rice, pasta, corn, beans, milk, eggs, meats) were available and more than 60% had processed foods (cookies, soft drinks). Only 22.7% of the calories came from production for own consumption and the biggest expense was the purchase of carbohydrates (91.1%), mainly sugar (12.2%). Evaluating only the energy availability of food is not sufficient since the quality and origin of food is of great relevance in the food security condition.

Cranberry antioxidant power on oxidative stress, inflammation, and mitochondrial damage

Ana Paula Silva Caldas, Olivia Gonçalves Leão Coelho e Josefina Bressan
International Journal of Food Properties, v. 21, p. 582-592
Impact factor: 1,427

Abstract: The American cranberry (Vaccinium macrocarpon) is one of the fruits containing antioxidants in great quantity and of high quality. From recent research, it is evident that both cranberry and its products, when consumed chronically or acutely, boost the antioxidant effect. Likewise, most studies revealed the antiinflammatory potential of the cranberry polyphenols. Both effects exert direct action mechanisms, revealed by the ability of the polyphenols to remove the reactive oxygen species, as well as indirect effects, represented by the action of these phytochemicals on the cell signaling pathways and genetic expression. A limited number of articles that evaluated the effects of cranberry on mitochondrial damages are available. However, an enhancement in the functions of this organelle was confirmed by the increased production of adenosine triphosphate (ATP). Therefore, further studies are required to demonstrate the benefits credited to the use of cranberry, as well as to describe the action mechanisms of the polyphenols.

Dietary fat and gut microbiota: mechanisms involved in obesity control

Olívia Gonçalves Leão Coelho, Flávia Galvão Cândido e Rita de Cássia Gonçalves Alfenas
Critical Reviews Food Sceince and Nutrition, v. 2018, p.1-9
Impact factor: 6,077

Abstract: Obesity is a serious global health problem that is directly related to various orbidities manifestation. Intestinal dysbiosis has been implicated on obesity pathogenesis. Diet composition can alter gut microbiota, regardless of energy intake. Dietary fatty acids quality may affect gut microbiota composition, which in turn may affect host metabolic health. The mechanisms by which the different type of FFA modulate gut microbiota is yet poor elucidate and there is a lack of studies regard to this. Fatty acids may act in cell membrane, interfere with energy production, inhibit enzymatic activities, impair nutrient absorption and generate toxic compounds to cells, leading to growth inhibition or even bacterial death. The beneficial effect of the consumption of n-3 polyunsaturated fatty acids (PUFA) and conjugated linoleic acid (CLA) on microbiota, unlike n-6 PUFA and saturated fatty acids has been suggested. n-3 PUFA consumption promotes desirable changes on obese intestinal microbiota making it similar to that of normal weight individuals. More studies are needed to better understand the effect of CLA on microbiota and host health. Long term human controlled clinical trials must be conducted to allow us to understand the complex interaction between dietary fat, intestinal microbiota and obesity.

Dietary fat and gut microbiota: mechanisms involved in obesity control

Brenda Kelly Souza Silveira, Thatianne Moreira Silva Oliveira, Patrícia Amaro Andrade, Helen Hermana Miranda Hermsdorff, Carla de Oliveira Barbosa Rosa, and Sylvia do Carmo Castro Franceschini
Cardiology Research and Practice, Volume 2018
Impact factor

Abstract: It is known that the dietary pattern and macronutrients profile may influence the expression and secretion of inflammatory biomarkers, and the low-grade inflammation is associated with the manifestation of noncommunicable chronic diseases. Therefore, this review aimed to present and discuss the role of dietary patterns and macronutrients on the variation of inflammatory markers related to NCD risk. Scientific evidences within the last five years based on clinical trials, case-controls, cohorts, and cross-sectional studies indicate that normocaloric, carbohydrate-moderated, low-glycemic index, protein- moderated, monounsaturated and polyunsaturated fatty acid-rich, omega-3, and low-saturated fat diets display positive effects on the inflammatory state, both in healthy individuals and in those with cardiovascular risk, although the second group seems to benefit more from changes in the dietary profile.

Dysbiosis and metabolic endotoxemia induced by high-fat diet

Thalita Lin Netto Cândido, Josefina Bressan e Rita de Cássia Gonçalves Alfenas
Nutrición Hospitalaria, v.35, p. 1257-1265
Impact factor: 0,742

Abstract: Introduction: diet plays a decisive role in the prevention and treatment of diseases such as obesity, diabetes, allergies and inflammatory diseases. In addition to this, there are numerous investigations about the role of the microbiota in the genesis of metabolic diseases, especially obesity and its comorbidities. Objective: the aim of this review is to discuss the influence of high-fat diets on dysbiosis and metabolic endotoxemia. Results and conclusion: the intestinal microbial ecosystem has been shown to be essential in the performance of functions in the host organism, however, several factors can lead to an imbalance in the homeostasis of the microbiota, known as dysbiosis. High-fat diets are associated with a reduction in intestinal bacterial diversity, changes in membrane integrity, inducing increased permeability and increased lipopolysaccharide (LPS) translocation, changes in the immune system, and generation of low-intensity systemic inflammation. The installed endotoxemia can be considered as a causal factor of subclinical inflammation related to several chronic diseases, and as a result of this, it is essential to know the real impact of hyperlipidic diets on the intestinal microbiota. Thus, it becomes essential to identify dietary strategies that can minimize the inflammatory effects generated from changes in the intestinal microbiota

Eating habits of bereaved individuals: a protocol proposal

Maria Teresa Fialho de Sousa CAMPOS, Maria do Carmo Gouveia PELUZIO e Raquel Maria Amaral ARAÚJO
Revista de Nutrição, v.31, p. 325-337

Abstract: Objective: The objective of this manuscript was to discuss the care inherent to the methodological procedures for food research in bereavement situations, proposing the use of a conduct protocol. Methods:The protocol for food research in bereavement is presented, based on the critical review of literature and the experience with food surveys applied to bereaved people.Results: The conduct protocol is divided into three moments corresponding to the meetings and the steps of approach
are discussed in these care services. This research seeks to problematize this investigation, outlining the phases of coping with bereavement that involve greater adherence, from these individuals, to food surveys. Conclusion: The conduct protocol guiding the investigation of eating habits of bereaved individuals provides information that allows the professional to evaluate the infl uence of bereavement on food in addition to allowing a greater adherence of these individuals to the survey.

Effect of exercise on concentrationsof irisin in overweight individuals: A systematic review

P. Amaro Andrade, B.K. Souza Silveira, A. Corrêa Rodrigues, F.M. Oliveira da Silva, Carla O. Barbosa Rosa, Rita de Cássia Gonçalves Alfenas
Science & Sports, 2018
Impact factor: 0,516

Abstract: Introduction. — Irisin myokine whose secretion is induced by exercise is associated with anincrease in thermogenesis. However, the effect of acute and chronic exercise on the productionand release of irisin in overweight individuals is controversial.Objective. — To evaluate whether acute and chronic exercise affects irisin concentrations inoverweight individuals.Methods. — The Medline/PubMed and Science Direct databases were used. The data searchincluded clinical trials with humans that assessed the effect of acute or chronic exercise onirisin concentrations in overweight or obese individuals. The search terms used were: ‘‘irisin’’AND ‘‘exercise’’ OR ‘‘acute exercise’’ OR chronic exercise ‘‘OR’’ endurance exercise ‘‘OR’’aerobic exercise ‘‘OR’’ strength exercise ‘‘OR’’ resistance exercise ‘‘OR’’ obesity’’.Results. — Nine articles performed in healthy and diabetic subjects were found. The irisin con-centrations in individuals with excess weight increased with acute exercise and remained thesame with chronic exercise. The maximum concentration of irisin occurred between 1 and2 hours after the exercise was completed. The protocols of resistance and high-intensity trainingwere more effective.

Effect of increased calcium consumption from fat-free milk in an energy-restricted diet on the metabolic syndrome and cardiometabolic outcomes in adults with type 2 diabetes mellitus: a randomised cross-over clinical trial

Junia M. G. Gomes, Jorge A. Costa and Rita C. G. Alfenas
British Journal of Nutrition, v. 119, p. 422-430.
Impact factor: 3,706

Abstract: We investigated the effects of high-Ca fat-free milk phase (MD) (prescription of approximately 1500 mg of Ca/d) v. low-Ca phase (CD) (prescription of approximately 800 mg of Ca/d) in an energy-restricted diet on the metabolic syndrome (MetS) and cardiometabolic measures in individuals with type 2 diabetes mellitus (T2DM) and low habitual Ca consumption (<600 mg/d). In this randomised cross-over design, fourteen adults with T2DM (49·5 (SD 8·6) years, BMI 29·4 (SD 4·5) kg/m2 ) consumed either MD or CD for 12 weeks, with a washout of 18 weeks between phases. A breakfast shake containing 700 mg (MD) or 6·4 mg (CD) of Ca was consumed in the laboratory. In addition, energyrestricted diets were prescribed (800 mg of dietary Ca/d). Waist circumference (WC), fasting glucose, fasting TAG, systolic (SBP) and diastolic blood pressure (DBP), fasting total cholesterol, fasting LDL-cholesterol, fasting HDL-cholesterol, HDL:LDL ratio, HDL:TAG ratio and lipid accumulation product (LAP) index were assessed at baseline and after each phase. Ca consumption during the study was equivalent to 1200 mg/d during MD and 525 mg/d during CD. There was a greater reduction in WC, SBP, DBP and LAP index after MD compared with CD. HDL:LDL ratio increased and total cholesterol, LDL-cholesterol, SBP, DBP and LAP index decreased only in MD. The consumption of approximately 1200 mg of Ca/d (700 mg from fat-free milk + 500 mg from other dietary sources) associated with an energy-restricted diet decreased some of the MetS components and cardiometabolic measures in adults with T2DM

Efect of vitamin A suplementation: a systematic review

Marcela Martins Soares, Mariane Alves Silva, Pauliana Pimentel Coelho Garcia, Luciana Saraiva da Silva, Glauce Dias da Costa, Raquel Maria Amaral Araújo, Rosângela Minardi Mitre Cotta
Ciência & Saúde Coletiva, 2018, p1-12
Impact factor: 0,780

