Publications of 2022

Thaisa Agrizzi Verediano, Hércia Stampini Duarte, Nikolai Kolba, Yimin Fu, Maria Cristina Dias Paes, Elad Tako
Food Research International, v.157, p. 1-12
Impact factor: 6.475

Abstract: Black corn (Zea mays L.) is a pigmented type of this cereal whose color of the kernels is attributed to the presence of the anthocyanins. In this study, we assessed the black corn soluble extract (BCSE) effects on the intestinal functionality, morphology, and microbiota composition using an in vivo model (Gallus gallus) by an intraamniotic
administration. The eggs were divided into four groups (n = 6–10): (1) No Injection; (2) 18 MΩ H2O/cm; (3) 5% (5 mg/mL) BCSE; (4) 15% (15 mg/mL) BCSE. The BCSE showed anti-inflammatory effects bydown regulating the gene expression of tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL6), and the transcriptional nuclear factor kappa beta (NF-κB). Further, the BCSE increased the relative abundance of E. coli and Clostridium. 5% and 15% BCSE increased the hepatic glycogen and upregulated the gene expression of sodiumglucose transport protein (SGLT1). In the morphology, 5% and 15% BCSE increased the goblet cell (GC) number on the crypt, the GC size on the villi, Paneth cell number on the crypt, and the acid GC. Further, the BCSE strengthened the epithelial physical barrier through upregulating the intestinal biomarkers AMP- activated protein kinase (AMPK) and caudal-related homeobox transcriptional factor 2 (CDX2). The overall result suggests that the BCSE promotes intestinal anti-inflammatory effects as well as enhances the intestinal barrier function.

Ana Paula Silva Caldas, Daniela Mayumi Usuda Prado, Ana Paula Dionísio, Helen Hermana Miranda Hermsdorff, Josefina Bressan
British Journal of Nutrition, v. 2022, p.1-11
Impact factor: 3.718

Abstract: Several mechanisms have been proposed for the beneficial effect of nuts on health. However, Brazil and cashew nuts remain the least studied. We aim to evaluate the effect of these nuts within an energy-restricted diet on body weight, body composition, cardiometabolic markers, and endothelial function in cardiometabolic risk women. Brazilian nuts study is a randomized controlled parallel 8-week dietary intervention trial. Forty women were randomly allocated to 1) Control group: Energy-restricted diet without nuts, n= 19 or, 2) Brazil and cashew nuts group (BN-Group): Energy-restricted diet containing daily 45 g of nuts (15 g of Brazil nuts + 30g of cashew nuts), n= 21. At the beginning and final intervention, anthropometry, body composition, and blood pressure were measured. Fasting blood sampling was obtained to evaluate lipid profile, glucose homeostasis, and endothelial function markers. After 8-week, plasma selenium concentration increased in BN-group (∆ = + 31.5 ± 7.8 μg/L; p= 0.001). Brazil and cashew nuts intake reduced total body fat (-1.3 ± 0.4 %) parallel to improvement of lean mass percentage in BN-group compared to the control. Besides, the soluble adhesion molecule VCAM-1 decreased (24.03 ± 15.7 pg/mL vs. -22.2 ± 10.3 pg/mL; p= 0.019) after Brazil and cashew nuts intake compared to the control. However, lipid and glucose profile markers, apolipoproteins, and blood pressure remained unchanged after the intervention. Thus, the addition of Brazil and cashew nuts to an energy-restricted diet can be a healthy strategy to improve body composition, selenium status, and endothelial inflammation in cardiometabolic risk women.