Abstract: To evaluate the effect of vitamin A supplementation in postpartum infants and women on serum retinol levels and breast milk. The databases Medline, PubMed, Lilacs and SciELO were consulted. The descriptors used were vitamin A, dietary supplement, child, postpartum period,infant and nutrition programs policies. Search found 7432 articles. After elimination of duplicity and application of eligibility criteria, 8 studies remained. All evaluated the effect of vitamin A supplementation on immediate postpartum, five studies used retinyl palmitate supplementation,one with retinyl palmitate and two did not specify the form of supplementation. Six studies evaluated colostrum and two included supplementation of children. It was found that supplementation in the puerperium increases the concentrations of serum retinol and breast milk, however, this result was in the short term and was relevant when the previous concentrations of the mother were low. When maternal serum concentrations
are adequate, the retinol content in milk does not change, with little relevance for children. Further studies should be performed to evaluate the effect of megadoses supplementation on serum concentrations of children

Effects of blueberry and cranberry consumption on type 2 diabetes glycemic control: a systematic review

Daniela Mayumi Usuda Prado Rocha , Ana Paula Silva Caldas, Bárbara Pereira da Silva, Helen Hermana Hermsdorff, Rita de Cássia Gonçalves Alfenas
Critical Reviews in Food Science and Nutrition, 2018.
Impact factor: 6,077

Abstract: The metabolic effects of cranberry and blueberry consumption on glycemic control have been evaluated in vitro and in animal models as well as in human studies, although findings have not been systematically reviewed yet. Therefore, a systematic review was carried out of relevant randomized clinical trials (RCTs) in order to assess the effect of berries (blueberry and cranberry) consumption on type 2 diabetes (T2DM) glycemic control. Some evidences were also discussed on the anti-diabetic mechanisms exerted by berries polyphenols. Studies were identified by searching electronic databases: LILACS, PubMed/MEDLINE, Scopus, The Cochrane Library and Web of Science. Three authors independently searched and extracted RCTs in which the effect of berries (cranberry or blueberry) consumption on T2DM glycemic control was assessed. A total of 7 RCTs, involving 270 adults with type 2 diabetes were included. Despite the heterogeneity of the administration forms (in natura, dried, extract, preparations – juice), dosage, duration of the intervention and type of population of the studies involving these two berries some studies highlight the potential benefit of berries, especially of blueberry, on glucose metabolism in T2DM subjects. Daily cranberry juice (240 mL) consumption for 12 weeks and blueberry extract or powder supplementation (9.1 to 9.8 mg of anthocyanins, respectively) for 8 to 12 weeks showed a beneficial effect on glucose control in T2DM subjects. Those results indicate a promising use of these berries in T2DM management; although more studies are required to better understand the mechanisms involved.

Effects of exercise training and nebivolol treatment on atherosclerotic plaque development, iNOS expression and antioxidant capacity in apoE – /- mice

M.E.R. Alebrante; Mariana M. Dias; Clovis Andrade Neves; Damiana Diniz Rosa; Nathane P. Siqueira; Antonio José Natali; Maria do Carmo Gouveia Peluzio
Science & Sports. 2018.
Impact factor: 0,516

Abstract: Objectives: To assess the effects of exercise training and nebivolol either alone or in combination on the atherosclerotic plaque development, iNOS expression and antioxidant capacity in apolipoprotein E deficient (apoE−/− ) mice. Methods: Seventeen-week-old male apoE−/− mice were divided into four groups of seven animals each: Control (G1); Nebivolol (G2); Exercise (G3); and Nebivolol plus Exercise (G4). G3 and G4 animals were submitted to a swimming training program (60 min/day, 5 days/week) for six weeks. G2 and G4 animals received a daily dose of nebivolol (2.0 umol/kg) by gavage for six weeks. Atherosclerotic lesion area and iNOS expression in the aorta were measured. Catalase (CAT) and superoxide dismutase (SOD) activities were determined in the liver and kidney. Results: The atherosclerotic plaque was smaller in G2 compared to G1 group. iNOS expression occurred primarily in the adventitia layer of the aorta similarly in all groups. CAT activity was lower in the liver of exercised than non-exercised mice. The SOD activity in the liver was lower in G3 than in G1 and G2 groups. There were no differences between groups for SOD and CAT activities in the kidney. Conclusion: While aerobic exercise training reduces antioxidant activity in the liver, nebivolol treatment attenuates atherosclerotic plaque development in apoE−/− mice, but the expression of iNOS is not affected. The combination of treatments does not add on benefits.

Perception scales of validated food insecurity: the experience of the countries in Latin America and the Caribbean

Nayara Sperandio, Dayane de Castro Morais and Sílvia Eloíza Priore
Ciência e Saúde Coletiva, v. 23, p. 449-462
Impact factor: 0,78

Abstract: Resumo Objetivou-se nesta revisão sistemática comparar as escalas de insegurança alimentar validadas e utilizadas nos países latino-americanos e caribenhos, e analisar os métodos empregados nos estudos de validação. Realizou-se busca nas bases eletrônicas Lilacs, SciELO e Medline. As publicações foram pré-selecionas pelos títulos e resumos, e posteriormente pela leitura integral. Dos 16.325 estudos revisados, selecionou-se 14. Foram identificadas 12 escalas validadas para os seguintes países: Venezuela, Brasil, Colômbia, Bolívia, Equador, Costa Rica, México, Haiti, República Dominicana, Argentina e Guatemala. Além dessas, tem-se a escala latino-americana e caribenha cuja abrangência é regional. As escalas variaram em relação ao padrão de referência utilizado, nú- mero de questões e diagnóstico da insegurança. Os métodos empregados pelos estudos para validação interna foi o cálculo do coeficiente alfa de Cronbach e o modelo Rasch; para validação externa os autores calcularam associação e/ou correlação com variáveis socioeconômicas e de consumo alimentar. A exitosa experiência da América Latina e Caribe no desenvolvimento de escalas nacionais e regionais pode ser exemplo para outros países que ainda não possuem esse importante indicador capaz de dimensionar o fenômeno da insegurança alimentar

Evaluation of the health benefits of consumption of extruded tannin sorghum with infermented probiotic milk in individuals with chronic kidney disease

Rita de Cássia Stampini Oliveira Lopes, Samara Letícia Silva de Lima, Bárbara Pereira da Silva, Renata Celi Lopes Toledo, Maria Eliza de Castro Moreira, Pamella Cristine Anunciação, Eduardo Henrique Miranda Walter, Carlos Wanderlei Piler Carvalho, Valéria Aparecida Vieira Queiroz, Andréia Queiroz Ribeiro, Hércia Stampini Duarte Martino
Food Research International 107 (2018) 629–638
Impact factor: 3,086

Abstract: This study investigated the chemical and nutritional composition of breakfast cereal based on whole sorghum, and the effect of its association with unfermented probiotic milk on the inflammation and oxidative stress of individuals with chronic kidney disease. Extruded sorghum breakfast meal presented higher carbohydrate concentration (approximately 71%), followed by protein (approximately 11%) and lipid (approximately 0.4%). When compared to extruded maize breakfast meal, it presented higher percentage of dietary fiber (p < 0.05), and higher content of phenolic compounds and tannin, consequently higher antioxidant activity (p < 0.05). Extruded sorghum breakfast cereal combined with unfermented probiotic milk decreased the C-reactive protein (p < 0.05) and malondialdehyde (p < 0.05) serum levels and increased the total antioxidant capacity and superoxide dismutase (p < 0.05) in patients with chronic kidney disease. Therefore, the extruded sorghum, source of tannin, anthocyanin, and dietary fiber, when consumed with unfermented probiotic milk alleviates the inflammation and oxidative stress in patients with chronic kidney disease.

Extruded sorghum consumption associated with a caloric restricted diet reduces body fat in overweight men: a randomized controlled trial

Pamella Cristine Anunciaçãoa, Leandro de Morais Cardoso, Rita de Cássia Gonçalves Alfenas, Valéria Aparecida Vieira Queiroz, Carlos Wanderlei Piler Carvalho, Hércia Stampini Duarte Martino, Helena Maria Pinheiro-Sant’Ana
Food Research International, v.2018, p 1-8.
Impact factor: 3,086

Abstract: This study aimed to evaluate the effect of sorghum intake on body composition and metabolic variables in overweight men. In a randomized controlled crossover study, 24 overweight men (25.6 ± 4.6 years) were randomly allocated into one of two treatments: extruded sorghum or extruded wheat. The study consisted of 2 periods of 8 weeks with at least 4 weeks of washout. Anthropometric, clinical and metabolic risk variables were assessed at baseline and at the end of each intervention period. Extruded sorghum consumption reduced body fat percentage and increased daily carbohydrate and dietary fiber intake when compared to wheat consumption. Also, sorghum increased the serum glutathione peroxidase concentration, but no difference was observed when compared to wheat consumption. Extruded sorghum demonstrated to be a good alternative to control obesity in overweight men.