Luiza de Paula Dias Moreira, Bárbara Nery Enes, Vinícius Parzanini Brilhante de São José, Renata Celi Lopes Toledo, Luiz Carlos Maia Ladeira, Rodrigo Rezende Cardoso, Vinícius da Silva Duarte, Helen Hermana Miranda Hermsdorff, Frederico Augusto Ribeiro de Barros, Hércia Stampini Duarte Martino
Foods, v.11, p.1-18
Impact factor: 4.350

Abstract: We hypothesized that the consumption of chia (Salvia hispanica L.) flour (CF) and chia oil (CO) improves metabolic disorders in the liver of Wistar rats (Rattus norvegicus domestica) fed a high-fat and high-fructose (HFHF) diet. The animals were fed a HFHF diet (n = 30) or AIN93-M standard diet (n = 10) for eight weeks. After this period, the animals fed HFHF were divided into three groups (n = 10): HFHF diet, HFHF plus 14.7% of CF, and HFHF plus 4% of CO. Histological and biochemical analyses, gene expression, protein levels related to inflammation, and oxidative stress were evaluated in the liver. The HFHF diet caused lipogenesis, liver steatosis, oxidative stress, and inflammation in the animals. The CF and CO intake increased the liver total antioxidant capacity and superoxide dismutase, decreased nitric oxide levels and liver steatosis. Furthermore, the CF and CO led to the upregulation of Cpt1a and Adipor2, respectively, whereas CF downregulated Srebf1. CO intake decreased blood glucose, triglycerides, and the animals’ body weight. Chia did not show effects on mitigating liver pro-inflammatory status, which it may indicate occurs later. The addition of chia into an unbalanced diet is a good and relevant strategy to reduce liver metabolic disorders caused by the high consumption of fructose and saturated fat.

Francilene Maria Azevedo, Almeida Abudo Leite Machamba, Aline Carare Candido, Carina Aparecida Pinto, Sílvia Oliveira Lopes, Mariana de Souza Macedo, Sarah Aparecida Vieira Ribeiro, Silvia Eloiza Priore, Sylvia do Carmo Castro Franceschini
Biological Trace Element Research, v. 2022, p. 1-10
Impact factor: 3.738

Abstract: Iodine is a micronutrient essential for maintaining normal body functioning, and the consumption depends on the distribution in the environment, and insufficient or excessive intake results in thyroid dysfunction. The purpose of this review was to evaluate the correlation between iodine concentration in drinking water and the iodine status of the population. The systematic review was conducted following the PRISMA guidelines and was registered at the International Prospective Register of Ongoing Systematic Reviews (CRD42019128308). A literature search was conducted using MEDLINE/PUBMED (National Library of Medicine), LILACS (Latin-American and Caribbean Literature on Health Sciences), and Cochrane Library, June 2021. The quality of the studies was assessed by a checklist for cross-sectional studies developed by Joanna Briggs Institute. The initial search identified 121 articles, out of which ten were included in this systematic review, and five were included in the meta-analysis. Among the articles listed, six adopted cutoff points to classify the iodine content in the drinking water. The study identified median iodine concentration in drinking water from 2.2 to 617.8 μg/L and the correlation between iodine concentration in drinking water and urinary iodine concentration was 0.92, according to meta-analysis. Furthermore, the iodine status was correlated to the iodine content in water. The determination of a cutoff point can contribute to the implementation of iodine consumption control measures.

Effects of dietary fiber on intestinal iron absorption, and physiological status: a systematic review of and clinical studies

Thaisa Agrizzi Verediano, Nikita Agarwal, Mariana Juste Contin Gomes, Hércia Stampini Duarte Martino, Elad Tako
Critical Reviews in Food Science and Nutrition, v. 2020. P. 1-16
Impact factor: 11.176

Abstract: The benefits of dietary fiber on intestinal health have been well established. However, there is no consensus on the dietary fiber effects on mineral absorption. The objective of this systematic review is to discuss the evidence on the dietary fiber effects on iron absorption and iron status-related biomarkers. A comprehensive search of 3 databases: PubMed, Scopus and Web of Science was carried out. We followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, and a total of 32 studies were included with 9 of them clinical studies and 23 in vivo. The studies included assessment of dietary fiber in the form of fructo-oligosaccharides, galacto-oligosaccharides, inulin, pectin, guar gum, oligofructose, xylo-oligosaccharides, and mannan-oligosaccharide. Hemoglobin (n = 21) and fractional iron absorption (n = 6) were the most frequently reported outcomes. The results showed no significant correlations between consumption of dietary fiber to iron absorption/status-related biomarkers. However, the current evidence may not be substantial to invalidate the recommendation of dietary fiber as an agent to improve dietary iron bioavailability, and absorption. In conclusion, there is a need to conduct further clinical trials with long dietary fiber intervention focusing on population at high risk for iron deficiency.