Physical Exercise and Regulation of Intracellular Calcium in Cardiomyocytes of Hypertensive Rats

Joel Alves Rodrigues, Thales Nicolau Prímola-Gomes, Leôncio Lopes Soares, Tiago Ferreira Leal, Clara Nóbrega, Danillo Laviola Pedrosa, Leonardo Mateus Teixeira Rezende, Edilamar Menezes de Oliveira, Antonio Jose Natali
Arquivos Brasileiro de Cardiologia v.111, p-172-179
Impact factor: 1,186

Abstract: Background: Regulation of intracellular calcium (Ca2+) in cardiomyocytes is altered by hypertension; and aerobic exercise brings benefits to hypertensive individuals. Objective: To verify the effects of aerobic exercise training on contractility and intracellular calcium (Ca2+) transients of cardiomyocytes and on the expression of microRNA 214 (miR-214) in the left ventricle of spontaneously hypertensive rats (SHR). Methods: SHR and normotensive Wistar rats of 16 weeks were divided into 4 groups –sedentary hypertensive (SH); trained hypertensive (TH); sedentary normotensive (SN); and trained normotensive (TN). Animals of the TH and TN groups were subjected to treadmill running program, 5 days/week, 1 hour/day at 60-70% of maximum running velocity for 8 weeks. We adopted a p ≤ 0.05 as significance level for all comparisons. Results: Exercise training reduced systolic arterial pressure in hypertensive rats. In normotensive rats, exercise training reduced the time to 50% cell relaxation and the time to peak contraction and increased the time to 50% decay of the intracellular Ca2+ transients. In SHR, exercise increased the amplitude and reduced the time to 50% decay of Ca2+ transients. Exercise training increased the expression of miR-214 in hypertensive rats only. Conclusion: The aerobic training applied in this study increased the availability of intracellular Ca2+ and accelerated the sequestration of these ions in left ventricular myocytes of hypertensive rats, despite increased expression of miR-214 and maintenance of cell contractility

Extruded sorghum flour (Sorghum bicolor L.) modulate adiposity and inflammation in high fat diet-induced obese rats

Priscila Marques Arbex, Maria Eliza de Castro Moreira, Renata Celi Lopes Toledo, Leandro de Morais Cardoso, Helena Maria Pinheiro-Sant’ana, Laércio dos Anjos Benjamin, Leandro Licursi, Carlos Wanderlei Piler Carvalho, Valeria Aparecida Vieira Queiroz, Hércia Stampini Duarte Martino
Journal of Functional Foods 42 (2018) 346–355
Impact factor: 3,144

Abstract: The aim was to determine the effect of extruded sorghum flour (ESF) on the adiposity and inflammation modulation in obese Wistar rats. Four experimental groups: normal control (AIN-93), obese control (HFD) and two tested groups (replacing 50% of cellulose and 100% of cornstarch by ESF in the HFD – HFDS50; and replacing 100% of cellulose and 100% of cornstarch by ESF in the HFD – HFDS100) were used. The luteolinidin and 5-methoxy-luteliolinidin were the main deoxyanthocianidins identified in ESF. The Lee index, percentage of adiposity, fatty acid synthase gene expression, TNF-α, blood levels of glucose and the adipocyte hypertrophy were lower in the groups treated with ESF when compared to HFD. The groups treated with ESF up-regulated the lipoprotein lipase, peroxisome proliferator activated receptor-γ gene expression and IL-10. ESF has potential as a functional food since it reduced the metabolic risk of obesity associated with adiposity and inflammation.

Factors associated with body adiposity index (BAI) in adults: population-based study

Wellington Segheto; Pedro Curi Hallal; João Carlos Bouzas Marins; Danielle Cristina Guimarãesda Silva; France Araújo Coelho; Andréia Queiroz Ribeiro; Sílvia Helena Oliveira Morais; Giana Zarbato Longo.
Ciência & Saúde Coletiva. 23(3):773-783, 2018.
Impact factor: 0,780

Abstract: The objective of this study was to analyze factors associated with the body adiposity index. A population-based, cross-sectional study was conducted with 964 adults between 20 and 59 years of age, in Viçosa, State of Minas Gerais, Brazil. Household questionnaires and anthropometric measurements were applied to obtain data. Multiple analysis was performed using linear regression, adjusted for the sampling design effect. The prevalence of excess body adiposity was 36.89 (CI 30.81 to 43.43), being higher among men (48.18% – CI 39.09 to 57.34). Factors positively associated with body adiposity index were: female sex (p = 0.002); age in years (p < 0.001); those living with a partner (p = 0.022). Self-evaluation of positive health (p = 0.048) was negatively associated with the body adiposity index. The prevalence of excess body fat was high and the sex, age, marital status, health self-evaluation and dissatisfaction with body image were determinant factors to the increase in body adiposity in this population, indicating a marked risk for chronic diseases resulting from excess body fat.

Family history is associated with the presence of dyslipidemia in pre‑school children

Mariana de Santis Filgueirasa, Sarah Aparecida Vieira, Andréia Queiroz Ribeiro, Juliana Farias de Novaes
Revista Paulista de Pediatria, v. 2018, p.1-8
Impact factor

Abstract: Objective: To evaluate the association between family history and the presence of dyslipidemia in children. Methods: A cross‑sectional study with 257 children aged 4 to 7 years old from Viçosa, Minas Gerais, Southeast Brazil. Nutritional status and lipid profile (total cholesterol, cholesterol fractions, and triglyceride) assessments and an active search for a family history of dyslipidemia in parents were carried out. Pearson’s chi‑square test was used to identify associations, and Student’s t‑test was used to compare means. A Poisson regression analysis was performed to assess the independent association between family history and the presence of dyslipidemia in children. A significance level of 5% was adopted. Results: Children of parents with dyslipidemia had higher serum concentrations of total cholesterol and triglycerides. In a regression analysis after adjustments, the presence of dyslipidemia in the father or in the mother (OR: 2.43; 95%CI 1.12–5.27), as well as the presence of dyslipidemia in both the father and the mother (OR:5.62; 95%CI 2.27–13.92) were associated with hypertriglyceridemia in children. Children of parents with dyslipidemia had a higher prevalence of elevated low-density lipoproteins (LDL‑c) (OR:1.52; 95%CI 1.18–1.97). Conclusions: An investigation of the family history of dyslipidemia should be made as part of the protocol to verify the presence of hypertriglyceridemia and dyslipidemia in children.

Food security and edible plant cultivation in the urban gardens of socially disadvantaged families in the municipality of Vicosa, Minas Gerais, Brazil

Hercilio Paulino André, Naiara Sperandio, Renata Lopes de Siqueira, Sylvia do Carmo Castro Franceschini e Silvia Eloiza Priore
Ciência e Saúde Coletiva, v.23, n.4, p. 1159-1167
Impact factor: 0,78

Abstract: This study aimed to review food and nutrition insecurity indicators associated with iron deficiency anemia in Brazilian children below 5 years. We searched in electronic databases (SciELO, Lilacs, and Medline) and selected studies by titles, abstracts and full-text reading. Of the 1,023 studies analyzed, 11 fit the inclusion criteria. The results of the studies evidenced that iron deficiency anemia in Brazilian children was associated with sociodemographic and health indicators (male, age below 24 months, children of adolescent mothers, respiratory infections, diarrhea, low maternal schooling, parents’ working conditions, nursery time, lack of basic sanitation, maternal anemia, lack of ferrous sulfate use by the mother and/or child and late onset of prenatal care), nutritional indicators (low birth weight, diet characteristics, such as the habit of milk consumption close to meals, low exclusive and full breastfeeding time) and economic indicators (low per capita income). The food and nutrition insecurity analyzed in this study from the perspective of different indicators is associated with iron deficiency anemia in children under 5 years in Brazil

Food security and edible plant cultivation in the urban gardens of socially disadvantaged families in the municipality of Vicosa, Minas Gerais, Brazil

Natalia Sant’Anna de Medeiros, Davi Lopes do Carmo, Sılvia Eloıza Priore, Ricardo Henrique Silva Santos, Carina Aparecida Pinto
Environment, Development and Sustainability. 2018.
Impact factor

Abstract: Subsistence farming in urban gardens may be a strategy for food and nutrition security, particularly in socially disadvantaged families, because it eases access to food. This study aimed to assess the following factors in socially disadvantaged families: (1) prevalence of food insecurity, (2) characterization of gardens and cultivation of edible plants in urban areas, and (3) relation between characteristics of urban gardens and cultivated edible plants and food security in families. A survey was conducted on the management and cultivation of plants in gardens and on the perception of food security according to the Brazilian Food Insecurity Scale for 118 families living in urban areas in the municipality of Vicosa, Minas Gerais, Brazil. We observed that 78.8% of families were ̧ exposed to food insecurity and were socially vulnerable. Among these, 56.8% experienced mild food insecurity conditions, 15.3% moderate conditions, and 6.7% severe conditions. Management of urban gardens and cultivation of edible plants vary widely according to families’ needs and interests, available space, age of farmers, cultivation time, and previous relationship between the family and rural environments. There was no relation between characteristics of gardens, management, and cultivation of edible plants in urban gardens and the perception of food security of socially disadvantaged families.

High-fat diet and alcohol intake promotes inflammation and impairs skin wound healing in wistar rats.

Daiane Figueiredo Rosa, Mariáurea Matias Sarandy, Rômulo Dias Novaes, Mariella Bontempo Freitas, Maria do Carmo Gouveia Pelúzio, and Reggiani Vilela Gonçalves
Mediators of inflamation, v.2018, p.1-12
Impact factor 3,232

Abstract: The wound-healing process is complex and remains a challenging process under the influence of several factors, including eating habits. As improper diets may lead to disorders such as dyslipidemia, insulin resistance, and chronic inflammation, potentially affecting the tissue ability to heal, we decided to investigate the effect of a high-fat diet and alcohol intake on the inflammatory process and skin wound healing in Wistar rats. Male rats (n = 30) were individually housed in cages with food and water ad libitum (registration number 213/2014). After anesthesia, at day 40, three circular wounds (12 mm diameter) were made on the back of each animal, which were then randomly assorted into five treatment groups: C1 (control 1)—water via gavage and standard chow diet; C2 (control 2)—water (no gavage) and standard chow diet; AL (alcohol)—water (no gavage) and alcohol (40%) via gavage and standard chow diet; HF (high fat)—water (no gavage) and high-fat diet (50%); and HF + AL (alcohol/high fat)—water (no gavage), alcohol (40%) via gavage, and high-fat diet. Animals were treated for 61 days. Every seven days, the area and the rate of wound contraction were evaluated. Tissue samples were removed for histopathological analysis and biochemical analyses. Our results showed that wound contraction was not complete in the HF + AL rats. Two specific indices of wound-healing impairment (total cell number and levels of the inflammatory cytokine TGF-β) were increased in the HF + AL rats. We also observed decreased type I and III collagen fibers in the HF, AL, and HF + AL groups and increased oxidative stress markers in the same groups. We suggest that a high-fat diet combined with alcohol intake contributed to delayed skin wound healing through increase of the inflammatory phase and promoting oxidative stress, which may have led to morphological alterations and impaired matrix remodeling

In vitro and in vivo resistance of lactobacillus rhamnosus gg carried by a mixed pineapple (Ananas Comosus L. Merril) and jussara (Euterpe Edulis Martius) juice to the gastrointestinal tract.