Emily Ferreira, Kíllya Paiva Santos, Glauce Dias da Costa, Tiago Ricardo Moreira, Luíza Delazari Borges, Heloísa Helena Dias, Daniel Souza Santos, Ítalo Augusto Cunha Rodrigues, Mariângela Orlandi Barbiero, Rosângela Minardi Mitre Cotta
Social innovations Journal, v. 12. P. 1-12

Abstract: Background: This systematic review and meta-analysis aims to estimate the evidence of the effectiveness of the active teaching and learning methods in health majors. Methods: We systematically searched four major databases (i.e., PubMed/MEDLINE, LILACS, Scielo and ERIC). This review was according to the PRISMA method and registration in PROSPERO (CRD42018094054). This review included studies to compare active teaching and learning methods to the traditional methods in the different health majors. We consider all original articles published in the databases until April 29th, 2020. Data were analyzed using R software. The pooled estimates with 95% confidence intervals (CIs) were presented using a forest plot. Higgins and Egger’s tests were used to assess heterogeneity and publication bias, respectively. Primary estimates were pooled using a random-effects meta-analysis model. Results: Of the total of 27 identified articles 16 studies met the inclusion criteria and were included in this meta-analysis. The included studies sample size ranged from 18 to 379. The total sample was 4031 undergraduates from four health courses. The combined meta-analysis was 67% (95% CI: 0.13-0.54). Conclusions: Our finding suggested that evidence exists of the effectiveness of the active teaching and learning methods when compared to the traditional methods in the health courses.

Bruna Clemente Cota, Felício Roberto Costa, Leidjaira Lopes Juvanhol, Sarah Aparecida Vieira Ribeiro, Silvia Eloiza Priore, Eliane Rodrigues de Faria, Franciane Rocha de Faria, Patrícia Feliciano Pereira
British Journal of Nutrition, v. 2022
Impact factor: 3.718

Abstrct: A new phenotype of obesity has been studied: normal-weight obesity (NWO), which describes individuals with normal-weight by body mass index (BMI) and excess body fat. Despite normal-weight, individuals with NWO have a higher cardiometabolic risk. There is still a gap in the literature on the subject, especially in adolescents, as studies with this population are scarce. Therefore, this study aims to investigate the sociodemographic factors, family history of chronic non-communicable diseases, body perception, lifestyle and food consumption associated with NWO in adolescents. This is a cross-sectional study, conducted with 506 normal-weight adolescents aged 10 to 19 years, of both sexes. Weight and height were obtained and BMI/age was calculated. Body fat analysis was performed using dual-energy X-ray absorptiometry. Sociodemographic data, level of physical activity, food consumption, body self-perception and lifestyle habits were also obtained. Logistic regression with hierarchical approach was used to analyze the associations. The odds of NWO are greater with age (OR=1.14; 95% CI=1.04-1.26), lower in male adolescents (OR=0.21; 95% CI=0.11-0.41) and higher in those with a history of familial dyslipidemia (OR=1.81; 95% CI=1.01-3.28). Adolescents satisfied with their body (OR=0.30; 95%CI 0.16-0.56) and physically active (OR=0.44; 95% CI=0.24-0.81) have a lower odds of NWO, compared to the others. In addition, it was observed that the odds of NWO is greater among adolescents who use sweeteners (sugar substitutes) (OR=3.84; 95% CI=1.70-8.65). The factors associated with NWO were female sex, older age, positive family

Jerusa da Mota Santana, Marcos Pereira, Gisele Queiroz Carvalho, Maria do Carmo Gouveia Peluzio, Iúri Drumond Louro, Djanilson Barbosa Dos Santos, Ana Marlucia Oliveira
Nutrients, v.14, p. 1 -13
Impact factor: 5.717