Renata Cristina de Almeida Bianchini Campos, Eliane Maurício Furtado Martins, Bruno de Andrade Pires, Maria do Carmo Gouveia Peluzio, André Narvaes da Rocha Campos, Afonso Mota Ramos, Bruno Ricardo de Castro Leite Júnior, Aurélia Dornelas de Oliveira Martins, Roselir Ribeiro da Silva, Maurilio Lopes Martins
Food Research International, v.2018
Impact factor: 3,086

Abstract: This study evaluated the viability of Lactobacillus rhamnosus GG (LGG) and its in vitro and in vivo resistance to the gastrointestinal tract (GIT) when carried by a mixed fermented pineapple and jussara juice. The effects of product ingestion on the biochemical characteristics of the blood and on the development of aberrant crypt foci (ACF) in Wistar rats were also determined. The LGG viability in probiotic juice was higher than 7.2 log CFU/mL throughout 28 days at 8 °C. The mean count of the probiotic microorganism in the fecal samples of the rats was 5.6 log CFU/g, identical to the count at the end of the in vitro trial (enteric phase II), indicating that the mixed pineapple and jussara juice was an excellent vehicle for LGG. No difference (p > .05) was verified to ACF among the groups. However, the results for the probiotic culture viability and its in vitro and in vivo resistance to the gastrointestinal tract suggest that this juice is an excellent carrier matrix for LGG and contributed to a reduction in the levels of the LDL (low density lipoprotein) fraction of the blood cholesterol, thus being an aid in the control of coronary diseases.

Increased ApoB/ApoA1 ratio is associated with excess weight, body adiposity, and altered lipid profile in children

Ana Paula Pereira Castro, Helen Hermana Miranda Hermsdorff, Luana Cupertino Milagres, Fernanda Martins de Albuquerque, Mariana De Santis Filgueiras, Naruna Pereira Rocha, Juliana Farias de Novaes
Jornal de Pediatria
Impact factor: 2,081

Abstract: Objective: To investigate ApoB/ApoA1 ratio and its association with cardiovascular risk factorsin children.Methods: Cross-sectional study with 258 children aged 8 and 9 years old, enrolled in all urbanschools in the city of Vic¸osa-MG. Anthropometric and body composition assessment, as wellas biochemical profile of the children was performed. Socioeconomic variables and sedentarylifestyle were evaluated through a semi-structured questionnaire.Results: Many children had excess weight (35.2%), abdominal adiposity (10.5%), and body fat(15.6%), as well as increased ApoB/ApoA1 ratio (14.7%), total cholesterol (51.8%), and trigly-cerides (19.8%). Children with excess weight and total and central fat had a higher prevalenceof having a higher ApoB/ApoA1 ratio, as well as those with atherogenic lipid profile (increasedLDL-c and triglycerides and low HDL-c). A direct association was found between the number ofcardiovascular risk factors and the ApoB/ApoA1 ratio (p = 0.001), regardless of age and income. Conclusion: The increased ApoB/ApoA1 ratio was associated with excess weight, body adiposity(total and central), and altered lipid profile in children. Children with a higher number ofcardiovascular risk factors had higher ApoB/ApoA1 ratio, in both genders.

Inverse association of calcium intake with abdominal adiposity and C-reactive protein in Brazilian children

Lara Gomes Suhett; Brenda Kelly Souza Silveira; Mariana De Santis Filgueiras; Maria do Carmo Gouveia Peluzio; Helen Hermana Miranda Hermsdorff; Juliana Farias de Novaes
Public Health Nutrition. 2018.
Impact factor: 2,152

Abstract: Objective: To evaluate Ca intake and its association with cardiometabolic risk factors during childhood. Design: A cross-sectional study with a representative sample. Food consumption was assessed through three 24 h dietary recalls. Anthropometry, body composition and biochemical measurements were also conducted. Setting: Viçosa, Minas Gerais, Brazil. Subjects: Children between 8 and 9 years old (n 350) enrolled in public and private schools in the urban area of the municipality of Viçosa. Results: Almost all children had inadequate intake of Ca (97·4 %), especially those with low income, non-white and who studied in public schools. Foods that contributed most to Ca intake were ‘milk’ and ‘cheeses and yoghurts’ (R2 = 0·66 and 0·13, respectively), and intake of ‘milk’ was correlated with ‘chocolate milk powder’ intake (r = 0·538, P < 0·01). Children with lower Ca intake had a higher prevalence of increased C-reactive protein (prevalence ratio = 2·93; 95 % CI 1·21, 7·07), increased waist circumfNutr Hosp 201Critical Reviews in Food Science and Nutrition 8;35:176-184 erence (prevalence ratio = 2·86; 95 % CI 1·01, 8·13) and a lower prevalence of high LDL cholesterol (prevalence ratio = 0·64; 95 % CI 0·41, 0·99). Conclusions: Lower Ca intake was associated with excess abdominal adiposity and subclinical inflammation in Brazilian children. Monitoring of adequate Ca intake is important, especially in poorer communities.

Iron biofortified carioca bean (Phaseolus vulgaris l.)-based brazilian diet delivers more absorbable iron and affects the gut microbiota in vivo (Gallus gallus)

Desirrê Morais Dias, Nikolai Kolba, Dana Binyamin, Oren Ziv, Marilia Regini Nutti, Hércia Stampini Duarte Martino, Raymond P. Glahn, Omry Koren and Elad Tako
Nutrients, v. 10, p.1970-1980
Impact factor: 3,550

Abstract: Biofortification aims to improve the micronutrient concentration and bioavailability in staple food crops. Unlike other strategies utilized to alleviate Fe deficiency, studies of the gut microbiota in the context of Fe biofortification are scarce. In this study, we performed a 6-week feeding trial in Gallus gallus (n = 15), aimed to investigate the Fe status and the alterations in the gut microbiome following the administration of Fe-biofortified carioca bean based diet (BC) versus a Fe-standard carioca bean based diet (SC). The tested diets were designed based on the Brazilian food consumption survey. Two primary outcomes were observed: (1) a significant increase in total body Hb-Fe values in the group receiving the Fe-biofortified carioca bean based diet; and (2) changes in the gut microbiome composition and function were observed, specifically, significant changes in phylogenetic diversity between treatment groups, as there was increased abundance of bacteria linked to phenolic catabolism, and increased abundance of beneficial SCFA-producing bacteria in the BC group. The BC group also presented a higher intestinal villi height compared to the SC group. Our results demonstrate that the Fe-biofortified carioca bean variety was able to moderately improve Fe status and to positively affect the intestinal functionality and bacterial populations.

Liver Histology after Chronic Use of Alcohol and exercise training in rats

Marina Silva de Lucca, Eveline Torres Pereira, Thamires Righi, Camilo Amaro de Carvalho, Clayton Israel Nogueira, Daise Nunes Queiroz da Cunha, Antônio José Natali, Luciana Moreira Lima
Journal of Pharmacy and Pharmacology 6 (2018) 52-60
Fator de Impacto: 2,405

Abstract: Objectives: To investigate the effects of physical training on the liver morphology and morphometry after chronic use of alcohol in rats. Methods: Twenty-four Wistar rats were housed in cages with controlled environment and randomly divided into four groups according to treatment received. In the initial treatment, alcohol was administered to SA (sedentary alcohol) and EA (exercise alcohol) groups. After four weeks, physical training program was held on a treadmill with EA and EC (exercise control) groups. Area, perimeter, maximum and minimum diameter and form factor of nucleus and cytoplasm of hepatocytes were analyzed. Key findings: Micro-vesicular fatty degeneration, predominantly pericentrolobular, of mild to moderate intensity, was found especially in animals treated with alcohol. EC group showed nucleus area greater than the nucleus area of EA and SA groups. The form factor was lower in the EC group than in the EA group. EA group showed maximum cytoplasm diameter is smaller than in SC (sedentary control) group. Conclusions: Physical training for two weeks was not enough to suppress histopathologic changes in the liver caused by chronic use of alcohol in rats. Chronic use of alcohol seems to have minimized the beneficial effect of physical training in the nucleus area of hepatocytes.

Lower vitamin D intake associated with low hdl-cholesterol and vitamin d insufficiency/deficiency in brazilian children.

Mariana De Santis Filgueiras, Lara Gomes Suhett, Mariane Alves Silva, Naruna Pereira Rocha and Juliana Farias de Novaes
Public Health Nutrition, v. 2018, p.1-9
Impact factor: 2,326

Abstract: Objective: To evaluate the association of vitamin D intake with dyslipidaemia and vitamin D insufficiency/deficiency in Brazilian children and identify the main food group sources of this nutrient in the sample. Design: A cross-sectional study carried out with a representative sample. Blood was collected after 12 h of fasting. Laboratory tests were performed to determine total cholesterol, HDL cholesterol (HDL-C), LDL cholesterol, TAG, apoB, apoA1, 25-hydroxyvitamin D and parathyroid hormone. Dietary intake was evaluated by a 24 h recall. Setting: Viçosa, Minas Gerais, Brazil. Subjects: Children between 8 and 9 years old enrolled in urban schools (n 378). Results: We found an elevated prevalence of inadequate vitamin D intake (91·3 %), dyslipidaemia (72·8 %) and vitamin D insufficiency/deficiency (56·2 %). The food groups that contributed the most to vitamin D intake were dairy products and fish. Lower vitamin D intake was associated with increased prevalence of both low HDL-C (prevalence ratio=2·51; 95 % CI 1·02, 6·18; P<0·05) and vitamin D insufficiency/deficiency (prevalence ratio=1·61; 95 % CI 1·01, 2·58; P<0·05). Conclusions: Given the elevated prevalence of inadequate vitamin D intake and its association with low HDL-C and vitamin D insufficiency/deficiency, it is important to develop specific actions in food and nutritional education as well as programmes that stimulate and facilitate access to vitamin D food sources, such as dairy products and fish.