Abstract: The polymorphisms of fatty acid desaturase genes FADS1 and FADS2 have been associated with an increase in weight gain. We investigated FADS1 and FADS2 gene polymorphisms and the relation between ω-3 and ω-6 fatty acid plasma concentrations and gestational weight gain. A prospective cohort study of 199 pregnant women was followed in Santo Antônio de Jesus, Brazil. Plasma levels of polyunsaturated fatty acids (PUFAs) were measured at baseline and gestational weight gain during the first, second, and third trimesters. Fatty acid recognition was carried out with the aid of gas chromatography. Single nucleotide polymorphisms (SNPs) were genotyped using real-time PCR. Statistical analyses included Structural Equation Modelling. A direct effect of FADS1 and FADS2 gene polymorphisms on gestational weight was observed; however, only the SNP rs174575 (FADS2) showed a significant positive direct effect on weight over the course of the pregnancy (0.106; p = 0.016). In terms of the influence of SNPs on plasma levels of PUFAs, it was found that SNP rs174561 (FADS1) and SNP rs174575 (FADS2) showed direct adverse effects on plasma concentrations of ω-3 (eicosapentaenoic acid and alpha-linoleic acid), and only SNP rs174575 had positive direct effects on plasma levels of ARA and the ARA/LA (arachidonic acid/linoleic acid) ratio, ω-6 products, while the SNP rs3834458 (FADS2) had an adverse effect on plasma concentrations of EPA, leading to its increase. Pregnant women who were heterozygous and homozygous for the minor allele of the SNP rs3834458 (FADS2), on the other hand, showed larger concentrations of series ω-3 substrates, which indicates a protective factor for women’s health.

Andressa Ladeira Bernardes, Luís Fernando de Sousa Moraes, Bruna Cristina dos Santos Cruz, Lisiane Lopes da Conceição, Leandro Licursi de Oliveira, Mariaurea Matias Sarandy, Reggiani Vilela Gonçalves, Maria do Carmo Gouveia Peluzio
British Journal of Nutrition, v. 2022, p.1-12
Impact factor: 3.718

Abstract: The development of colorectal cancer involves some morphological changes, and in the initial stage, pre-neoplastic lesions called aberrant crypt foci (ACF) appear. Thus, an intervention with sources of bioactive compounds such as Hibiscus sabdariffa L., rich in phenolic compounds and anthocyanins, could attenuate the risk of developing these lesions due to its antioxidant, anti-inflammatory and anti-proliferative properties. Therefore, the aim of this study was to evaluate the effects of 5 % and 10 % supplementation of dehydrated H. sabdariffa calyces (DHSC) during the development of 1,2-dimethylhydrazine-induced pre-neoplastic lesions in male BALB/c mice. The characterisation of DHSC was carried out. The in vivo experiment lasted 12 weeks, and the animals were randomly divided into three experimental groups: the control group (CON) and the supplemented groups with 5 % DHSC and 10 % DHSC. The activities of liver enzymes catalase (CAT) and superoxide dismutase were determined. In addition, ACF, SCFA, presence of inflammatory infiltrates, goblet cells and leucocytes in the colonic mucosa were quantified. There was a significant reduction in ACF and the presence of inflammatory infiltrates in the colon of animals in groups 5DHSC and 10DHSC. In addition, the 10DHSC group showed an increase in the activity of the CAT enzyme, in the production of butyrate and in the presence of natural killer cells in the colon, in addition to more hypertrophied goblet cells. Based on these findings, it is suggested that DHSC supplementation may be recommended to attenuate cellular responses in the early stage of pre-neoplastic lesions.