Mango leaf tea promotes hepatoprotective effects in obese rats

Natalia Medina Ramíreza, José Humberto de Queiróz, Sônia Machado Rocha Ribeiro, Renata Celi Lopes Toledo, Maria Eliza Castro Moreira, Claudio Lisías Mafra, Laércio dos Anjos Benjamin, Camila de Morais Coelho, Marcia Paranho Veloso, Hércia Stampini Duarte Martino
Journal of Functional Food, v. 49, p.437-446
Impact factor: 3,144

Abstract: As mango leaf tea contains mangiferin and other bioactive compounds, this study investigated its anti-inflammatory, antioxidant and hepatoprotective effects on rats with high-fat induced obesity. Three groups were established: a control group (AIN93M diet), an obese group (high-fat diet HFD) and a treatment group (HFD with mango leaf tea for 8 weeks). Mango leaf tea increased antioxidant enzymes, total antioxidant capacity, AdipoR2 and PPAR-α mRNA and proteins expressions and, it also inhibited the NF-κB p65 and SREBP1c genes expressions in the liver. This beverage also leads to Cpt1 overexpression and a significant decrease in the accumulation of fat droplets, improving the hepatic steatosis. Molecular docking suggested a positive interaction between mangiferin, the main bioactive compound of mango leaf tea, and PPAR-α. Mango leaf tea exhibited a hepatoprotective effect through activating PPARα and decreasing the NF-κB p65 expressions, reducing oxidative stress and steatosis, and improving the lipid metabolism.

Maternal smoking during pregnancy and early development of overweight and growth deficit in children: an analysis of survival

Poliana Cristina de Almeida Fonseca, Carolina Abreu de Carvalho, Vitória Abreu de Carvalho, Andréia Queiroz Ribeiro, Silvia Eloiza Priore, Sylvia do Carmo Castro Franceschini e Sarah Aparecida Vieira
Revista Brasileira de Saúde Materno Infantil, v.18, p.361-369

Abstract: Objectives: to evaluate the association between smoking during pregnancy and nutritional status. Methods: cohort study with a sample of 460 children in the baseline. The children were assessed four times, being measured for weight and length to be converted in indexes length forage (L/A) and body mass index forage (BMI/A) in Z-score. The time until occurrence of growth deficit and overweight was calculated in days and compared to maternal smoking during pregnancy. To assess the association between smoking during pregnancy and the outcomes, a Hazard Ratio by Cox regression was obtained, adjusting by confounding variables selected from Directed Acyclic Graphs (DAG).Results: the time until occurrence of growth deficit and overweight was lower in children whose mothers smoked during pregnancy. Smoking during pregnancy was a risk factor for length deficit (HR = 2.84; CI95% = 1.42 to 5.70) and for overweight (HR = 1.96; CI95% = 1, 09 to 3.53), even after the adjustment. Conclusions: maternal smoking was a changeable factor associated with anthropometric outcomes, which demonstrates the need for actions to combat smoking during pregnancy in order to prevent early nutritional deviations

Metabolic, inflammatory and oxidative stress markers in the nitric oxide variation of hemodialysis subjects

Andreza P. Santos Epifânio, Karka P. Balbino, Mônica de P. Jorge, Sônia. M. R. Ribeiro, Ana Vládia B. Moreira, Jerusa M. Oliveira, Leandro L. Oliveira and Helen Hermana M. Hermsdorff
Nutrición Hospitalaria 2018;35:176-184 .
Impact factor: 0,747

Abstract: Introduction: Oxidative stress markers such as nitric oxide (NO) have been investigated in hemodialysis (HD). Objective: Evaluate the association of NO variation with adiposity indicators, metabolic, inflammatory and oxidative stress markers in individuals to HD. Methods: Cross-sectional study with 85 subjects on HD treatment (≥ 18 years). The clinical-nutritional status was evaluated through subjective global assessment modified (SGAm), anthropometric measurements and body composition. Dietary intake was evaluated using a food frequency questionnaire. Metabolic marpage 1 of 9 kers were obtained from medical records. Inflammatory markers (IL-6 and IL-10) and oxidative stress, (TACs), (SOD), (GST), (MDA) and NO were determined using standardized protocols. Results: Those individuals with a high concentration of NO (> 4.32 μmol/L) had lower values for SGAm score (p = 0.012) and higher iron values (p = 0.050), Fe saturation (p = 0.037) and triacylglycerol (p = 0.003). The same subjects still had lower consumption of copper (p = 0.026), manganese (p = 0.035), vitamin E (p = 0.050), ω3 (p = 0.021) and ω6 (p = 0.020). In a multiple regression model, concentrations of ferritin, triacylglycerol, IL6 and SOD contributed to a 54.8% increase in NO concentrations, whereas triacylglycerol and SOD concentrations were independent factors for NO variation (p < 0.001). Conclusions: The clinical and nutritional status as well as intake of nutrients with antioxidant properties (Cu, Zn, Mn, vitamin C and ω3) appears to modulate the variation of NO in this population.

Moderate Continuous Aerobic Exercise Training Improves Cardiomyocyte Contractility in 1 Adrenergic Receptor Knockout Mice

Aurora Corrêa Rodrigues, Antônio José Natali, Daise Nunes Queiroz da Cunha, Alexandre Jayme Lopes Dantas Costa, Anselmo Gomes de Moura, Miguel Araújo Carneiro-Júnior,1 Leonardo Bonato Félix, Patrícia Chakur Brum, Thales Nicolau Prímola-Gomes
Arquivos Brasileiros de Cardiologia, v. 110, p. 256-262
Impact factor: 1,186

Abstract: Background: The lack of cardiac β1 -adrenergic receptors (β1 -AR) negatively affects the regulation of both cardiac inotropy and lusitropy, leading, in the long term, to heart failure (HF). Moderate-intensity aerobic exercise (MCAE) is recommended as an adjunctive therapy for patients with HF. Objective: We tested the effects of MCAE on the contractile properties of left ventricular (LV) myocytes from β1 adrenergic receptor knockout (β1 ARKO) mice. Methods: Four- to five-month-old male wild type (WT) and β1 ARKO mice were divided into groups: WT control (WTc) and trained (WTt); and β1 ARKO control (β1 ARKOc) and trained (β1 ARKOt). Animals from trained groups were submitted to a MCAE regimen (60 min/day; 60% of maximal speed, 5 days/week) on a treadmill, for 8 weeks. P ≤ 0.05 was considered significant in all comparisons. Results: The β1 ARKO and exercised mice exhibited a higher (p < 0.05) running capacity than WT and sedentary ones, respectively. The β1 ARKO mice showed higher body (BW), heart (HW) and left ventricle (LVW) weights, as well as the HW/BW and LVW/BW than WT mice. However, the MCAE did not affect these parameters. Left ventricular myocytes from β1 ARKO mice showed increased (p < 0.05) amplitude and velocities of contraction and relaxation than those from WT. In addition, MCAE increased (p < 0.05) amplitude and velocities of contraction and relaxation in β1 ARKO mice. Conclusion: MCAE improves myocyte contractility in the left ventricle of β1 ARKO mice. This is evidence to support the therapeutic value of this type of exercise training in the treatment of heart diseases involving β1 -AR desensitization or reduction.

Modulation of intestinal microbiota, control of nitrogen products and inflammation by pre/probiotics in chronic kidney disease: a systematic review

Rita de Cássia Stampini Oliveira Lopes, Karla Pereira Balbino, Mônica de Paula Jorge, Andréia Queiroz Ribeiro, Hércia Stampini Duarte Martino and Rita de Cássia Gonçalves Alfenas
Nutricion Hospitalaria, v.35, p.722-730
Impact factor: 0,747

Abstract: Dysbiosis may favor the occurrence of inflammation and oxidative stress in chronic kidney disease (CKD). It has been suggested that the intake of pre/probiotics may control the progression of chronic kidney disease. Thus, the objective of this study was to systematically review the literature on the effects of pre/probiotic intake on the intestinal microbiota, control of nitrogen products, oxidative stress, and inflammation in CKD patients. The literature search was conducted on MEDLINE, LILACS, Cochrane Library of Clinical Trials, and Science Direct. After careful evaluation by the reviewers, ten potentially relevant articles were selected for this study. Based on previous studies, intake of prebiotics appears to have the following effects: increased bifidobacteria and lactobacillus counts; reduced formation of uremic toxin, p-cresol, and its serum concentrations; improved lipid profiles; reduced systemic inflammatory state and concentrations of oxidative stress markers. Similarly, consumption of probiotics can reduce blood urea and serum phosphate concentrations. Furthermore, an increase in fecal volume and intestinal Bifidobacterium and a reduction in p-cresol serum and blood urea concentrations were observed in response to symbiotic intake. These results suggest that consumption of pre/ probiotics may modulate the intestinal microbiota, and promote the growth and metabolism of anaerobic bacteria by decreasing the production of uremic solutes, further causing oxidative stress and systemic inflammation in CKD patients.

Mourning and takotsubo cardiomyopathy: neuroendocrine implications and nutritional management.

Maria Teresa Fialho de Sousa Campos, Francisco Miguel Quintão Valente, Raquel Maria Amaral Araújo e Josefina Bressan
Revista da Associação Médica Brasileira, v. 64, p. 100-107

Abstract: This article aims to make reference to some recent mourning aspects considered risk factors for cardiovascular disease, specifically the Takotsubo cardiomyopathy. The objective was to describe the stress from the death of a loved one combining it to the possibility of occurrence of Takotsubo cardiomyopathy through the perception of a traumatic event by the cortex, which triggers the subcortical brain circuit affecting the endocrine response. Given the growing acknowledgement of this cardiomyopathy, it is possible to contextualize the nutritional behaviours and decisions surrounding it, whose benefits must exceed the condition of temporary cardiac dysfunction and extend to food choices that have some influence in the limbic system. It is a descriptive analysis that aims to problematize the theme into reflections based on this experience, considering the foundation with the science of nutrition

Nutritional risk in pediatrics by strongkids: a systematic review

Carolina Araújo dos Santos, Andréia Queiroz Ribeiro, Carla de Oliveira Barbosa Rosa,
Vânia Eloisa de Araújo e Sylvia do Carmo Castro Franceschini
European Journal of Clinical Nutrition, v. 2018, p.1-9
Impact factor: 3,057

Abstract: Background/objective The nutritional risk in hospitalized children and adolescents is a frequent and under-diagnosed reality. There is still no consensus regarding the best nutritional screening method in pediatrics, with StrongKids being one of the existing proposals. A systematic review was performed to evaluate the scientific evidence about StrongKids, with emphasis on the world frequency of nutritional risk, associations of interest in health, validation and reproducibility studies. Methods Databases Pubmed, Lilacs, Scielo, ScienceDirect, Web of Science, Scopus and Cochrane Library were searched, using keyword “StrongKids,” without limit on the year of publication, in English, Spanish, and Portuguese. Results From 125 papers initially identified, 22 original were included in analysis. The sample size ranged from 43 to 2874, with a maximum of 44 hospitals. The frequency of nutritional risk (medium or high) ranged from 35.7 to 100%. The nutritional risk was mainly associated with acute and/or chronic malnutrition already installed, lower anthropometric indexes and longer length of hospital stay. The method presented satisfactory inter-rater and intra-rater agreements and was validated in the three studies performed with this proposal. Conclusions The prevalence of nutritional risk in hospitalized children and adolescents is high. StrongKids is a valid, easy-to-use, and reproducible method, with significant associations of interest in health.