Marina Martins Daniel, Juliana Costa Liboredo, Lucilene Rezende Anastácio, Tamires Cássia de Melo Souza, Lívya Alves Oliveira, Ceres Mattos Della Lucia, Lívia Garcia Ferreira
Frontiers in Nutrition, v.2022, p.1-11
Impact factor: 6.576

Abstract: Introduction and aims: The behavioral changes that arose from quarantine due to the COVID-19 pandemic may have impacted the weight of people. This study aims to investigate the incidence and predictors of weight gain during the quarantine period. Methods: An online survey was performed five months after the social distance measures implementation. Participants recorded their current and usual weight before lockdown. A multivariate logistic regression model was performed. Results: Data on 1334 participants were evaluated (33.6y, 79.8% females), and 58.8% have gained weight (3.0 kg; 0.1 to 30.0 kg). Predictors of weight gain were increased food intake (OR = 5.40); snacking (OR = 2.86); fast food (OR = 1.11); canned products (OR = 1.08); and in physical activity (OR = 0.99) concerning the period before the pandemic; also time spent at work, including household chores (OR = 1.58); evening snack (OR = 1.54); higher frequency of alcoholic beverage intake (OR = 1.59) and dose of alcoholic beverage (OR = 1.11); uncontrolled eating (OR = 1.01), and vegetable intake (OR = 0.92) during the quarantine and physical activity before pandemic period (OR = 0.99). Conclusion: Most participants have gained weight during the pandemic because of working changes, lifestyle, eating habits changes, and uncontrolled eating behavior. These results can be useful to encourage changes during future quarantine periods to prevent weight gain.

Leidjaira Lopes Juvanhol, Aline Silva‑Costa, Lucia Rotenberg, Arlinda B. Moreno, Enirtes Caetano Prates Melo, Itamar S. Santos, Maria Angélica Antunes Nunes, Susanna Toivanen, Dóra Chor, Rosane Härter Griep
Journal of Eating Disordes, v. 2022, p. 1.9
Impact factor: 4.049

Abstract: Background: Job strain has been reported as a trigger for binge eating, yet the underlying mechanisms have been unclear. The aim of this study was to evaluate whether work-family conflict is a pathway in the association between job strain and binge eating, considering the possible effect-modifying influence of body mass index (BMI). Methods: This cross-sectional analysis included 12,084 active civil servants from the multicenter Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Job strain was assessed using the Demand-Control-Support Questionnaire. Work-family conflict was considered as a latent variable comprising three items. Binge eating was defined as eating a large amount of food in less than 2 h at least twice a week in the last six months with a sense of lack of control over what and how much was eaten. Structural equation modelling was used to test the role of work-family conflict in the association between job strain and binge eating, stratifying for BMI. Results: For individuals of normal weight, positive associations were found between skill discretion and binge eating (standardized coefficient [SC] = 0.209, 95%CI = 0.022-0.396), and between psychological job demands and work-family conflict (SC = 0.571, 95%CI = 0.520-0.622), but no statistically significant indirect effect was found. In overweight individuals, psychological job demands, skill discretion, and work-family conflict were positively associated with binge eating (SC = 0.099, 95%CI = 0.005-0.193; SC = 0.175, 95%CI = 0.062-0.288; and SC = 0.141, 95%CI = 0.077-0.206, respectively). Also, work-family conflict was observed to be a pathway on the associations of psychological job demands and decision authority with binge eating (SC = 0.084, 95%CI = 0.045-0.122; and SC = – 0.008, 95%CI = – 0.015- – 0.001, respectively). Conclusions: Work-family conflict partly explains effects of high levels of psychological job demands and low levels of decision authority on binge eating among overweight individuals. Moreover, skill discretion is positively associated with binge eating, regardless of BMI category.

Retail food outlets and metabolic syndrome: a systematic review of longitudinal studies.