Polymorphism related to cardiovascular risk in hemodialysis subjects: a systematic review

Karla Pereira Balbino, Helen Hermana Miranda Hermsdorff, Josefina Bressan
Jornal Brasileiro de Nefrologia, v.40, n.2, p. 179-192
Impact factor

Abstract: A doença cardiovascular (DCV) é uma das principais causas de mortalidade de indiví- duos em hemodiálise (HD). Além dos fatores de risco tradicionais, que são frequentes nesses indivíduos, também estão envolvidos fatores genéticos, com destaque para os polimorfismos de nucleotídeo único (do inglês, single nucleotide polymorphism, SNP). O presente trabalho tem como objetivo revisar sistematicamente os estudos que investigaram os polimorfismos associados ao risco cardiovascular nessa população. De modo geral, os SNPs presentes em indivíduos em HD são aqueles de genes relacionados à inflamação, estresse oxidativo e calcificação vascular, também capazes de interferir no risco cardiovascular dos pacientes. Polimorfismos em genes relacionados a fatores de risco reconhecidos para DCV, como dislipidemia, hipertensão arterial e hipertrofia ventricular esquerda, também influenciam a morbidade e mortalidade cardiovascular.

Postprandial Lipid Response to High-Saturated and High-Monounsaturated Fat Meals in Normal- Weight or Overweight Women

Lílian L. Lopes, Daniela Mayumi U. P. Rocha, Alessandra da Silva, Maria do Carmo G. Peluzio, Josefina Bressan & Helen Hermana M. Hermsdorff
Journal of the American College of Nutrition, 2018.
Impact factor: 2,107

Abstract: Purpose: We evaluated postprandial response of the lipid metabolism markers after the intake of a high-saturated fat (HSM) or high-monounsaturated fat meal (HMM). Methods: A randomized, controlled and acute intervention study included 63 women (age 26.9 ± 6.1 years): 35 normal weight (NW) and 28 overweight (OW) (total body fat [TBF] 24.7 ± 3.9% and 36.6 ± 3.9%, respectively). After 12 hours of fasting, each subject was given one of the two test meals standardized, including 2 muffins and water (HSM, 42.1% of saturated fat acid, or HMM, 34.5% of monounsaturated fat acid). Plasma fatty acid profile and concentrations of apolipoproteins A1 and B100, complement C3, and triacylglycerols were analyzed during fasting and at 2, 3, and 5 postprandial hours. Results: Among the markers studied, the triacylglycerol (TAG) and complement C3 were significantly higher in the OW group, compared to NW. The increment in the C3 concentration was higher after HSM intake, compared with HMM (iAUC = 4365.5 ± 5477.4 vs. 1215.2 ± 882.4; p = 0.006), with no differences between groups. After 5 hours postprandial, plasma oleic acid values remained high compared with the fasting value in the NW group, but not in the OW group (26.0 ± 4.2 vs 23.7 ± 3.9%; p < 0.001). Women with high percentage of total plasma saturated fatty acids (SFA) at the beginning of the intervention had higher incremental area under the curve (iAUC) for the palmitic, stearic, and total fatty acids (p < 0.005). Those women with a high percentage of monounsaturated fatty acids (MUFA) showed lower iAUC values for the same fatty acid profile (p < 0.005). Conclusion: This study demonstrated the effect of the HSM on postprandial increment of C3 concentration, suggesting another mechanism for saturated fat metabolism. The postprandial response to HSM appears to be the mediated by baseline lipid profile of the individuals, while the response to HMM was correlated to the weight status.

Predictive capacity of indicators of adiposity in the metabolic syndrome in the elderly individuals

Keila Bacelar Duarte de Morais, Karina Oliveira Martinho, Fernanda Silva Franco, Milene Cristine Pessoa, Andreia Queiroz Ribeiro
Revista de Nutrição, v.31, n.2, p. 199-209
Impact factor: 0,333

Abstract: Objective To evaluate the predictive ability of adiposity indicators as MetS predictors in elderly individuals. Methods Cross-sectional study enrolled in the Estratégia Saúde da Família (Family Health Strategy). Anthropometric measurements were measured. Body Mass Index, Waist-Hip Ratio, Waist-Height Ratio, Conicity Index and Body Adiposity Index were calculated. Blood was collected and resting blood pressure was measured. MetS was classified according to the harmonizing criteria. The predictive ability of anthropometric variables was evaluated using Receiver Operating Characteristic curves. Results Regarding male individuals, our research indicates that the BMI, Waist-Height Ratio and Waist Hip Ratio are better predictors and they are equivalent to each other. As for female individuals, results show that the Body Mass Index and Waist-Height Ratio are better predictors and equivalent to each other. Conclusion Waist-Height Ratio and Body Mass Index are good MetS predictors for elderly individuals, especially among men. More research in this area is important. Comitê de Ética em Pesquisa com Seres Humanos da Universidade Federal de Viçosa. (Viçosa University Ethics Committee in Research with Human Beings) (nº 039/2011).

Clinical-nutritional, inflammatory and oxidative stress predictors in hemodialysis mortality: a review

Andreza P. S. Epifânio, Karla P. Balbino, Sônia M.R. Ribeiro, Sylvia C.C. Franceschini and Helen Hermana M. Hermsdorff
Nutricion Hospitalaria, v.45, p.461- 468
Impact factor: 0,747

Abstract: The evaluation of clinical-nutrition status is essential to increase life quality and improve clinical outcomes of patients in hemodialysis (HD). In the absence of a gold standard, the goal of this integrative review was to present and discuss the latest scientific literature on the ability of clinical-nutritional indicators and inflammatory and oxidative stress markers to predict morbidity and mortality in HD. In this context, the lean and fat mass indexes have become good predictors of mortality in HD individuals, regardless of BMI. Subjective scoring systems have been more sensitive to malnutrition, and altogether anthropometric indicators may result in an early detection of mortality risk in this population. On the other hand, inflammation in HD, as assessed by C-reactive protein, is not only related to cardiometabolic alterations, but it is also one of the key-points in the development of malnutrition, exacerbated by the state of oxidative stress, which has been identified in this group by the increase of the serum levels of gamma-glutamyl transferase and malondialdehyde.

Pretreatment and treatment with fructo-oligosaccharides attenuate intestinal mucositis induced by 5-fu in mice

Flávia Mendes Peradeles Galdino, Maria Emília Rabelo Andrade, Patrícia Aparecida Vieira de Barros, Simone de Vasconcelos Generoso, Jacqueline Isaura Alvarez-Leite, Camila Megale de Almeida-Leite, Maria do Carmo Gouveia Peluzio, Simone Odília Antunes Fernandes, Valbert Nascimento Cardoso
Journal of functional foods, v. 49, p. 485-492.
Impact factor: 3,144

Abstract: Mucositis is a side effect observed in patients undergoing chemotherapy. Besides, this treatment also leads to the imbalance of the intestinal microbiota. This study evaluated the effects of pre and treatment with fructo-oligosaccharides (FOS) in intestinal mucositis induced by 5-fluorouracil (5-FU). Balb/c mice were divided into four groups: CTL (without mucositis + saline), MUC (mucositis + saline), PT (mucositis + 6% FOS before disease induction) and T (mucositis + 6% FOS after disease induction). Mucositis was induced with an intraperitoneal injection of 300 mg/kg 5-FU. After 72 h intestinal permeability (IP), inflammatory infiltrate, oxidative stress, histological analysis, and short-chain fatty acids (SCFA) production were evaluated. The MUC group showed lost weight, intense inflammatory infiltrate, increased oxidative stress and IP (P < 0.05). FOS supplementation attenuated all these parameters (P < 0.05). Only pretreatment was able to maintain the acetate and butyrate production. These results showed that FOS supplementation presented protective effects on intestinal barrier function.

Promoting a healthy diet in childhood: weaknesses in the context of Primary Health Care

Ariadne Barbosa do Nascimento Einloft, Rosângela Minardi Mitre Cotta, Raquel Maria Amaral Araújo
Ciência & Saúde Coletiva, v. 23, p. 61-72, 2018
Impact factor: 0,780

Abstract: This paper reports the experience of the incorporation of perceptions of social actors in the investigation of the weaknesses of the process of implementation of programs that aim to promote a healthy diet in childhood. It involves qualitative research carried out in a medium-sized Brazilian municipality in which the participants were nurses and community health agents. The data were collected through semi-structured questionnaires as well as focus groups. The findings indicated
that the quality and continuity of actions to promote a healthy diet were limited due to the precarious working conditions, hence the strong demand for adequate orientation due to the unfavorable context where child health is concerned. Although the reality of peripheral countries points to an incipience in program evaluation, the incorporation of qualitative investigation broadened by the perspective of the participants may constitute an important tool of participation and social responsibility. This minimizes political effects and verticalized and discontinuous actions, helping the generation of opportune and adequate information for the understanding of the different local contexts and social experiences

Regulatory roles of mir-155 and let-7b on the expression of inflammation-related genes in thp-1 cells: effects of fatty acids.