Fernanda Martins de Albuquerque, Milene Cristine Pessoa, Mariana De Santis Filgueiras, Danielle Soares Gardone,
Juliana Farias de Novaes
Nutrition Reviews, v.2022
Impact factor: 7.11

Abstract: Context: The community food environment covers the type, quantity, density, location, and access to retail food outlets, and its influence on eating behavior, obesity, and metabolic syndrome has been investigated. Objective: To evaluate the evidence on longitudinal associations between objectively measured retail food outlets and metabolic syndrome components in children, adolescents, and adults. Data extraction: This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Study quality and risk of bias were assessed with the Newcastle-Ottawa Scale. Data sources: The Scopus, Embase, Web of Science, Scielo, PubMed, MEDLINE, and Lilacs databases were searched without any restriction on publication dates. Data analysis: Of the 18 longitudinal studies included, significant associations were reported in 9 between retail food outlets and metabolic syndrome components in adults (6 positive associations, 2 negative, and 1 both positive and negative), and in 3 studies of children and adolescents (2 negative associations and 1 both positive and negative). Six studies with adults found no association. Conclusion: Limited evidence was found for longitudinal associations between retail food outlets and metabolic syndrome components. In future studies, researchers should consider the use of standardized retail food outlet measurements and accurate analysis to better understand the influence of the community food environment on metabolic syndrome.

Daniel Barbosa Alcântara, Ana Paula Dionísio, Adriana G. Artur, Brenda Kelly Souza Silveira, Amanda F. Lopes, Jhonyson A. C. Guedes, Lícia R. Luz, Ronaldo F. Nascimento, Gisele S. Lopes, Helen Hermana Miranda Hermsdorff, Guilherme J. Zocolo
Food Chemistry, v. 137, p.1-17
Impact factor: 7.514

Abstract: Se is an essential element in mammals. We review how its bioavailability in soil and the ability of plants to accumulate Se in foods depends on the soil Se profile (including levels and formats), besides to describe how the various selenoproteins have important biochemical functions in the body and directly impact human health. Owing to its favorable characteristics, the scientific community has investigated selenomethionine in most nut matrices. Among nuts, Brazil nuts have been highlighted as one of the richest sources of bioavailable Se. We summarize the most commonly used analytical methods for Se species and total Se determination in nuts. We also discuss the chemical forms of Se metabolized by mammals, human biochemistry and health outcomes from daily dietary intake of Se from Brazil nuts. These findings may facilitate the understanding of the importance of adequate dietary Se intake and enable researchers to define methods to determine Se species.

Flavia Glavão Cândido, Raquel Duarte Moreira Alves, Dayse Mara de Oliveira Freitas, Jersica Martins Bittencourt, Daniela Mayumi Usuda Prado Rocha, Rita de Cassia Gonçalves Alfenas
Clinical Nutrition ESPEN, v. 2022, p.1-6
Impact factor: 7.324

Abstract: Objective. To investigate if the gout-protective effect of low-fat dairy products could be attributed to the urate-lowering effect of calcium. Methods. This is a placebo-controlled trial in which thirty-five adult (aged 18–42 years) female low-calcium consumers (<800 mg/d) were randomized to one of three treatment groups: low calcium breakfast (control, ∼70 mg of calcium/d) –C or high-calcium breakfast (∼770 mg/d) from calcium citrate – CIT or from skim milk – SM, during 45 consecutive days. Breakfasts were matched for potential confounders and were provided as part of an energy-restricted normoprotein diet containing an additional 800 mg of calcium/d. Dual-energy X-ray absorptiometry measurements (body fat assessment) and fasting blood samples (urate, ionic calcium, PTH, and 1,25-(OH)2-D3) were taken at baseline and the end of the experiment. Clinical trial registration: http://www.ensaiosclinicos.gov.br/ (RBR-7Q2N33). Results. Despite no significant changes in total body weight/fat, CIT and SM led to a significant reduction in serum urate and ionic calcium, but did not affect PTH and vitamin D concentrations compared to C. CIT and SM reduced baseline serum urate by ∼14% and ∼17%, respectively. There was a trend to a positive correlation between changes in serum urate and changes in ionic calcium on day 45 (r = 0.327, P = 0.055). Conclusions. Calcium supplementation (770 mg/d from dairy or calcium citrate) reduced serum urate concentrations, suggesting that the gout-protective effect of low-fat dairy consumption is at least partly due to a urate-lowering effect of calcium.

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