J. L. Marques-Rocha, M. Garcia-Lacarte, M. Samblas, J. Bressan, J.A. Martínez, F.I. Milagro
Journal of Physiology and Biochemistry, v.2018, p.1-11
Impact factor: 2,444

Abstract: The main aim of this investigation was to study the regulatory roles of let-7b and miR-155-3p on the expression of inflammation-associated genes in monocytes, macrophages, and lipopolysaccharide (LPS)-activated macrophages (AcM). A second goal was to analyze the potential modulatory roles of different fatty acids, including oleic, palmitic, eicosapentaenoic (EPA), and docosahexaenoic (DHA), on the expression of these miRNAs in the three cell types. This hypothesis was tested in human acute monocytic leukemia cells (THP-1), which were differentiated into macrophages with 2-O-tetradecanoylphorbol-13-acetate (TPA) and further activated with LPS for 24 h. Monocytes, macrophages, and AcM were transfected with a negative control, or mimics for miR-155-3p and miR-let-7b-5p. The expression of both miRNAs and some proinflammatory genes was analyzed by qRT-PCR. Interestingly, let-7b mimic reduced the expression of IL6 and TNF in monocytes, and SERPINE1 expression in LPS-activated macrophages. However, IL6, TNF, and SERPINE1 were upregulated in macrophages by let-7b mimic. IL6 expression was higher in the three types of cells after transfecting with miR-155-3p mimic. Similarly, expression of SERPINE1 was increased by miR-155-3p mimic in monocytes and macrophages. However, TLR4 was downregulated by miR-155-3p in monocytes and macrophages. Regarding the effects of the different fatty acids, oleic acid increased the expression of let-7b in macrophages and AcM and also increased the expression of miR-155 in monocytes when compared with DHA but not when compared with non-treated cells. Overall, these results suggest anti- and proinflammatory roles of let-7b and miR-155-3p in THP-1 cells, respectively, although these outcomes are strongly dependent on the cell type. Noteworthy, oleic acid might exert beneficial antiinflammatory effects in immune cells (i.e., non-activated and LPS-activated macrophages) by upregulating the expression of let-7b.

The effect of micronized corn fiber on body weight, glycemia, and lipid metabolism in rats fed cafeteria diet

Vanessa Barbosa de Moraes Thompson, Neuza Maria Brunoro Costa, Hércia Stampini Duarte Martino, Maria Cristina Dias Paes
Food Science and technology, v.2018, p.1-5
Impact factor

Abstract: During corn industrial dry milling, a residue rich in dietary fibers is generated. This study aimed to evaluate the effects of micronized corn fiber (MCF) as part of a cafeteria diet in the macronutrient metabolism and body weight. Wistar male rats, with initial body weight of 249 ± 14 g (n = 13), received AIN-93M diet (Group 1) or cafeteria diet (Groups 2, 3 and 4), composed of commercial ration, cookies, fried potato sticks, milk chocolate, bacon and chicken liver pâté. Groups 3 and 4 received MCF to replace 100 and 50% of the cellulose from the AIN-93M diet, respectively. After 35 days, blood, tissues and feces were collected. Data were analyzed by ANOVA followed by Tukey test (p < 0.10). The weight gain of the animals increased by 25.9%, 20.8% and 22.0%, when fed cafeteria diet or 100 and 50% of MCF respectively, compared to the control group, although food consumption did not differ between them. Body weight and food efficiency ratio did not differ between the groups fed cafeteria diet with or without MCF. The addition of MCF to the cafeteria diet did not alter the animal lipid profile and glycemia, however, the accumulation of lipids in their livers was similar to the control group. The intake of 100% MCF resulted in higher fecal weight and fecal excretion of lipids, and lower fecal nitrogen, lipid absorption and lipid deposition in the liver than the cafeteria diet. In conclusion, MCF has a potential to improve intestinal transit and lipid excretion, but showed no benefit on blood lipid and glucose levels.

The importance of dysphagia screening and nutritional assessment in hospitalized patients

Patrícia Amaro Andrade, Carolina Araújo dos Santos, Heloísa Helena Firmino, Carla de Oliveira Barbosa Rosa
Einstein, v. 16, n.2, p. 1-6.
Impact factor

Abstract: Objective: To determine frequency of dysphagia risk and associated factors in hospitalized patients as well as to evaluate nutritional status by using different methods and correlate the status with scores of the Eating Assessment Tool (EAT-10). Methods: This was a cross-sectional study including 909 inpatients of a philanthropic hospital. For the diagnosis of dysphagia we used an adapted and validated Brazilian version of the Eating Assessment Tool (EAT-10). The nutritional status was evaluated through the subjective global assessment, and anthropometric measurements included weight, calf and arm circumference, and knee height. The MannWhitney test, associations using the Pearson’s χ2 and Spearman’s correlation were used to verify differences between the groups. Results: The prevalence of dysphagia risk was 10.5%, and aging was the associated factor with this condition. Patients at risk presented lower values of arm and calf circumference, variables that correlated inversely with the Eating Assessment Tool (EAT-10) score. Malnutrition was observed in 13.2% of patients based on the subjective global assessment and in 15.2% based on the Body Mass Index. Conclusion: Screening for dysphagia and malnutrition should be introduced in hospitals routine to avoid or minimize damages caused by dysphagia or malnutrition, especially among older people

The TyG index cutoff point and its association with body adiposity and lifestyle in children

Sarah A. Vieira-Ribeiro, Poliana C.A. Fonseca, Cristiana S. Andreoli, Andréia Q. Ribeiro, Helen H.M. Hermsdorff, Patrícia F. Pereira, Silvia E. Priore, Sylvia C.C. Franceschini
Jornal de Pediatria, 2018
Impact factor: 2,081

Abstract: Objective: To investigate the factors associated with insulin resistance in children aged 4—7years, and to identify the cutoff point of the triglyceride-glucose index for the prediction ofinsulin resistance in this population. Methods: A cross-sectional study was conducted with 403 children from a retrospective cohort. Insulin resistance was also evaluated in a sub-sample using the HOMA index. Four indicators ofbody adiposity were assessed: body mass index, waist-to-height ratio, and the percentages oftotal and central body fat. Food habits were evaluated by the identification of dietary patterns,using principal component analysis. Information was also collected on lifestyle, socioeconomicstatus, and breastfeeding time. Results: The median index observed in the sample was 7.77, which did not differ between thegenders. The shorter the time spent in active activities, the higher the triglyceride-glucosevalue; and increase in the values of body adiposity indicators was positively associated withtriglyceride-glucose. The cutoff point with the best balance between sensitivity and specificityvalues was 7.88 (AUC = 0.63, 95% CI: 0.51—0.74). Conclusion: The present study identified that total and central body adiposity and shorter timespent in lively activities was positively associated with insulin resistance, evaluated through thetriglyceride-glucose index. The cutoff point of 7.88 may be used in this population for insulinresistance risk screening, but caution is required when using it in other populations.

The use of antimicrobials as adjuvant therapy for the treatment of obesity and insulin resistance: effects and associated mechanisms.

Sandra Aparecida dos Reis, Maria do Carmo Gouveia Peluzio, Josefina Bressan
Diabetes/Metabolism Research and Reviews, v. 2018, p.1-8
Impact factor: 3,263

Abstract: The intestinal microbiota has come to be considered an additional risk factor for the development of metabolic diseases. Considering the potential role of antimicrobials as modulators of the intestinal microbiota, they have been investigated for use in the adjuvant treatment of obesity and insulin resistance. In this regard, the present manuscript aimed to review the effect of regular use of antimicrobials on the treatment of obesity and/or IR, as well as its associated mechanisms. The regular use of antimicrobials does not seem to influence the body weight and adiposity of its consumer. Regarding IR, clinical trials did not observe positive effects, on the other hand, most of the experimental studies observed an increase in insulin sensitivity. The mechanisms used by antimicrobials that could lead to the improvement of insulin sensitivity are dependent on the modulation of the intestinal microbiota. This modulation would lead to a reduction in the stimulation of the immune system, as a consequence of improved intestinal barrier and/or the reduction of gram-negative bacteria in the microbiota. In addition, the secretion of GLP-1 would be modulated by metabolites produced by the intestinal microbiota, such as secondary bile acids and short chain fatty acids. Based on the results obtained to date, more studies should be performed to elucidate the effect of these drugs on obesity and IR, as well as the mechanisms involved. In addition, the cost-benefit of the regular use of antimicrobials should be investigated, as this practice may lead to the development of antimicrobial-resistant microorganisms.

Traditional’ and ‘healthy’ dietary patterns are associated with low cardiometabolic risk in brazilian subjects

Brenda Kelly Souza Silveira , Juliana Farias de Novaes, Nínive de Almeida Reis, Larissa Pereira Lourenço, Ana Helena Moretto Capobiango, Sarah Aparecida Vieira e Helen Hermana Miranda Hermsdorff
Cardiology Research and Practice, v. 2018, p.1-11

Abstract: .is study aimed at determining the dietary patterns and investigating their association with cardiometabolic risk markers in a brazilian population at risk. . Is transversal study was carried out with data of 265 patients (n 123 M/172 W, age 42 ± 16 years) of the Cardiovascular Health Care Program—PROCARDIO-UFV, Brazil—who had their first appointment between 2012 and 2017. A 24-hour recall was applied. .e dietary patterns were determined by Principal Component Analysis. Anthropometric, clinical-metabolic, sociodemographic, and lifestyle data were collected through medical record analysis. Five patterns were identified: “Traditional”, “Caloric”, “Unhealthy”, “Healthy,” and “Healthy Snacks”. In bivariate analysis, the “Healthy” pattern was negatively associated with WC (waist circunference), BMI (body mass index), WHR (waist-to-hip ratio), SBP (systolic blood pressure), fasting glucose, TG/HDL, LDL/HDL, and TG/HDL values and positively to HDL. .e “Traditional” pattern was positively associated with adiposity indicators (WC, BMI, and WHR) and negatively associated with body fat, TyG (triglycerideglucose index), HDL, and LDL (P < 0.05). However, in adjusted models of Poisson regression, individuals with positive factor score (higher adherence) in the “Traditional” and “Healthy” patterns had less occurrence of abdominal obesity (PR 0.85; 95% CI 0.74–0.99/PR 0.88; 95% CI 0.02–0.76), as well as dyslipidemia (PR 0.06; 95% CI 0.02–0.51/PR 0.03; 95% CI 0.01–0.27), diabetes (PR 0.05; 95% CI 0.01–0.45/PR 0.02; 95% CI 0.01–021), and hypertension (PR 0.06; 95% CI 0.02–0.50/PR 0.02; 95% CI 0.01–0.21). A greater adherence to the “Healthy” pattern was associated with lower values to cardiometabolic risk markers and less occurrence of chronic diseases, while the “Traditional” pattern presented contradictory results

Using the method of triads in the validation of a food frequency questionnaire to assess the consumption of fatty acids in adults

D. C. G. da Silva, W. Segheto, M. F. C. de Lima, M. C. Pessoa, M. C. G. Peluzio, D. M. L. Marchioni, D. B. Cunha, G. Z. Longo
Journal of Human Nutrition and Dietetics, v.31, n.1, p.85-9
Impact factor: 2,638

Abstract: Background: It is of great value to develop valid instruments to estimate food consumption; for this purpose, the triads method has been applied in validation studies of dietary intake to evaluate the correlation between three measurements [food frequency questionnaire (FFQ), reference method and biomarker]. The main aim of the present study was to validate a FFQ for Brazilian adults by means of the method of triads by estimating the ingestion of total fatty acids based on the level of saturation. Methods: The present study enrolled 152 Brazilian adults of both sexes, who were residents in the city of Vicosa, Brazil. The ingestion of total saturated, monounsaturated, polyunsaturated, trans, linoleic and linolenic fatty acids was assessed by means of a FFQ, two food records, and biomarkers, which were detected by gas chromatography. The validation coefficients were calculated using the method of triads and concordance was determined by Kappa statistics. Results: The FFQ was considered an adequate dietary method, because, based on the validation coefficients, it estimates the intake of total fat (0.84), as well as linolenic (0.90) and linoleic acids (0.31). A high concordance rate was confirmed for all nutrients assessed by the FFQ and food records. Regarding the biomarkers, linolenic acid and linoleic acid presented greater concordance. Conclusions: According to the validation coefficients, the FFQ precisely estimated total fat, linolenic acid and linoleic acid contents.

Validity of the body adiposity index in predicting body fat in adults: a systematic review.

Matheus Santos Cerqueira, Carolina Araújo dos Santos, Diego Augusto Santos Silva, Paulo Roberto dos Santos Amorim, João Carlos Bouzas Marins, e Sylvia do Carmo Castro Franceschini
Advances in nutrition, v.9, p. 617-624
Impact factor: 5,233

Abstract: The Body Adiposity Index (BAI) is a practical anthropometric method used to measure body fat (BF) percentage (BF%). Recently developed, the validity and precision of BAI has been studied with adult samples of men and women, populations from different countries and ethnicities, varying amounts of BF, and sensitivity to detecting change over time. However, it is still necessary to determine its potential use in clinical practice and epidemiologic studies. Thus, our objective was to verify, through a systematic review, the validity of the BAI in predicting BF% in adults. Two independent researchers performed a search using PubMed, Web of Science, Science Direct, and Scopus databases. In order to be included, the studies had to use dual-energy X-ray absorptiometry (DXA) as a reference method. We excluded studies with samples from individuals with diseases or syndromes that alter the regional distribution of BF%. We included 19 studies with samples on individuals from different continents, varied ethnicities, both sexes, and a wide age range (18–83 y). The concordance of the BAI with DXA assessed by Lin’s concordance correlation coefficient showed results classified as poor (pc < 0.90). Bland-Altman plots showed that the BAI produced large individual errors when predicting BF% in all studies using this analysis. The studies were consistent in affirming that the BAI showed limited capacity to estimate BF% in adults. The BAI shows wide individual errors, in agreement with the reference method, and a lack of sensitivity in detecting change in BF% over time. The method presents a systematic error of BF% overestimation in individuals with ≤20% of BF, and underestimation in individuals with >30% of BF, regardless of sex, age, and ethnicity. The results of this systematic review show enough evidence that the BAI does not present satisfying results, and its use is not recommended for BF% determination in adults.

Visceral adiposity index is a better predictor of unhealthy metabolic phenotype than traditional adiposity measures: results from a population-based study

Fabrícia Geralda Ferreira1, Leidjaira Lopes Juvanhol, Danielle Cristina Guimarães da Silva e Giana Zarbato Longo
Public Health Nutrition, v.22, p 1-10
Impact factor: 2,326

Abstract: Objective: The present study aimed to investigate whether the visceral adiposity index (VAI) is an effective predictor to identify unhealthy metabolic phenotype by comparing normal-weight and overweight individuals. Design: A population-based cross-sectional study. Data were collected by interviews, anthropometric evaluation, dietetic, clinical and laboratory tests. The area under the receiver-operating characteristic curve (AUC) and prevalence ratio (PR), obtained from Poisson regression, were used to compare the predictive capacity of the obesity indicators evaluated (VAI, BMI, waist and neck circumference, waist-to-height and waist-to-hip ratios) and their association with the unhealthy metabolic phenotype. All analyses were stratified by sex and by nutritional status. Setting: Viçosa, Minas Gerais, Brazil. Participants: A total of 854 Brazilian adults (20–59 years old) of both sexes. Results: VAI was the best predictor for unhealthy metabolic phenotype among men (AUC=0·865) and women (AUC=0·843) at normal weight. VAI also had the best predictive capacity among overweight women (AUC=0·903). Among overweight men, its accuracy (AUC=0·830) was higher than that of waist-to-hip ratio. In the adjusted regression models, VAI was the indicator most strongly associated with the unhealthy metabolic phenotype, especially among those with normal weight (PR=6·74; 95 % CI 3·15, 14·42 for men; PR=7·14; 95 % CI 3·79, 13·44 for women). Conclusions: VAI has better predictive capacity in detecting unhealthy metabolic phenotype than conventional anthropometric indicators, regardless of nutritional status and sex.

Vitamin D status, oxidative stress, and inflammation in children and adolescents: a systematic review

Mariana de Santis Filgueiras, Naruna Pereira Rocha, Juliana Farias de Novaes and Josefina Bressan
Critical Reviews in Food Science and Nutrition, 2018
Impact Factor: 6,077

Abstract:Vitamin D deficiency is considered a global public health problem with high prevalence in children and adolescents. The majority of the studies in the literature have identified a relationship between vitamin D insufficiency/deficiency and obesity, as well as other traditional cardiometabolic risk factors in children and adolescents. Scarce studies address vitamin D status with oxidative stress and inflammation in the young population. The aim of this systematic review was to evaluate the evidence of the association of vitamin D status with oxidative stress and inflammation in children and adolescents. This is a systematic review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) guideline on reporting systematic reviews. Eight studies were selected for this review. All included studies evaluated inflammatory biomarkers and two out of eight evaluated biomarkers of oxidative stress. The majority of the studies (five out of eight) found association of vitamin D status with biomarkers of oxidative stress and inflammation such as C-reactive protein (CRP), interleukin-6 (IL-6), cathepsin S, vascular cell adhesion molecule-1 (VCAM-1), malondialdehyde (MDA), myeloperoxidase, 3-nitrotyrosine, and superoxide dismutase (SOD). Vitamin D status is associated with oxidative stress and inflammation in the majority of the studies with children and adolescents. Thus, the assessment of vitamin D status is important because it is associated with nontraditional cardiometabolic markers in the pediatric population

Waist circumference, waist-to-height ratio and conicity index to evaluate android fat excess in brazilian children

Mariana De Santis Filgueiras, Sarah Aparecida Vieira, Poliana Cristina de Almeida Fonseca, Patrícia Feliciano Pereira, Andréia Queiroz Ribeiro, Silvia Eloiza Priore, Sylvia do Carmo Castro Franceschini e Juliana Farias de Novaes
Public Health Nutrition, v.2018, p.1-7
Impact factor: 2,326

Abstract: Objective: To evaluate the ability of anthropometric measurements to identify excess android fat and to propose cut-off points for excess central adiposity in children, according to age and sex. Design: A cross-sectional study with children from a municipality of Minas Gerais, Brazil. Receiver-operating characteristic curve analyses were performed to evaluate waist circumference (WC), waist-to-height ratio (WHtR) and conicity index (C-index) in estimating excess android fat by dual energy X-ray absorptiometry (DXA). Setting: Viçosa, Minas Gerais, Brazil. Subjects: Children aged 4–9 years (n 788). Results: Overweight prevalence was 29·1 % and android fat percentage was higher among girls. All central fat measurements were able to discriminate excess android fat in the age groups evaluated, especially WC and WHtR, with cut-off points showing good sensitivity and specificity overall. Conclusions: Because these methods are easy to obtain and inexpensive, it is possible to use WC, WHtR and C-index in population surveys to evaluate central obesity. The proposed cut-off points showed satisfactory values of sensitivity and specificity and can be used in epidemiological studies.

Waist-to-height ratio index or the prediction of overweight in children

Sarah Aparecida Vieira, Andréia Queiroz Ribeiro, Helen Hermana Miranda Hermsdorff, Patrícia Feliciano Pereira, Silvia Eloiza Priore, Sylvia do Carmo Castro Franceschini
Revista Paulista de Pediatria, v.36, p.52-58.
Impact factor

Abstract: Objective: To identify a low-cost abdominal adiposity index that has a higher accuracy in predicting excess weight in children aged four to seven years old. Methods: A cross-sectional study with a sample of 257 children aged 4 to 7 years old. Indicators of abdominal adiposity assessed were: waist circumference (WC), waistto-height ratio (WHR) and central fat percentage (measured by dual energy X-ray absorptiometry – DEXA). Overweight children were classified using body mass index by age (BMI/age). In the analysis, the prevalence ratio (PR) using Poisson regression with a robust variance was estimated, and a receiver operating characteristic (ROC) curve was built, with a statistical significance of p<0.05. Results: The prevalence of overweight children was 24.9% and a higher median of all abdominal adiposity indicators was observed in the overweight group. Children with increased values of WC (PR=4.1; 95%CI 2.86–5.86), WHR (PR=5.76; 95%CI ​​4.14–8.02) and a central fat percentage (PR=2.48; 95%CI 1.65–3.73) had a higher prevalence of being overweight. Using the ROC curve analysis, the WHR index showed a higher area under the curve, when compared to the WC and to the central fat percentage estimated by DEXA for predicting the classification of being overweight


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